- Surgery to remove the entire prostate and some of the tissue around it, including the seminal vesicles (a gland that helps make semen). Nearby lymph nodes may also be removed. A radical prostatectomy may be done through an incision (cut) made in the wall of the lower abdomen or in the perineum (the area between the scrotum and anus). It may also be done using a laparoscope (a thin, tube-like instrument with a light and lens for viewing) or a special robotic system. An attempt is made to protect the nerves that control penile erection and the bladder from damage.