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NCI Dictionary of Cancer Terms

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NCI Dictionary of Cancer Terms



stage II esophageal squamous cell carcinoma  listen  (... ee-SAH-fuh-JEE-ul SKWAY-mus sel KAR-sih-NOH-muh)

  Stage II is divided into stages IIA and IIB, depending on where the cancer has spread. In stage IIA, cancer has spread (1) into the middle (muscle) layer or the outer (connective tissue) layer of the esophageal wall. The tumor cells look a lot like normal cells under a microscope. The tumor is in either the upper or middle esophagus; or (2) into the middle (muscle) layer or the outer (connective tissue) layer of the esophageal wall. The tumor cells do not look at all like normal cells under a microscope. The tumor is in the lower esophagus or it is not known where the tumor is. In stage IIB, cancer (1) has spread into the middle (muscle) layer or the outer (connective tissue) layer of the esophageal wall. The tumor cells do not look at all like normal cells under a microscope. The tumor is in either the upper or middle esophagus; or (2) is in the inner (mucosal) layer and may have spread into the middle (muscle) layer of the esophageal wall. Cancer is found in 1 or 2 lymph nodes near the tumor.

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Stage IIA squamous cell cancer of the esophagus (1); drawing shows the esophagus and stomach. An inset shows the layers of the esophagus wall with cancer in the mucosa, submucosa, muscle, and connective tissue layers. Also shown are lymph nodes.
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Stage IIA squamous cell cancer of the esophagus (2); drawing shows the esophagus and stomach. An inset shows the layers of the esophagus wall with cancer in the mucosa, submucosa, muscle, and connective tissue layers. Also shown are lymph nodes.
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Stage IIB squamous cell cancer of the esophagus; drawing shows the esophagus and stomach. A two-panel inset shows the layers of the esophagus wall: the mucosa, submucosa, muscle, and connective tissue layers. The left panel shows cancer in the mucosa, submucosa, muscle, and connective tissue layers. The right panel shows cancer in the mucosa, submucosa, and muscle layers and in 1 lymph node.