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liposomal cytarabine
A liposomal intrathecal formulation of the antimetabolite cytarabine. As an S-phase-specific antimetabolite, cytarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; the incorporation of cytarabine triphosphate into DNA appears to inhibit DNA polymerase and so DNA synthesis, resulting in cell death. Check for
active clinical trials
or
closed clinical trials
using this agent. (
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Synonyms:
cytarabine liposome
DepoFoam-encapsulated cytarabine
US brand name:
DepoCyt
Foreign brand name:
DepoCyte
Code name:
DTC 101
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