Archive - RAS Dialogue
- The Mutational Spectra of Cancer Genes in TCGA Data
The Cancer Genome Atlas has catalogued mutations in more than 30 cancer types. The NCI RAS Initiative uses TCGA data to prioritize and inform its research objectives. The bar graphs show data for KRAS, HRAS, NRAS, BRAF, TP53, EGFR, PIK3CA, and PTEN.
- A Panel of Isogenic RAS-Dependent Cell Lines Developed at the Frederick National Laboratory
Mouse embryonic fibroblasts have been engineered to lack all RAS genes on demand. Then individual RAS genes can be introduced. Such cells allow effects of drugs to be tested with more precision.
- Kras and Cancer Metabolism: A Conversation with Carla Martins
Our cells ordinarily have two copies of each gene, one maternal and one paternal. Cancers in which both KRAS genes are mutated are more aggressive and have different metabolic pathways compared to cancers which have only one mutated KRAS gene.