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NCI Dictionary of Cancer Terms

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NCI Dictionary of Cancer Terms



peroxisome proliferator-activated receptor gamma pathway  listen  (peh-ROK-sih-some proh-LIH-feh-RAY-ter-AK-tih-vay-ted reh-SEP-ter GA-muh PATH-way)

  Describes a group of proteins in a cell that work together to help control how certain genes are expressed and the use of lipids (fats) and glucose (sugar) in the body. Changes in the peroxisome proliferator-activated receptor gamma pathway may lead to diseases such as heart disease, diabetes, and cancer. Drugs or substances that affect this pathway are being studied in the prevention and treatment of cancer and other diseases. Also called PPAR gamma pathway.