2015 - RAS Dialogue
- Targeting RAL-GEF signaling and cytokines in KRAS driven lung cancer
David Barbie's laboratory seeks to understand how cytokine production stimulated by mutant KRAS influences cancer growth. Inhibitors could improve treatments of cancers driven by mutant KRAS.
- Taking Food Away: Targeting Nutrient Scavenging by RAS-driven Cancers
Cancers driven by mutant KRAS genes are more dependent on scavenging nutrients from the tumor microenvironment, via macropinocytosis, and from internal recycling of cellular components, via autophagy. These differences may be cancer vulnerabilities.
- Targeted Therapies, Tooth Extraction, and Metastasis
Resistance often develops to targeted cancer drugs. Mouse studies indicate that dying cancer cells secrete signals that help other cancer cells survive.