2014 - RAS Dialogue Blog
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Quantitative Assays for RAS Pathway Proteins and Phosphorylation States
The NCI CPTAC program is applying its expertise in quantitative proteomics to develop assays for RAS pathway proteins. Targets include key phosphopeptides that should increase our understanding of how the RAS pathway is regulated.
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What Do We Mean By "RAS Pathway"?
Frank McCormick, scientific lead of the RAS Initiative, requests input from the RAS community to update our conception of the "RAS pathway".
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The RAS Initiative - Welcome
Former NCI Director and Nobel Laureate Harold Varmus describes the origins, goals, structure, and oversight of the RAS Initiative.
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A Message from Dr. Frank McCormick
Frank McCormick, pioneering RAS researcher and former head of the UCSF cancer center, describes the problem with RAS cancers and how the NCI RAS Initiative will attack them.
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Are All RAS Proteins Created Equal in Cancer?
Different cancers seem to be preferentially driven by differnt mutations in RAS genes. Channing Der discusses what mechanisms could explain these variations.