2016 - RAS Dialogue
- Nutritional Requirements of Pancreatic Cancers - A Conversation with Dafna Bar-Sagi
Solid tumors in humans develop primarily from epithelial cells, which have different functions in different tissues. Pancreatic cancers derive much of their nutrition from proteins consumed from their environment.
- Faint Light at the End of the Tunnel
Many cancers are dependent on an overactive MAPK pathway. While progress in inhibiting mutant RAS proteins is still in its early phase, third-generation drugs that inhibit the next protein in the pathway, RAF, are being tested. Gideon Bollag of Plexxikon describes some of the challenges of developing inhibitors of RAF.
- Mutation-Specific Approaches to KRAS Cancers: What We Can Learn from G12C-Directed Inhibitors
Dr. Sharon Campbell discusses recent advances in targeting specific mutant forms of KRAS proteins in cancers.