susceptibility gene mutation
(suh-SEP-tih-BIH-lih-tee jeen myoo-TAY-shun)
- A genetic alteration that increases an individual’s susceptibility or predisposition to a certain disease or disorder. When such a variant (or mutation) is inherited, development of symptoms is more likely, but not certain. Also called deleterious mutation, disease-causing mutation, pathogenic variant, and predisposing mutation.