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NCI Dictionary of Cancer Terms

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cold knife cone biopsy  listen  (kold nife kone BY-op-see)

  A procedure in which a cone-shaped piece of abnormal tissue is removed from the cervix using a scalpel or laser knife. Some of the tissue is then checked under a microscope for signs of disease, such as cervical cancer. Cold knife cone biopsy may also be used to treat certain cervical conditions. Also called cold knife conization.