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total androgen blockade (TOH-tul AN-droh-jen blah-KAYD)
Treatment used to block androgen (male hormone) activity in the body. This may be done by giving an antiandrogen drug and removing the testicles (orchiectomy) or by giving an antiandrogen drug with a gonadotropin-releasing hormone (GnRH) agonist. Total androgen blockade may stop the growth of cancer cells that need androgens to grow, and is used in the treatment of prostate cancer. Also called combined androgen blockade and complete androgen blockade.