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NCI Dictionary of Cancer Terms

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NCI Dictionary of Cancer Terms



vascular endothelial growth factor-antisense oligonucleotide  listen  (VAS-kyoo-ler EN-doh-THEE-lee-ul grothe FAK-ter-AN-tee-sents AH-lih-goh-NOO-klee-oh-tide)

  A substance that has been studied in the treatment of cancer. It binds to the RNA for a protein called vascular endothelial growth factor (VEGF) that stimulates the growth of new blood vessels. Vascular endothelial growth factor-antisense oligonucleotide blocks the cell’s ability to make VEGF, which may kill tumors that need new blood vessels to grow. It is a type of antisense oligonucleotide and a type of gene expression inhibitor. Also called VEGF-AS.