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A vaccine used to prevent cervical cancer caused by human papillomaviruses (HPV) types 16 and 18. It is also used to prevent lesions that are caused by these viruses and that can lead to cervical, vulvar, or vaginal cancer. GSK-580299 is used in females aged 10-25 years. It is also being studied in the treatment of other medical conditions. It is a type of bivalent vaccine. Also called Cervarix, HPV 16/18 L1 VLP/AS04 VAC, human papillomavirus 16/18 L1 virus-like particle/AS04 vaccine, and recombinant human papillomavirus bivalent vaccine.