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NCI Dictionary of Cancer Terms


Costello syndrome  listen  (KOS-teh-loh SIN-drome)

  A rare, genetic disorder marked by developmental problems, being shorter than normal, mental retardation, heart problems, unusual facial features, and extra folds of skin around the neck, hands, and feet. People with Costello syndrome have an increased risk of certain types of cancer, such as rhabdomyosarcoma (a soft tissue tumor) and neuroblastoma (cancer of immature nerve cells).