Uterine Sarcoma Treatment by Stage

Treatment of stage I leiomyosarcoma of the uterus, stage I endometrial stromal sarcoma, and stage I adenosarcoma of the uterus may include:

• Surgery (total abdominal hysterectomy, bilateral salpingo-oophorectomy, and lymphadenectomy).
• Surgery followed by radiation therapy to the pelvis.
• Surgery followed by chemotherapy.

Treatment of stage II leiomyosarcoma of the uterus, stage II endometrial stromal sarcoma, and stage II adenosarcoma of the uterus may include:

• Surgery (total abdominal hysterectomy, bilateral salpingo-oophorectomy, and lymphadenectomy).
• Surgery followed by radiation therapy to the pelvis.
• Surgery followed by chemotherapy.

Treatment of stage III leiomyosarcoma of the uterus, stage III endometrial stromal sarcoma, and stage III adenosarcoma of the uterus may include:

• Surgery (total abdominal hysterectomy, bilateral salpingo-oophorectomy, lymphadenectomy, and removal of all other tissue where tumor is found).
• A clinical trial of surgery followed by radiation therapy to the pelvis.
• A clinical trial of surgery followed by chemotherapy.

There is no standard treatment for patients with stage IV leiomyosarcoma of the uterus, stage IV endometrial stromal sarcoma, or stage IV adenosarcoma of the uterus. Treatment may include a clinical trial using chemotherapy.

There is no standard treatment for recurrent uterine sarcoma. Treatment may include a clinical trial using chemotherapy.

For patients with recurrent carcinosarcoma (a certain type of tumor), treatment may include:

• Radiation therapy as palliative therapy to relieve symptoms (such as pain, nausea, or bowel problems) and improve the quality of life.
• Hormone therapy.
• A clinical trial of a new treatment.