National Cancer Institute National Cancer Institute
U.S. National Institutes of Health National Cancer Institute
NCI Home Cancer Topics Clinical Trials Cancer Statistics Research & Funding News About NCI
NCI Drug Dictionary
Page Options
Print This Page  Print This Page
More NCI Dictionaries
Dictionary of Cancer Terms

Glossary of Statistical Terms

NCI Dictionary of Genetics Terms

Terminology Resources
Quit Smoking Today
Search for
Contains
# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All

genistein 
A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:CI 75610
Genestein
genisteol
genisterin
prunetol
sophoricol
Chemical structure names:
  • 4',5,7-trihydroxyisoflavone
  • 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one


A Service of the National Cancer Institute
Department of Health and Human Services National Institutes of Health USA.gov