Innovative Research in Cancer Nanotechnology (IRCNs)
The IRCNs engage in directed, product-focused research that aims to translate cutting-edge science and technology into the next generation of diagnostic and therapeutic tools. These platforms serve as the core technologies for a wide array of specific applications that will ultimately benefit cancer patients.
IRCNs are designed to enable multi-disciplinary team research and transformative discoveries in basic and pre-clinical cancer research. The proposed individual, circumscribed research projects are expected to address major barriers and fundamental questions in cancer biology, diagnosis, prevention and treatment of the disease using innovative nanotechnology solutions. To advance such new nanotechnology discoveries, the platform projects take advantage of the collaborative environment of the Alliance network.
Case Western Reserve University —Treatment of Glioblastoma Using Chain-Like Nanoparticles
Synergistic activity of of iron oxide nanospheres and a drug-loaded liposomes targeted to GBM vasculature and glioma stem cells will facilitate effective treatment and ultimately eradication of the disease using a safe dose of the drugs.
Emory University — Stroma Breaking Theranostic Nanoparticles for Targeted Pancreatic Cancer Therapy
This project develops a dual-targeted and stroma breaking theranostic nanoparticle platform to address an unmet, clinical challenge of poor drug delivery efficiency in the application of nanomedicine to cancer therapy.
Massachusetts General Hospital and Harvard Univeristy — Imaging of Nanotherapeutic Drug Action
In vivo imaging analyses of therapeutic nanoparticles (TNP), addressing key questions on nanoparticle distribution (pharmacokinetics, PK) and cellular response (pharmacodynamics, PD).
Masimo Corporation — Mechanical Drugs: Harnessing Cancer Aggressiveness to Overcome Its Resistance
Developing a new therapeutic approach to triple negative breast cancer (TNBC) which is based on intracellular mechanical impact generated by plasmonic nanobubbles.
The University of Texas MD Anderson Cancer Center—Targeted Therapeutics for Ovarian Cancer and its Microenvironment – Treatment and Theoretical Modeling
Will offer nanotherapeutic formulations and novel approaches targeting multiple components of the tumor and its microenvironment, specifically for high-grade serous ovarian cancers.
Ohio State University and University of Kentucky — Optimizing RNA Nanoparticle's Size and Shape for Enhancing Cancer Targeting and Treatment
A systematic characterization of RNA nanoparticle behavior, in vitro and in vivo, to optimize its cellular delivery to triple negative breast cancer (TNBC).
University of California, Davis — The Rodent Eye as a Non-Invasive Window for Understanding Cancer Nanotherapeutics
This project uses the mouse eye as a non-surgical window for highly efficient, optical investigation of all aspects of syngeneic or xenograft models, using a state-of-the-art ocular imaging facility, the "EyePod."
University of California, Los Angeles — Mesoporous Silica Nanoparticle Platform for Treatment of Pancreas Cancer
Utilizing rationally designed mesoporous silica nanoparticles (MSNP) to provide efficacious, safe and life-prolonging chemotherapy to pancreatic cancer patients.
University of California, Los Angeles & Cedars-Sinai Medical Center — Thermoresponsive NanoVelcro CTC Purification System for Prostate Cancer Profiling
Thermoresponsive (TR)-NanoVelcro circulating tumor cell (CTC) purification system for use in the liquid biopsy of patient response to therapeutics and cancer progression.
University of Chicago — Nanoscale Metal-organic Frameworks for Light Triggered and X-ray Induced Photodynamic Therapy of Head and Neck Cancers
Addressing an unmet need in developing highly efficient and safe nanoparticles that can have much broader clinical applications for cancer by Near-IR triggered PDT and X-ray induced PDT (X-PDT) as well radioimmunotherapy.
University of North Carolina, Chapel Hill —Targeted Core Shell Nanogels for Triple Negative Breast Cancer
Improves systemic therapies of cancer using soft nanomaterials that can penetrate deep into tumors and deliver potent anticancer agents to targeted cancer cells.