RAS Dialogue
Join the discussion! Post comments, ask questions, and share information with RAS experts. Subscribe to receive notifications when a new RAS Dialogue article is posted.
-
Pancreatic Organoids - A Conversation with Senthil MuthuswamyPancreatic cancer organoids can be established from tumor biopsies more quickly and cheaply and with more success than patient-derived xenografts. The organoids mimic patient histopathology and may allow drugs to be optimized for precision medicine.
-
Tumor Microenvironment Influences Metabolism of Cancer CellsSolid tumors have disregulated blood, oxygen, and nutrient supplies that influence metabolism in different parts of the tumors. Attacking these differences will require an intimate knowledge of how cancer cells detect and adapt to their environment.
-
A Conversation with Arul ChinnaiyanArul Chinnaiyan and colleagues discovered a strong interaction between the KRAS and AGO2 proteins that seems to inhibit KRAS signaling. They are also pioneers in using genomic data to guide therapy for cancer patients.
-
Nutritional Requirements of Pancreatic Cancers - A Conversation with Dafna Bar-SagiSolid tumors in humans develop primarily from epithelial cells, which have different functions in different tissues. Pancreatic cancers derive much of their nutrition from proteins consumed from their environment.
-
A Conversation with Elizabeth JaffeeImmunotherapy uses the patient's own immune system to fight cancer, but some tumors lack significant numbers of immune cells. Elizabeth Jaffee has invented new therapies that are designed to attract immune cells to penetrate tumors.