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NCI Dictionary of Cancer Terms


LXR alpha pathway  listen  (… AL-fuh PATH-way)

  Describes a group of proteins in a cell that work together to help control how certain genes are expressed and how cholesterol, lipids (fats), bile acids, and steroid hormones are made in the body. Changes in the LXR alpha pathway may lead to diseases such as heart disease and cancer. Drugs or substances that affect this pathway are being studied in the prevention and treatment of cancer and other diseases. Also called liver X receptor alpha pathway.