Archive - RAS Dialogue
- Kras and Cancer Metabolism: A Conversation with Carla Martins
Our cells ordinarily have two copies of each gene, one maternal and one paternal. Cancers in which both KRAS genes are mutated are more aggressive and have different metabolic pathways compared to cancers which have only one mutated KRAS gene.
- Targeting the KRAS G12D Neoantigen to Treat Cancer
The G12D mutation of the oncogene KRAS causes thousands of cancers every year. Steven Rosenberg and colleagues at the National Cancer Institute have treated a patient with metastatic colon cancer by using the patient's own cells to target KRAS G12D.
- Cancer Metabolism: A Conversation with Jason Locasale
Cancers driven by oncogenes such as RAS have metabolic pathways that are significantly altered compared to normal cells. Jason Locasale studies how such differences can be used as vulnerabilities for improved treatments.