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NCI Dictionary of Cancer Terms


anti-EpCAM-Pseudomonas-exotoxin fusion protein  listen  (AN-tee ... SOO-doh-MOH-nus-EK-soh-TOK-sin FYOO-zhun PROH-teen)

  A substance being studied in the treatment of certain types of head and neck cancer. Anti-EpCAM-Pseudomonas-exotoxin fusion protein is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells. It binds to EpCAM (a protein on the surface of epithelial cells and some types of cancer cells). Also called Proxinium and VB4-845.