NCI Dictionary of Cancer Terms
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hereditary breast and ovarian cancer syndrome (heh-REH-dih-tayr-ee brest … oh-VAYR-ee-un KAN-ser SIN-drome)
An inherited disorder in which the risk of breast cancer (especially before the age of 50) and ovarian cancer is higher than normal. Most cases of hereditary breast and ovarian cancer syndrome are caused by certain mutations (changes) in the BRCA1 or the BRCA2 gene. People with hereditary breast and ovarian cancer syndrome may also have an increased risk of other types of cancer, including pancreatic cancer, prostate cancer, and melanoma. Also called HBOC syndrome.