Title: Changes in Mood. Subtitle: Mood changes can be feelings of distress, sadness or symptoms of depression, and anxiety. 1. Distress: An unpleasant psychological, social, spiritual, and/or physical experience that affects the way you think, feel, or act. 2. Anxiety: A persistent feeling of distress, worry, and/or tension that can happen with or without a cause. 3. Sadness: Can cause ups and downs, feeling blue or disappointment that interferes with daily activities.