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NCI Dictionary of Cancer Terms


liposome-encapsulated irinotecan hydrochloride PEP02  listen  (LY-poh-some-en-KAP-soo-lay-ted I-rih-noh-TEE-kan HY-droh-KLOR-ide …)

  A form of the anticancer drug irinotecan hydrochloride that is contained inside very tiny, fat-like particles. It is being studied in the treatment of colorectal cancer that has spread to other parts of the body and in other types of cancer. Irinotecan hydrochloride blocks cell division and DNA repair, and it may kill cancer cells. Liposome-encapsulated irinotecan hydrochloride PEP02 may have fewer side effects and work better than irinotecan hydrochloride. It is a type of topoisomerase inhibitor and a type of camptothecin analog. Also called PEP02.