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NCI Dictionary of Cancer Terms

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NCI Dictionary of Cancer Terms



multiple endocrine neoplasia type 2B syndrome  listen  (MUL-tih-pul EN-doh-krin NEE-oh-PLAY-zhuh ... SIN-drome)

  A rare, genetic disorder that affects the endocrine glands and causes a type of thyroid cancer called medullary thyroid cancer, pheochromocytoma, and parathyroid gland cancer. It may also cause benign (noncancerous) tumors in the adrenal glands and growths around the nerves in the lips, tongue, lining of the mouth, and eyelids. Gastrointestinal symptoms and trouble with the spine or bones in the feet and thighs may also occur. Multiple endocrine neoplasia type 2B syndrome is caused by a mutation (change) in a gene called RET. Also called MEN2B, MEN2B syndrome, and multiple endocrine adenomatosis type 2B.