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NCI Dictionary of Cancer Terms

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NCI Dictionary of Cancer Terms



stem cell factor receptor  listen  (… sel FAK-ter reh-SEP-ter)

  A protein found on the surface of many different types of cells. It binds to a substance called stem cell factor (SCF), which causes certain types of blood cells to grow. Stem cell factor receptor may also be found in higher than normal amounts, or in a changed form, on some types of cancer cells, including gastrointestinal stromal tumors and melanoma. Measuring the amount of stem cell factor receptor in tumor tissue may help diagnose cancer and plan treatment. Stem cell factor receptor is a type of receptor tyrosine kinase and a type of tumor marker. Also called c-kit and CD117.