NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group). Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:Zerit
Code name:BMY-27857
Chemical structure:
  • 1-(2,3-dideoxy-beta-glycero-pent-2-enofuranosyl)thymine
  • 2',3'-didehydro-3'-deoxythymidine
  • 3'-deoxy-2'-thymidinene