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NCI Dictionary of Cancer Terms


ET-743   

  A substance that comes from a type of sea squirt and is being studied in the treatment of cancer. It binds to DNA and causes breaks in the DNA. It also blocks the ability of the cell to repair the DNA damage, and may cause cancer cells to die. ET-743 is also made in the laboratory. It is a type of DNA excision repair inhibitor. Also called ecteinascidin 743 and trabectedin.