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NCI Dictionary of Cancer Terms


GDC-0449   

  A drug used to treat advanced basal cell carcinoma that has spread to other parts of the body or has come back after surgery. It is also used in patients who cannot be treated with surgery or radiation therapy. It is also being studied in the treatment of other types of cancer. GDC-0449 blocks a type of protein involved in tissue growth and repair and may block the growth of cancer cells. It is a type of Hedgehog signaling pathway antagonist. Also called Erivedge and vismodegib.

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