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NCI Dictionary of Cancer Terms

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IMC-1121B   

  A substance being studied in the treatment of several types of cancer, including stomach, esophageal, breast, urinary tract, and non-small cell lung cancer. IMC-1121B binds to receptors for a protein called vascular endothelial growth factor (VEGF), which may be found on some types of cancer cells. This may prevent the growth of new blood vessels that tumors need to grow. IMC-1121B is a type of antiangiogenesis agent and a type of monoclonal antibody. Also called anti-VEGFR-2 fully human monoclonal antibody IMC-1121B and ramucirumab.