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NCI Dictionary of Cancer Terms


CIN 3  listen 

  Severely abnormal cells are found on the surface of the cervix. CIN 3 is usually caused by certain types of human papillomavirus (HPV) and is found when a cervical biopsy is done. If not treated, these abnormal cells may become cancer and spread to nearby normal tissue. Treatment for CIN 3 may include cryotherapy, laser therapy, loop electrosurgical procedure (LEEP), or cone biopsy to remove or destroy the abnormal tissue. CIN 3 is sometimes called high-grade or severe dysplasia. Also called cervical squamous intraepithelial neoplasia 3 and stage 0 cervical carcinoma in situ.