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NCI Dictionary of Cancer Terms

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NCI Dictionary of Cancer Terms


663 results found for:       A



A33      
A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.

A6      
A substance being studied in the treatment of cancer. A6 is a small piece of a protein called urokinase (an enzyme that dissolves blood clots or prevents them from forming). It is a type of antiangiogenesis agent and a type of antimetastatic agent. Also called urokinase plasminogen activator (uPA)-derived peptide A6.

AAP      
An enzyme that is normally found in healthy kidneys. It may be found at high levels in the urine when there are kidney problems. It is used as a biomarker to detect damage to the kidneys caused by drugs and other agents. It may also be used to diagnose certain kidney and liver disorders. Also called alanine aminopeptidase.

abarelix    listen   (uh-BAYR-eh-lix)
A drug used to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available. It belongs to the family of drugs called gonadotropin-releasing hormone (GnRH) antagonists. Also called Plenaxis.

ABCA1 pathway    listen   (… PATH-way)
Describes a group of proteins in a cell that work together to help remove extra cholesterol and certain fats from tissue in the body. Changes in the ABCA1 pathway may lead to diseases of the heart and blood vessels. Drugs or substances that affect this pathway are being studied in the prevention and treatment of some diseases.

ABCD rating    listen   (... RAY-ting)
A staging system for prostate cancer that uses ABCD. “A” and “B” refer to cancer that is confined to the prostate. “C” refers to cancer that has grown out of the prostate but has not spread to lymph nodes or other places in the body. “D” refers to cancer that has spread to lymph nodes or to other places in the body. Also called Jewett staging system and Whitmore-Jewett staging system.

abdomen    listen   (AB-doh-men)
The area of the body that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs.

abdominal    listen   (ab-DAH-mih-nul)
Having to do with the abdomen, which is the part of the body between the chest and the hips that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs.

abdominal ultrasound    listen   (ab-DAH-mih-nul UL-truh-sownd)
A procedure used to examine the organs in the abdomen. An ultrasound transducer (probe) is pressed firmly against the skin of the abdomen. High-energy sound waves from the transducer bounce off tissues and create echoes. The echoes are sent to a computer, which makes a picture called a sonogram. Also called transabdominal ultrasound.

abdominal x-ray    listen   (ab-DAH-mih-nul EX-ray)
An x-ray of the organs inside the abdomen. An x-ray is a type of radiation that can pass through the body and onto film, making pictures of areas inside the body. X-rays may be used to help diagnose disease.

abdominoperineal resection    listen   (ab-DAH-mih-noh-PAYR-ih-NEE-ul ree-SEK-shun)
Surgery to remove the anus, the rectum, and part of the sigmoid colon through an incision made in the abdomen. The end of the intestine is attached to an opening in the surface of the abdomen and body waste is collected in a disposable bag outside of the body. This opening is called a colostomy. Lymph nodes that contain cancer may also be removed during this operation.

Abegrin    listen   (A-beh-grin)
A substance being studied in the treatment of some types of cancer and other conditions. Abegrin binds to a protein on the surface of blood vessels and may prevent the growth of new blood vessels that tumors need to grow. It may also prevent the spread of cancer. It is a type of antiangiogenesis agent, a type of metastasis inhibitor, and a type of monoclonal antibody. Also called etaracizumab, humanized monoclonal antibody MEDI-522, and MEDI-522.

aberrant crypt foci    listen   (uh-BAYR-unt kript FOH-sy)
Clusters of abnormal tube-like glands in the lining of the colon and rectum. Aberrant crypt foci form before colorectal polyps and are one of the earliest changes that can be seen in the colon that may lead to cancer. Also called ACF.

ABI-007      
A drug used to treat breast cancer that has come back or spread to other parts of the body. It is also used with carboplatin to treat advanced non-small cell lung cancer in patients who are not able to have surgery or radiation therapy. It is also used with gemcitabine hydrochloride to treat pancreatic cancer that has spread to other parts of the body. It is being studied in the treatment of other types of cancer. ABI-007 is a form of the anticancer drug paclitaxel and may cause fewer side effects than paclitaxel. It stops cancer cells from growing and dividing, and may kill them. It is a type of mitotic inhibitor and a type of antimicrotubule agent. Also called Abraxane, nanoparticle paclitaxel, paclitaxel albumin-stabilized nanoparticle formulation, and protein-bound paclitaxel.

abiraterone acetate    listen   (A-bih-RA-teh-rone A-seh-tayt)
A drug used with prednisone to treat prostate cancer that has spread to other parts of the body and has not gotten better with other hormone therapy. It is also being studied in the treatment of other types of cancer. Abiraterone acetate lowers the amount of androgens (male hormones), such as testosterone, made by the body. This may stop the growth of cancer cells that need androgens to grow. Abiraterone acetate is a type of antiandrogen. Also called Zytiga.

ablation    listen   (a-BLAY-shun)
In medicine, the removal or destruction of a body part or tissue or its function. Ablation may be performed by surgery, hormones, drugs, radiofrequency, heat, or other methods.

abnormal    listen   (ab-NOR-mul)
Not normal. Describes a state, condition, or behavior that is unusual or different from what is considered normal. An abnormal lesion or growth in or on the body may be benign (not cancer), precancerous or premalignant (likely to become cancer), or malignant (cancer).

ABO blood group system    listen   (… blud groop SIS-tem)
A system used to group human blood into different types, based on the presence or absence of certain markers on the surface of red blood cells. The four main blood types are A, B, O, and AB. For a blood transfusion, the ABO blood group system is used to match the blood type of the donor and the person receiving the transfusion. People with blood type O can donate blood to anyone and are called universal donors. People with blood type AB can accept blood from all donors and are called universal recipients. People with type A or B can receive matching blood or type O blood.

ABR test    listen   (... test)
A test used to detect some types of hearing loss, such as hearing loss caused by injury or tumors that affect nerves involved in hearing. Electrodes are placed on the head and certain tones or clicking sounds are made. The electrodes measure nerve signals in the brain when it reacts to the sounds. Also called auditory brain stem response test, BAER test, and brain stem auditory evoked response test.

Abraxane    listen   (uh-BRAK-sayn)
A drug used to treat breast cancer that has come back or spread to other parts of the body. It is also used with carboplatin to treat advanced non-small cell lung cancer in patients who are not able to have surgery or radiation therapy. It is also used with gemcitabine hydrochloride to treat pancreatic cancer that has spread to other parts of the body. It is being studied in the treatment of other types of cancer. Abraxane is a form of the anticancer drug paclitaxel and may cause fewer side effects than paclitaxel. It stops cancer cells from growing and dividing, and may kill them. It is a type of mitotic inhibitor and a type of antimicrotubule agent. Also called ABI-007, nanoparticle paclitaxel, paclitaxel albumin-stabilized nanoparticle formulation, and protein-bound paclitaxel.

abscess    listen   (AB-ses)
An enclosed collection of pus in tissues, organs, or confined spaces in the body. An abscess is a sign of infection and is usually swollen and inflamed.

absolute neutrophil count    listen   (AB-soh-loot NOO-troh-fil kownt)
A measure of the number of neutrophils in the blood. Neutrophils are a type of white blood cell. They help the body fight infection. An absolute neutrophil count may be used to check for infection, inflammation, leukemia, and other conditions. The lower a person's absolute neutrophil count is, the higher the risk is of getting an infection. Having an absolute neutrophil count of less than 500 means there is a high risk of getting an infection. Cancer treatment, such as chemotherapy, may reduce the absolute neutrophil count. Also called ANC.

absolute risk    listen   (AB-soh-loot risk)
A measure of the risk of a certain event happening. In cancer research, it is the likelihood that a person who is free of a specific type of cancer at a given age will develop that cancer over a certain period of time. For example, a woman 35 years of age, with no known risk factors for breast cancer, has an absolute risk of getting breast cancer over a lifetime of 90 years of about 13.5%, meaning one out of every seven women will develop breast cancer.

absorption    listen   (ub-SORP-shun)
The process of taking nutrients from the digestive system into the blood so they can be used in the body.

ABT-263      
A substance being studied in the treatment of lymphomas and other types of cancer. It blocks some of the enzymes that keep cancer cells from dying. It is a type of Bcl-2 family inhibitor. Also called navitoclax.

ABT-510      
A substance being studied in the treatment of cancer. It is a type of angiogenesis inhibitor.

ABT-751      
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called sulfonamides.

ABT-869      
A substance being studied in the treatment of several types of cancer. ABT-869 blocks the action of several growth factors. It may also block the growth of new blood vessels that tumors need to grow and may cause cancer cells to die. It is a type of receptor tyrosine kinase inhibitor and a type of angiogensis inhibitor. Also called multitargeted receptor tyrosine kinase inhibitor ABT-869.

ABT-888      
A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. ABT-888 may cause cancer cells to die. It is a type of poly(ADP-ribose) polymerase inhibitor. Also called PARP-1 inhibitor ABT-888 and veliparib.

ABVD      
An abbreviation for a chemotherapy combination used to treat Hodgkin lymphoma. It includes the drugs doxorubicin hydrochloride (Adriamycin), bleomycin sulfate, vinblastine sulfate, and dacarbazine. Also called ABVD regimen.

ABVD regimen    listen   (… REH-jih-men)
An abbreviation for a chemotherapy combination used to treat Hodgkin lymphoma. It includes the drugs doxorubicin hydrochloride (Adriamycin), bleomycin sulfate, vinblastine sulfate, and dacarbazine. Also called ABVD.

ABVE      
An abbreviation for a chemotherapy combination used with radiation therapy to treat childhood Hodgkin lymphoma. It includes the drugs doxorubicin hydrochloride (Adriamycin), bleomycin sulfate, vincristine sulfate, and etoposide. Also called ABVE regimen, DBVE, and DBVE regimen.

ABVE regimen    listen   (… REH-jih-men)
An abbreviation for a chemotherapy combination used with radiation therapy to treat childhood Hodgkin lymphoma. It includes the drugs doxorubicin hydrochloride (Adriamycin), bleomycin sulfate, vincristine sulfate, and etoposide. Also called ABVE, DBVE, and DBVE regimen.

ABVE-PC      
An abbreviation for a chemotherapy combination used with radiation therapy to treat childhood Hodgkin lymphoma. It includes the drugs doxorubicin hydrochloride (Adriamycin), bleomycin sulfate, vincristine sulfate, etoposide, prednisone, and cyclophosphamide. Also called ABVE-PC regimen, DBVE-PC, and DBVE-PC regimen.

ABVE-PC regimen    listen   (… REH-jih-men)
An abbreviation for a chemotherapy combination used with radiation therapy to treat childhood Hodgkin lymphoma. It includes the drugs doxorubicin hydrochloride (Adriamycin), bleomycin sulfate, vincristine sulfate, etoposide, prednisone, and cyclophosphamide. Also called ABVE-PC, DBVE-PC, and DBVE-PC regimen.

ABX-EGF      
A human monoclonal antibody that is being used to treat colorectal cancer that has spread to other parts of the body. It is used in patients whose disease has not gotten better during or after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. ABX-EGF binds to the epidermal growth factor receptor (EGFR) and may block tumor cell growth. Also called panitumumab and Vectibix.

AC      
An abbreviation for a chemotherapy combination used with other types of therapy to treat breast cancer, including breast cancer that has spread or come back. It includes the drugs doxorubicin hydrochloride (Adriamycin) and cyclophosphamide. Also called AC regimen.

AC regimen    listen   (… REH-jih-men)
An abbreviation for a chemotherapy combination used with other types of therapy to treat breast cancer, including breast cancer that has spread or come back. It includes the drugs doxorubicin hydrochloride (Adriamycin) and cyclophosphamide. Also called AC.

AC-T      
An abbreviation for a chemotherapy combination used to treat breast cancer. It includes the drugs doxorubicin hydrochloride (Adriamycin) and cyclophosphamide, followed by treatment with paclitaxel (Taxol). Also called AC-T regimen and AC-Taxol regimen.

AC-T regimen    listen   (… REH-jih-men)
An abbreviation for a chemotherapy combination used to treat breast cancer. It includes the drugs doxorubicin hydrochloride (Adriamycin) and cyclophosphamide, followed by treatment with paclitaxel (Taxol). Also called AC-T and AC-Taxol regimen.

AC-T-T      
An abbreviation for a chemotherapy combination used to treat breast cancer. It includes the drugs doxorubicin hydrochloride (Adriamycin) and cyclophosphamide, followed by treatment with paclitaxel (Taxol) and trastuzumab (Herceptin). Also called AC-T-T regimen, AC-TH regimen, and sequential AC/Taxol-Trastuzumab regimen.

AC-T-T regimen    listen   (… REH-jih-men)
An abbreviation for a chemotherapy combination used to treat breast cancer. It includes the drugs doxorubicin hydrochloride (Adriamycin) and cyclophosphamide, followed by treatment with paclitaxel (Taxol) and trastuzumab (Herceptin). Also called AC-T-T, AC-TH regimen, and sequential AC/Taxol-Trastuzumab regimen.

AC-Taxol regimen    listen   (… TAK-sol REH-jih-men)
An abbreviation for a chemotherapy combination used to treat breast cancer. It includes the drugs doxorubicin hydrochloride (Adriamycin) and cyclophosphamide, followed by treatment with paclitaxel (Taxol). Also called AC-T and AC-T regimen.

AC-TH regimen    listen   (… REH-jih-men)
An abbreviation for a chemotherapy combination used to treat breast cancer. It includes the drugs doxorubicin hydrochloride (Adriamycin) and cyclophosphamide, followed by treatment with paclitaxel (Taxol) and trastuzumab (Herceptin). Also called AC-T-T, AC-T-T regimen, and sequential AC/Taxol-Trastuzumab regimen.

ACAPHA    listen   (a-KA-fuh)
A mixture of six herbs that has been used in China to prevent and treat diseases such as lung and esophageal cancers. It is being studied in the United States and Canada in the prevention of lung cancer in people who used to smoke.

accelerated partial-breast irradiation    listen   (ak-SEH-leh-ray-ted PAR-shul-brest ih-RAY-dee-AY-shun)
A type of radiation therapy given only to the part of the breast that has cancer in it. Accelerated partial-breast irradiation gives a higher dose over a shorter time than is given in standard whole-breast radiation therapy. Accelerated partial-breast irradiation may be given using internal or external sources of radiation. Also called partial-breast irradiation.

accelerated phase chronic myelogenous leukemia    listen   (ak-SEH-leh-ray-ted fayz KRAH-nik MY-eh-LAH-jeh-nus loo-KEE-mee-uh)
A phase of chronic myelogenous leukemia in which the disease is progressing. In this phase, 10% to 19% of the cells in the blood and bone marrow are blast cells (immature blood cells).

accelerated radiation therapy    listen   (ak-SEH-leh-ray-ted RAY-dee-AY-shun THAYR-uh-pee)
Radiation treatment in which the total dose of radiation is given over a shorter period of time (fewer days) compared to standard radiation therapy.

accelerated-fraction radiation therapy    listen   (ak-SEH-leh-ray-ted-FRAK-shun RAY-dee-AY-shun THAYR-uh-pee)
Radiation treatment in which the total dose of radiation is divided into small doses and the treatments are given more than once a day. The total dose of radiation is also given over a shorter period of time (fewer days) compared to standard radiation therapy.

Accolate    listen   (A-koh-layt)
A drug used to prevent and treat symptoms of asthma. It blocks substances that cause inflammation in the lungs. It is a type of antiasthmatic agent and a leukotriene receptor antagonist. Also called zafirlukast.

ACE inhibitor    listen   (... in-HIH-bih-ter)
A drug that is used to lower blood pressure. An ACE inhibitor is a type of antihypertensive agent. Also called angiotensin-converting enzyme inhibitor.

acetaminophen    listen   (uh-see-tuh-MIH-nuh-fen)
A drug that reduces pain and fever (but not inflammation). It belongs to the family of drugs called analgesics.

acetate    listen   (A-seh-tayt)
A form of acetic acid (an acid found in vinegar).

acetic acid    listen   (uh-SEE-tik A-sid)
An acid found in vinegar. Acetic acid is also used to dissolve substances needed to make some medicines and other products, such as plastics.

acetone    listen   (A-seh-tone)
A chemical substance found naturally in small amounts in plants, trees, volcanoes, and forest fires. Acetone is also made by the body when fats are broken down. It is also found in tobacco smoke, car exhaust, and trash landfills. In industry, acetone is used in some plastics, fibers, medicines, household cleaners, glues, and nail polish removers. Being exposed to high levels of acetone may irritate the skin, eyes, nose, throat, and lungs. It can cause headaches, nausea, vomiting, dizziness, confusion, loss of consciousness, and other health problems.

acetyl group    listen   (A-seh-til groop)
A small molecule made of two carbon, three hydrogen, and one oxygen atoms. Acetyl groups are added to or removed from other molecules and may affect how the molecules act in the body.

acetyl-L-carnitine    listen   (A-seh-til ... KAR-nih-teen)
A form of the natural substance carnitine that is being studied as a way to prevent tissue damage caused by chemotherapy. Carnitine is made in muscle and liver tissue and is found in certain foods, such as meat, poultry, fish, and some dairy products. It is used by many cells in the body to make energy from fat. Also called acetyl-L-carnitine hydrochloride and ALCAR.

acetyl-L-carnitine hydrochloride    listen   (A-seh-til ... KAR-nih-teen HY-droh-KLOR-ide)
A form of the natural substance carnitine that is being studied as a way to prevent tissue damage caused by chemotherapy. Carnitine is made in muscle and liver tissue and is found in certain foods, such as meat, poultry, fish, and some dairy products. It is used by many cells in the body to make energy from fat. Also called acetyl-L-carnitine and ALCAR.

acetylation    listen   (a-SEH-tih-LAY-shun)
A chemical reaction in which a small molecule called an acetyl group is added to other molecules. Acetylation of proteins may affect how they act in the body.

acetylcholine    listen   (A-seh-til-KOH-leen)
A chemical made by some types of nerve cells. It is used to send messages to other cells, including other nerve cells, muscle cells, and gland cells. It is released from the nerve ending and carries signals to cells on the other side of a synapse (space between nerve cells and other cells). Acetylcholine helps control memory and the action of certain muscles. It is a type of neurotransmitter.

acetylcysteine    listen   (A-seh-til-SIS-teh-een)
A drug usually used to reduce the thickness of mucus and ease its removal. It is also used to reverse the toxicity of high doses of acetaminophen. Also called N-acetyl-L-cysteine and N-acetylcysteine.

ACF      
Clusters of abnormal tube-like glands in the lining of the colon and rectum. ACF form before colorectal polyps and are one of the earliest changes that can be seen in the colon that may lead to cancer. Also called aberrant crypt foci.

achlorhydria    listen   (ay-klor-HY-dree-uh)
A lack of hydrochloric acid in the digestive juices in the stomach. Hydrochloric acid helps digest food.

acid    listen   (A-sid)
A chemical that gives off hydrogen ions in water and forms salts by combining with certain metals. Acids have a sour taste and turn certain dyes red. Some acids made by the body, such as gastric acid, can help organs work the way they should. An example of an acid is hydrochloric acid. Acidity is measured on a scale called the pH scale. On this scale, a value of 7 is neutral, and a pH value of less than 7 to 0 shows increasing acidity.

acid-base balance    listen   (A-sid-bays BA-lunts)
In medicine, the state of having the right amount of acid and base in the blood and other body fluids. Keeping a normal acid-base balance is important for the body to work the way it should. Also called acid-base equilibrium.

acid-base equilibrium    listen   (A-sid-bays EE-kwuh-LIH-bree-um)
In medicine, the state of having the right amount of acid and base in the blood and other body fluids. Keeping a normal acid-base equilibrium is important for the body to work the way it should. Also called acid-base balance.

acidification    listen   (a-SIH-dih-fih-KAY-shun)
The process of making or becoming an acid. An acid is a substance that gives off hydrogen ions in water and forms salts by combining with certain metals.

acidity    listen   (a-SIH-dih-tee)
Describes the amount of acid in a substance. An acid is a chemical that gives off hydrogen ions in water and forms salts by combining with certain metals. Acidity is measured on a scale called the pH scale. On this scale, a pH value of 7 is neutral, and a pH value of less than 7 to 0 shows increasing acidity.

acitretin    listen   (A-sih-TREH-tin)
A substance that is used in the prevention of cancer and in the treatment of psoriasis. It belongs to the family of drugs called retinoids.

ACN53      
A substance that has been studied in the treatment of some types of cancer. ACN53 is a weakened adenovirus that carries the p53 gene into tumor cells, causing them to die. It is a type of gene therapy. Also called rAd/p53, recombinant adenovirus-p53, and SCH-58500.

acne    listen   (AK-nee)
A disorder of the skin in which oil glands and hair glands become inflamed.

acolbifene hydrochloride    listen   (ay-KOLE-bih-feen HY-droh-KLOR-ide)
A substance being studied in the prevention of breast cancer in women at high risk of breast cancer. Acolbifene hydrochloride binds to estrogen receptors in the body and blocks the effects of estrogen in the breast. It is a type of selective estrogen receptor modulator (SERM).

acoustic    listen   (uh-KOOS-tik)
Having to do with sound or hearing.

acoustic neurofibromatosis    listen   (uh-KOOS-tik NOOR-oh-fy-broh-muh-TOH-sis)
A genetic condition in which tumors form on the nerves of the inner ear and cause loss of hearing and balance. Tumors may also occur in the brain and on nerves in the skull and spinal cord, and may cause loss of speech, eye movement, and the ability to swallow. Also called neurofibromatosis type 2 and NF2.

acquired immunodeficiency syndrome    listen   (uh-KWY-erd IH-myoo-noh-dih-FIH-shun-see SIN-drome)
A disease caused by human immunodeficiency virus (HIV). People with acquired immunodeficiency syndrome are at an increased risk for developing certain cancers and for infections that usually occur only in individuals with a weak immune system. Also called AIDS.

acquired pure red cell aplasia    listen   (uh-KWY-erd … sel uh-PLAY-zhuh)
A rare disorder in which the bone marrow makes almost no red blood cells. It may be caused by infection or by certain drugs. Patients with this disorder may also have a thymoma (a tumor of the thymus) or an autoimmune condition such as lupus erythematosus or rheumatoid arthritis.

acridine carboxamide    listen   (A-krih-deen kar-BOK-suh-mide)
A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor. Also called DACA.

acromegaly    listen   (A-kroh-MEH-guh-lee)
A condition in which the pituitary gland makes too much growth hormone after normal growth of the skeleton is finished. This causes the bones of the hands, feet, head, and face to grow larger than normal. Acromegaly can be caused by a pituitary gland tumor.

acrylonitrile    listen   (ak-rih-loh-NY-tril)
A substance used to make plastics, rubber, and textiles. Being exposed to acrylonitrile may increase the risk of developing certain cancers, such as lung, brain, or prostate cancer.

ACTH      
A hormone made in the pituitary gland. ACTH acts on the outer part of the adrenal gland to control its release of corticosteroid hormones. More ACTH is made during times of stress. Also called adrenocorticotropic hormone and corticotropin.

Actinex    listen   (AK-tih-nex)
A drug put on the skin to treat growths caused by sun exposure. A form of Actinex that is taken by mouth is being studied in the treatment of prostate cancer. Actinex is an antioxidant, and it may block certain enzymes needed for tumor growth. Also called masoprocol, NDGA, and nordihydroguaiaretic acid.

actinic keratosis    listen   (ak-TIH-nik KAYR-uh-TOH-sis)
A thick, scaly patch of skin that may become cancer. It usually forms on areas exposed to the sun, such as the face, scalp, back of the hands, or chest. It is most common in people with fair skin. Also called senile keratosis and solar keratosis.

actinomycin D    listen   (AK-tih-noh-MY-sin …)
A drug used to treat Ewing sarcoma, gestational trophoblastic tumor, Wilms tumor, and certain types of testicular cancer. It is also used to treat rhabdomyosarcoma in children. It is being studied in the treatment of other types of cancer. Actinomycin D comes from the bacterium Streptomyces parvulus. It damages the cell’s DNA and may kill cancer cells. It is a type of anticancer antibiotic. Also called Cosmegen and dactinomycin.

action study    listen   (AK-shun STUH-dee)
In cancer prevention clinical trials, a study that focuses on finding out whether actions people take can prevent cancer.

Activase    listen   (AK-tih-vays)
A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent. Also called Alteplase, r-tPA, and recombinant tissue plasminogen activator.

activate    listen   (AK-tih-vayt)
In biology, to stimulate a cell in a resting state to become active. This causes biochemical and functional changes in the activated cell.

active surveillance    listen   (AK-tiv ser-VAY-lents)
A treatment plan that involves closely watching a patient’s condition but not giving any treatment unless there are changes in test results that show the condition is getting worse. Active surveillance may be used to avoid or delay the need for treatments such as radiation therapy or surgery, which can cause side effects or other problems. During active surveillance, certain exams and tests are done on a regular schedule. It may be used in the treatment of certain types of cancer, such as prostate cancer, urethral cancer, and intraocular (eye) melanoma. It is a type of expectant management.

activities of daily living    listen   (ak-TIH-vih-teez…DAY-lee LIH-ving)
The tasks of everyday life. These activities include eating, dressing, getting into or out of a bed or chair, taking a bath or shower, and using the toilet. Instrumental activities of daily living are activities related to independent living and include preparing meals, managing money, shopping, doing housework, and using a telephone. Also called ADL.

Actos    listen   (AK-tose)
A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth ) from developing into cancer. It is a type of thiazolidinedione. Also called pioglitazone.

acupoint    listen   (AK-yoo-poynt)
A specific spot on the body where an acupuncture needle may be inserted to control pain and other symptoms. Also called acupuncture point.

acupressure    listen   (AK-yoo-PREH-sher)
The application of pressure or localized massage to specific sites on the body to control symptoms such as pain or nausea. It is a type of complementary and alternative medicine.

acupuncture    listen   (AK-yoo-PUNK-cher)
The technique of inserting thin needles through the skin at specific points on the body to control pain and other symptoms. It is a type of complementary and alternative medicine.

acupuncture needle    listen   (AK-yoo-PUNK-cher NEE-dul)
A stainless steel needle that is slightly thicker than a human hair. Acupuncture needles are inserted through the skin at specific points on the body to control pain and other symptoms.

acupuncture point    listen   (AK-yoo-PUNK-cher poynt)
A specific spot on the body where an acupuncture needle may be inserted to control pain and other symptoms. Also called acupoint.

acupuncture point injection    listen   (AK-yoo-PUNK-cher poynt in-JEK-shun)
A procedure in which drugs, vitamins, herbal extracts, or other fluids are injected into the body at an acupuncture point using a syringe and needle.

acupuncture-like transcutaneous electrical nerve stimulation    listen   (AK-yoo-PUNK-cher-like tranz-kyoo-TAY-nee-us ee-LEK-trih-kul nerv STIM-yoo-LAY-shun)
A procedure in which mild electric currents are applied to certain acupuncture points (spots on the body where an acupuncture needle may be inserted to control pain and other symptoms) on the skin. It is being studied in the treatment of dry mouth caused by radiation therapy for cancer. Also called ALTENS.

acupuncturist    listen   (AK-yoo-PUNK-cheh-rist)
A person trained in acupuncture (therapy that uses thin needles inserted through the skin at specific points on the body to control pain and other symptoms). Acupuncture is a type of complementary and alternative medicine.

acustimulation    listen   (AK-yoo-STIM-yoo-LAY-shun)
Mild electrical stimulation of acupuncture points to control symptoms such as nausea and vomiting.

acute    listen   (uh-KYOOT)
Symptoms or signs that begin and worsen quickly; not chronic.

acute bacterial prostatitis    listen   (uh-KYOOT bak-TEER-ee-ul PROS-tuh-TY-tis)
Inflammation of the prostate gland that begins suddenly and gets worse quickly. It is caused by a bacterial infection. Symptoms include fever and chills, body aches, pain in the lower back and genital area, a burning feeling during urination, and problems with emptying the bladder all the way.

acute leukemia    listen   (uh-KYOOT loo-KEE-mee-uh)
A rapidly progressing cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of white blood cells to be produced and enter the blood stream.

acute lymphoblastic leukemia    listen   (uh-KYOOT LIM-foh-BLAS-tik loo-KEE-mee-uh)
An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called acute lymphocytic leukemia and ALL.

acute lymphocytic leukemia    listen   (uh-KYOOT LIM-foh-SIH-tik loo-KEE-mee-uh)
An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called acute lymphoblastic leukemia and ALL.

acute myeloblastic leukemia    listen   (uh-KYOOT MY-eh-loh-BLAS-tik loo-KEE-mee-uh)
An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. Also called acute myelogenous leukemia, acute myeloid leukemia, acute nonlymphocytic leukemia, AML, and ANLL.

acute myelogenous leukemia    listen   (uh-KYOOT MY-eh-LAH-jeh-nus loo-KEE-mee-uh)
An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. Also called acute myeloblastic leukemia, acute myeloid leukemia, acute nonlymphocytic leukemia, AML, and ANLL.

acute myeloid leukemia    listen   (uh-KYOOT MY-eh-loyd loo-KEE-mee-uh)
An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. Also called acute myeloblastic leukemia, acute myelogenous leukemia, acute nonlymphocytic leukemia, AML, and ANLL.

acute nonlymphocytic leukemia    listen   (uh-KYOOT non-LIM-foh-SIH-tik loo-KEE-mee-uh)
An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. Also called acute myeloblastic leukemia, acute myelogenous leukemia, acute myeloid leukemia, AML, and ANLL.

acute pain    listen   (uh-KYOOT payn)
Pain that comes on quickly, can be severe, but lasts a relatively short time.

acute promyelocytic leukemia    listen   (uh-KYOOT proh-MY-eh-loh-SIH-tik loo-KEE-mee-uh)
An aggressive (fast-growing) type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by an exchange of parts of chromosomes 15 and 17. Also called APL and promyelocytic leukemia.

acute radiation sickness    listen   (uh-KYOOT RAY-dee-AY-shun SIK-nes)
Serious illness caused by being exposed to high doses of certain types of radiation, usually over a short period of time. Symptoms of acute radiation sickness usually occur right after exposure but they may happen over time, and they may come and go. Symptoms include nausea and vomiting, diarrhea, headache, dizziness, weakness, fatigue, bleeding, hair loss, swelling, itching, and redness of the skin, and other skin problems. Very large doses of radiation may cause death. Also called acute radiation syndrome, radiation poisoning, radiation sickness, and radiation sickness syndrome.

acute radiation syndrome    listen   (uh-KYOOT RAY-dee-AY-shun SIN-drome)
Serious illness caused by being exposed to high doses of certain types of radiation, usually over a short period of time. Symptoms of acute radiation syndrome usually occur right after exposure but they may happen over time, and they may come and go. Symptoms include nausea and vomiting, diarrhea, headache, dizziness, weakness, fatigue, bleeding, hair loss, swelling, itching, and redness of the skin, and other skin problems. Very large doses of radiation may cause death. Also called acute radiation sickness, radiation poisoning, radiation sickness, and radiation sickness syndrome.

acyclovir    listen   (ay-SY-kloh-veer)
A substance used to prevent or treat cytomegalovirus and herpes simplex infections that may occur when the body is immunosuppressed. It belongs to the family of drugs called antivirals.

AD 32      
A drug used to treat bladder cancer that does not respond to BCG (Bacillus Calmette Guerin). It is an anthracycline and is a type of antitumor antibiotic. Also called valrubicin.

ADCC      
A type of immune reaction in which a target cell or microbe is coated with antibodies and killed by certain types of white blood cells. The white blood cells bind to the antibodies and release substances that kill the target cells or microbes. Also called antibody-dependent cell-mediated cytotoxicity and antibody-dependent cellular cytotoxicity.

Adcetris    listen   (ad-SEH-tris)
A drug used to treat Hodgkin lymphoma and systemic anaplastic large cell lymphoma that did not get better with other treatment. It is also being studied in the treatment of other types of lymphoma. Adcetris is made by combining a monoclonal antibody with an anticancer drug. It binds to a protein called CD30, which is on the surface of some lymphoma cells, and may kill cancer cells. Adcetris is a type of antibody-drug conjugate. Also called brentuximab vedotin and SGN-35.

Adderall    listen   (A-deh-rawl)
A combination of drugs used as a treatment for attention deficit hyperactivity disorder (ADHD) and narcolepsy (a sleep disorder). It is a type of stimulant. Also called dextroamphetamine-amphetamine.

addiction    listen   (uh-DIK-shun)
An uncontrollable craving, seeking, and use of a substance, such as a drug or alcohol.

Addison disease    listen   (A-dih-sun dih-ZEEZ)
A rare disorder in which the adrenal glands do not make enough of certain hormones. Symptoms include weight loss, loss of appetite, nausea and vomiting, diarrhea, muscle weakness, fatigue, low blood sugar, low blood pressure, and patchy or dark skin. Most cases of the disorder are caused by immune system problems, but may also be caused by infection, cancer, or other diseases. Also called adrenal insufficiency.

ADE      
An abbreviation for a chemotherapy combination used to treat childhood acute myeloid leukemia (AML). It includes the drugs cytarabine (Ara-C), daunorubicin hydrochloride, and etoposide phosphate. Also called ADE regimen.

ADE regimen    listen   (… REH-jih-men)
An abbreviation for a chemotherapy combination used to treat childhood acute myeloid leukemia (AML). It includes the drugs cytarabine (Ara-C), daunorubicin hydrochloride, and etoposide phosphate. Also called ADE.

adenine    listen   (A-deh-neen)
A chemical compound that is used to make one of the building blocks of DNA and RNA. It is also a part of many substances in the body that give energy to cells. Adenine is a type of purine.

adenocarcinoma    listen   (A-deh-noh-KAR-sih-NOH-muh)
Cancer that begins in glandular (secretory) cells. Glandular cells are found in tissue that lines certain internal organs and makes and releases substances in the body, such as mucus, digestive juices, or other fluids. Most cancers of the breast, pancreas, lung, prostate, and colon are adenocarcinomas.

adenocarcinoma in situ    listen   (A-deh-noh-KAR-sih-NOH-muh in SY-too)
A condition in which abnormal cells are found in the glandular tissue that lines certain internal organs, such as the uterus, cervix, lung, pancreas, and colon. Adenocarcinoma in situ, which occurs most often in the cervix, may become cancer and spread to nearby normal tissue. Also called AIS.

adenoid cystic carcinoma    listen   (A-deh-noyd SIS-tik KAR-sih-NOH-muh)
A rare type of cancer that usually begins in the salivary glands.

adenoma    listen   (A-deh-NOH-muh)
A tumor that is not cancer. It starts in gland-like cells of the epithelial tissue (thin layer of tissue that covers organs, glands, and other structures within the body).

adenopathy    listen   (A-deh-NAH-puh-thee)
Large or swollen lymph glands.

adenosarcoma    listen   (A-den-oh-sar-KOH-muh)
A tumor that is a mixture of an adenoma (a tumor that starts in the gland-like cells of epithelial tissue) and a sarcoma (a tumor that starts in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue). An example of an adenosarcoma is Wilms tumor.

adenosine triphosphate    listen   (uh-DEH-nuh-seen try-FOS-fayt)
A substance present in all living cells that provides energy for many metabolic processes and is involved in making RNA. Adenosine triphosphate made in the laboratory is being studied in patients with advanced solid tumors to see if it can decrease weight loss and improve muscle strength. Also called ATP.

adenosis    listen   (A-deh-NOH-sis)
A disease or abnormal change in a gland. Breast adenosis is a benign condition in which the lobules are larger than usual.

adenosquamous carcinoma    listen   (A-deh-noh-SKWAY-mus KAR-sih-NOH-muh)
A type of cancer that contains two types of cells: squamous cells (thin, flat cells that line certain organs) and gland-like cells.

adenovirus    listen   (A-den-oh-VY-rus)
A member of a family of viruses that can cause infections in the respiratory tract, eye, and gastrointestinal tract. Forms of adenoviruses that do not cause disease are used in gene therapy. They carry genes that may fix defects in cells or kill cancer cells.

ADH      
A benign (not cancer) condition in which there are more cells than normal in the lining of breast ducts and the cells look abnormal under a microscope. Having ADH increases the risk of breast cancer. Also called atypical ductal breast hyperplasia and atypical ductal hyperplasia.

ADI-PEG 20      
A substance being studied in the treatment of melanoma, liver cancer, and other types of cancer. It breaks down the amino acid arginine and may block the growth of cancer cells that need arginine to grow. It is a type of iminohydrolase. Also called pegylated arginine deiminase.

adjunct agent    listen   (A-junkt AY-jent)
In cancer therapy, a drug or substance used in addition to the primary therapy.

adjunct therapy    listen   (A-junkt THAYR-uh-pee)
Another treatment used together with the primary treatment. Its purpose is to assist the primary treatment. Also called adjunctive therapy.

adjunctive therapy    listen   (A-junk-tiv THAYR-uh-pee)
Another treatment used together with the primary treatment. Its purpose is to assist the primary treatment. Also called adjunct therapy.

adjustment disorder    listen   (uh-JUST-ment dis-OR-der)
A condition in which a person responds to a stressful event (such as an illness, job loss, or divorce) with extreme emotions and actions that cause problems at work and home.

adjuvant therapy    listen   (A-joo-vunt THAYR-uh-pee)
Additional cancer treatment given after the primary treatment to lower the risk that the cancer will come back. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, targeted therapy, or biological therapy.

ADL      
Activities of daily living. The tasks of everyday life. Basic ADLs include eating, dressing, getting into or out of a bed or chair, taking a bath or shower, and using the toilet. Instrumental activities of daily living (IADL) are activities related to independent living and include preparing meals, managing money, shopping, doing housework, and using a telephone. Also called activities of daily living.

administration    listen   (ad-MIH-nih-STRAY-shun)
In medicine, the act of giving a treatment, such as a drug, to a patient. It can also refer to the way it is given, the dose, or how often it is given.

adnexal mass    listen   (ad-NEK-sul…)
A lump in tissue near the uterus, usually in the ovary or fallopian tube. Adnexal masses include ovarian cysts, ectopic (tubal) pregnancies, and benign (not cancer) or malignant (cancer) tumors.

ado-trastuzumab emtansine    listen   (A-doh-tras-TOO-zoo-mab em-TAN-seen)
A drug used to treat HER2-positive breast cancer that has spread to other parts of the body. It is used in patients who have already been treated with the anticancer drug called trastuzumab and a type of drug called a taxane. It may also be used in patients whose cancer has recurred (come back) after adjuvant therapy with these drugs. It is also being studied in the treatment of other types of cancer. Ado-trastuzumab emtansine contains a monoclonal antibody called trastuzumab that binds to a protein called HER2, which is found on some breast cancer cells. It also contains an anticancer drug called DM1, which may help kill cancer cells. Ado-trastuzumab emtansine is a type of antibody-drug conjugate. Also called Kadcyla and T-DM1.

adoptive cellular therapy    listen   (uh-DOP-tiv SEL-yoo-ler THAYR-uh-pee)
A treatment used to help the immune system fight diseases, such as cancer and infections with certain viruses. T cells are collected from a patient and grown in the laboratory. This increases the number of T cells that are able to kill cancer cells or fight infections. These T cells are given back to the patient to help the immune system fight disease. Also called cellular adoptive immunotherapy.

adrenal cancer    listen   (uh-DREE-nul KAN-ser)
Cancer that forms in the tissues of the adrenal glands (two glands located just above the kidneys). The adrenal glands make hormones that control heart rate, blood pressure, and other important body functions. Adrenal cancer that starts in the outside layer of the adrenal gland is called adrenocortical carcinoma. Adrenal cancer that starts in the center of the adrenal gland is called malignant pheochromocytoma.

adrenal cortex    listen   (uh-DREE-nul KOR-tex)
The outer part of the adrenal gland (a small organ on top of each kidney). The adrenal cortex makes androgen and corticosteroid hormones.

adrenal gland    listen   (uh-DREE-nul...)
A small gland that makes steroid hormones, adrenaline, and noradrenaline. These hormones help control heart rate, blood pressure, and other important body functions. There are two adrenal glands, one on top of each kidney. Also called suprarenal gland.

adrenal insufficiency    listen   (uh-DREE-nul IN-suh-FIH-shen-see)
A rare disorder in which the adrenal glands do not make enough of certain hormones. Symptoms include weight loss, loss of appetite, nausea and vomiting, diarrhea, muscle weakness, fatigue, low blood sugar, low blood pressure, and patchy or dark skin. Most cases of the disorder are caused by immune system problems, but may also be caused by infection, cancer, or other diseases. Also called Addison disease.

adrenal medulla    listen   (uh-DREE-nul meh-DOO-luh)
The inner part of the adrenal gland (a small organ on top of each kidney). The adrenal medulla makes chemicals such as epinephrine (adrenaline) and norepinephrine (noradrenaline) which are involved in sending nerve signals.

adrenalectomy    listen   (uh-DREE-nul-EK-toh-mee)
Surgery to remove one or both adrenal glands (a small organ on top of each kidney).

adrenaline    listen   (uh-DREH-nuh-lin)
A hormone and neurotransmitter. Also called epinephrine.

adrenocortical    listen   (uh-DREE-noh-KOR-tih-kul)
Having to do with or made by the outer layer of the adrenal gland, which produces steroid hormones. There is an adrenal gland on top of each kidney.

adrenocortical cancer    listen   (uh-DREE-noh-KOR-tih-kul KAN-ser)
A rare cancer that forms in the outer layer of tissue of the adrenal gland (a small organ on top of each kidney that makes steroid hormones, adrenaline, and noradrenaline to control heart rate, blood pressure, and other body functions). Also called adrenocortical carcinoma and cancer of the adrenal cortex.

adrenocortical carcinoma    listen   (uh-DREE-noh-KOR-tih-kul KAR-sih-NOH-muh)
A rare cancer that forms in the outer layer of tissue of the adrenal gland (a small organ on top of each kidney that makes steroid hormones, adrenaline, and noradrenaline to control heart rate, blood pressure, and other body functions). Also called adrenocortical cancer and cancer of the adrenal cortex.

adrenocorticotropic hormone    listen   (uh-DREE-noh-KOR-tih-koh-TROH-pik HOR-mone)
A hormone made in the pituitary gland. Adrenocorticotropic hormone acts on the outer part of the adrenal gland to control its release of corticosteroid hormones. More adrenocorticotropic hormone is made during times of stress. Also called ACTH and corticotropin.

AdreView    listen   (A-dreh-VYOO)
A drug containing a form of radioactive iodine called I 123 that is used to detect certain types of tumors, including pheochromocytomas and neuroblastomas. Radiation from the I 123 may help show where cancer cells are in the body. AdreView is a type of radioimaging agent and a type of radioconjugate. Also called 123I-MIBG, iobenguane I 123, and iodine I 123 metaiodobenzylguanidine.

Adriamycin PFS    listen   (AY-dree-uh-MY-sin …)
A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Adriamycin PFS comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic. Also called Adriamycin RDF, doxorubicin, doxorubicin hydrochloride, hydroxydaunorubicin, and Rubex.

Adriamycin RDF    listen   (AY-dree-uh-MY-sin …)
A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. Adriamycin RDF comes from the bacterium Streptomyces peucetius. It damages DNA and may kill cancer cells. It is a type of anthracycline antitumor antibiotic. Also called Adriamycin PFS, doxorubicin, doxorubicin hydrochloride, hydroxydaunorubicin, and Rubex.

Adrucil    listen   (AD-roo-sil)
A drug used to treat cancers of the breast, stomach, and pancreas, and certain types of colorectal and head and neck cancers. It is also used in a cream to treat basal cell skin cancer and actinic keratosis (a skin condition that may become cancer). It is being studied in the treatment of other conditions and types of cancer. Adrucil stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite. Also called 5-fluorouracil, 5-FU, Efudex, Fluoroplex, and fluorouracil.

adult progeria    listen   (uh-DULT proh-JEER-ee-uh)
An inherited disorder marked by rapid aging that begins in early adolescence. Patients may be shorter than average, and have health problems such as loss and graying of hair, hardening of the arteries, thinning of the bones, diabetes, and thin, hardened skin. They also have an increased risk of cancer, especially osteosarcoma (a type of bone cancer). Adult progeria is caused by a mutation (change) in a gene involved in cell division. It is a type of autosomal recessive gene disease. Also called Werner syndrome and WS.

adult rickets    listen   (uh-DULT RIH-kets)
A condition in adults in which bones become soft and deformed because they don’t have enough calcium and phosphorus. It is usually caused by not having enough vitamin D in the diet, not getting enough sunlight, or a problem with the way the body uses vitamin D. Symptoms include bone pain and muscle weakness. When the condition occurs in children, it is called rickets. Also called osteomalacia.

adult T-cell leukemia/lymphoma    listen   (uh-DULT T-sel loo-KEE-mee-uh/lim-FOH-muh)
An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma caused by the human T-cell leukemia virus type 1 (HTLV-1). It is marked by bone and skin lesions, high calcium levels, and enlarged lymph nodes, spleen, and liver. Also called ATLL.

adulterant    listen   (uh-DUL-teh-runt)
A substance added to a product but not listed as an ingredient, or a substance that ends up in a product by accident when the product is made. Adulterants may be in foods, drugs, and other products. An adulterant may cause a product to be harmful, cheaper to make, or not work as it should.

advance directive    listen   (ad-VANS duh-REK-tiv)
A legal document that states the treatment or care a person wishes to receive or not receive if he or she becomes unable to make medical decisions (for example, due to being unconscious or in a coma). Some types of advance directives are living wills and do-not-resuscitate (DNR) orders.

advanced cancer    listen   (ad-VANST KAN-ser)
Cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment.

advanced practice nurse    listen   (ad-VANST PRAK-tis ...)
A registered nurse who has additional education and training in how to diagnose and treat disease. Advanced practice nurses are licensed at the state level and certified by national nursing organizations. In cancer care, an advanced practice nurse may manage the primary care of patients and their families, based on a practice agreement with a doctor. Also called APN, NP, and nurse practitioner.

adverse effect    listen   (AD-vers eh-FEKT)
An unexpected medical problem that happens during treatment with a drug or other therapy. Adverse effects do not have to be caused by the drug or therapy, and they may be mild, moderate, or severe. Also called adverse event.

adverse event    listen   (AD-vers eh-VENT)
An unexpected medical problem that happens during treatment with a drug or other therapy. Adverse events do not have to be caused by the drug or therapy, and they may be mild, moderate, or severe. Also called adverse effect.

Advil    listen   (AD-vil)
A drug used to treat fever, swelling, pain, and redness by preventing the body from making a substance that causes inflammation. It is a type of nonsteroidal anti-inflammatory drug (NSAID). Also called ibuprofen and Motrin.

AE-941      
A substance made from shark cartilage that is being studied for its ability to prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.

AEE788      
A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called protein tyrosine kinase inhibitors and angiogenesis inhibitors.

AEG35156      
A substance being studied in the treatment of cancer. AEG35156 may kill cancer cells by blocking the production of a protein called XIAP that helps cells live longer. It also makes cancer cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of chemosensitizing agent. Also called GEM640.

aerobic    listen   (ayr-OH-bik)
In biochemistry, reactions that need oxygen to happen or happen when oxygen is present.

aerobic exercise    listen   (ayr-OH-bik EK-ser-size)
Physical activity that increases the heart rate and the body’s use of oxygen. It helps improve a person’s physical fitness.

aerobic metabolism    listen   (ayr-OH-bik meh-TA-buh-lih-zum)
A chemical process in which oxygen is used to make energy from carbohydrates (sugars). Also called aerobic respiration, cell respiration, and oxidative metabolism.

aerobic respiration    listen   (ayr-OH-bik RES-pih-RAY-shun)
A chemical process in which oxygen is used to make energy from carbohydrates (sugars). Also called aerobic metabolism, cell respiration, and oxidative metabolism.

aerodigestive tract    listen   (ayr-OH-dy-JES-tiv trakt)
The combined organs and tissues of the respiratory tract and the upper part of the digestive tract (including the lips, mouth, tongue, nose, throat, vocal cords, and part of the esophagus and windpipe).

aerosolize    listen   (AYR-oh-sah-lize)
In medicine, to turn a liquid drug into a fine mist that can be inhaled.

afatinib dimaleate    listen   (ay-FA-tih-nib dy-MAY-lee-AYT)
A drug used to treat non-small cell lung cancer that has spread to other parts of the body. It is used in patients with certain mutations (changes) in a cell protein called epidermal growth factor receptor (EGFR). It is also being studied in the treatment of other types of cancer. Afatinib dimaleate blocks certain EGFRs, which may help keep cancer cells from growing. It may also prevent the growth of new blood vessels that tumors need to grow. Afatinib dimaleate is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent. Also called Gilotrif.

affinity    listen   (uh-FIH-nih-tee)
In chemistry and biology, the strength of the attaction between two substances, such as two chemicals, or an antigen and an antibody.

affinity reagent    listen   (uh-FIH-nih-tee ree-AY-jent)
In chemistry and biology, a compound that binds specific substances, such as proteins or nucleic acids. Many affinity reagents are antibodies. They are used to analyze tissue samples to help diagnose diseases.

Afinitor    listen   (uh-FIH-nih-tor)
A drug used with another drug to treat some postmenopausal women with advanced breast cancer that is hormone-receptor positive and HER2 negative. It is also used to treat certain types of pancreatic cancer, a type of advanced kidney cancer, and subependymal giant cell astrocytoma in some patients, including children. Afinitor is being studied in the treatment of other types of cancer. It stops cancer cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It also lowers the body’s immune response. It is a type of kinase inhibitor, a type of angiogenesis inhibitor, and a type of immunosuppressant. Also called Afinitor Disperz, everolimus, and RAD001.

Afinitor Disperz    listen   (uh-FIH-nih-tor DIS-perz)
A drug used with another drug to treat some postmenopausal women with advanced breast cancer that is hormone-receptor positive and HER2 negative. It is also used to treat certain types of pancreatic cancer, a type of advanced kidney cancer, and subependymal giant cell astrocytoma in some patients, including children. Afinitor Disperz is being studied in the treatment of other types of cancer. It stops cancer cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It also lowers the body’s immune response. It is a type of kinase inhibitor, a type of angiogenesis inhibitor, and a type of immunosuppressant. Also called Afinitor, everolimus, and RAD001.

aflatoxin    listen   (A-fluh-TOK-sin)
A harmful substance made by certain types of mold (Aspergillus flavus and Aspergillus parasiticus) that is often found on poorly stored grains and nuts. Consumption of foods contaminated with aflatoxin is a risk factor for primary liver cancer.

AFP      
A protein normally produced by a fetus. AFP levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of AFP suggests the presence of either a primary liver cancer or germ cell tumor. Also called alpha-fetoprotein.

AFP464      
A substance being studied in the treatment of cancer. AFP464 kills cancer cells or stops them from dividing. It is a type of aminoflavone.

AG-013736      
A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called angiogenesis inhibitors and protein tyrosine kinase inhibitors.

AG014699      
A substance being studied in the treatment of breast cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. AG014699 may cause cancer cells to die. It is a type of poly(ADP-ribose) polymerase inhibitor. Also called PARP-1 inhibitor AG014699.

AG2037      
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called glycinamide ribonucleotide formyl transferase inhibitors.

AG3340      
A substance that is being studied in the treatment of cancer. It is a matrix metalloproteinase inhibitor and belongs to the family of drugs called angiogenesis inhibitors. Also called prinomastat.

AG337      
A substance that is being studied in the treatment of liver cancer. It belongs to the family of drugs called thymidylate synthase inhibitors. Also called nolatrexed and Thymitaq.

aganglionic megacolon    listen   (ay-GANG-glee-AH-nik MEH-guh-KOH-lun)
A condition in which certain nerve cells are missing from the muscle layers of part of the large intestine. This causes severe constipation or blockage of the large intestine. Constipation is when stool becomes hard, dry, and difficult to pass and bowel movements occur less often than normal. Other symptoms include swollen abdomen, vomiting, bloody diarrhea, gas, lack of energy, and trouble gaining weight. Aganglionic megacolon is present from birth, but the symptoms may not appear until later in a child’s life. This condition has been linked to an increased risk of thyroid cancer and neuroblastoma. Also called Hirschsprung disease.

AGC      
A finding of abnormal cells in a Pap test. The glandular cells come from the inner part of the cervix or the lining of the uterus. This finding may be a sign of cancer or other serious condition, and more testing may be needed. Also called atypical glandular cells.

age-related macular degeneration    listen   (ayj-ree-LAY-ted MA-kyoo-ler dee-JEH-neh-RAY-shun)
A condition in which there is a slow breakdown of cells in the center of the retina (the light-sensitive layers of nerve tissue at the back of the eye). This blocks vision in the center of the eye and can cause problems with activities such as reading and driving. Age-related macular degeneration is most often seen in people who are over the age of 50. Also called AMD, ARMD, and macular degeneration.

agent study    listen   (AY-jent STUH-dee)
In cancer prevention, a clinical trial that studies whether taking certain medicines, vitamins, minerals, or food supplements can prevent cancer. Also called chemoprevention study.

agglutinin    listen   (uh-GLOO-tih-nin)
A substance that makes particles (such as bacteria or cells) stick together to form a clump or a mass.

aggravating factor    listen   (A-gruh-VAY-ting FAK-ter)
Something that makes a condition worse. For example, tobacco smoke is an aggravating factor for asthma.

aggressive    listen   (uh-GREH-siv)
In medicine, describes a tumor or disease that forms, grows, or spreads quickly. It may also describe treatment that is more severe or intense than usual.

aggressive lymphoma    listen   (uh-GREH-siv lim-FOH-muh)
A type of lymphoma that grows and spreads quickly and has severe symptoms. Also called high-grade lymphoma and intermediate-grade lymphoma.

agitation    listen   (A-jih-TAY-shun)
A condition in which a person is unable to relax and be still. The person may be very tense and irritable, and become easily annoyed by small things. He or she may be eager to have an argument, and be unwilling to work with caregivers to make the situation better.

agnogenic myeloid metaplasia    listen   (ag-noh-JEH-nik MY-eh-loyd meh-tuh-PLAY-zhuh)
A progressive, chronic disease in which the bone marrow is replaced by fibrous tissue and blood is made in organs such as the liver and the spleen, instead of in the bone marrow. This disease is marked by an enlarged spleen and progressive anemia. Also called chronic idiopathic myelofibrosis, idiopathic myelofibrosis, myelosclerosis with myeloid metaplasia, and primary myelofibrosis.

agonist    listen   (A-guh-nist)
A drug or substance that binds to a receptor inside a cell or on its surface and causes the same action as the substance that normally binds to the receptor.

agoraphobia    listen   (A-gor-uh-FOH-bee-uh)
An intense fear of being in open places or in situations where it may be hard to escape, or where help may not be available. People with agoraphobia are usually very anxious about having a panic attack in a public place. They may also have a fear of being alone or have trouble leaving their home. They usually avoid elevators, bridges, and public places. Agoraphobia is a type of phobia and a type of anxiety disorder.

agranulocyte    listen   (ay-GRAN-yoo-loh-SITE)
A type of white blood cell. Monocytes and lymphocytes are agranulocytes.

AGUS      
A term that has been used to describe abnormal cells that come from glands in the walls of the cervix (the lower, narrow end of the uterus). These abnormal cells are found in a small number of Pap smears (a procedure used to detect cervical cancer) and may be a sign of more serious lesions or cancer. The term used now is atypical glandular cells. Also called atypical glandular cells of uncertain significance and atypical glandular cells of undetermined significance.

AHA      
One of a group of substances that are found in several types of fruit and in milk. They are used in skin care products to reduce wrinkles and soften the skin. Examples of AHAs are glycolic acid, lactic acid, and citric acid. Also called alpha hydroxyl acid and fruit acid.

AIDS    listen  
A disease caused by the human immunodeficiency virus (HIV). People with AIDS are at an increased risk for developing certain cancers and for infections that usually occur only in individuals with a weak immune system. Also called acquired immunodeficiency syndrome.

AIDS-related cancer    listen   (… ree-LAY-ted KAN-ser)
Types of cancer that are more likely to occur in people who are infected with the human immunodeficiency virus (HIV). The most common AIDS-related cancers are Kaposi sarcoma, non-Hodgkin lymphoma, and cervical cancer. People infected with HIV who develop any one of these cancers are considered to have AIDS. Other less common types of AIDS-related cancers include cancers of the mouth, throat, liver, lung, colon, rectum, anus, testes, and skin.

AIS      
A condition in which abnormal cells are found in the glandular tissue that lines certain internal organs, such as the uterus, cervix, lung, pancreas, and colon. AIS, which occurs most often in the cervix, may become cancer and spread to nearby normal tissue. Also called adenocarcinoma in situ.

AJCC staging system    listen   (... STAY-jing SIS-tem)
A system to describe the amount and spread of cancer in a patient’s body, using TNM. T describes the size of the tumor and any spread of cancer into nearby tissue; N describes spread of cancer to nearby lymph nodes; and M describes metastasis (spread of cancer to other parts of the body). This system was created and is updated by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC). The AJCC staging system is used to describe most types of cancer. Also called TNM staging system.

Akt      
A group of enzymes involved in several processes related to cell growth and survival. Akt enzymes help to transfer signals inside cells. An Akt enzyme is a type of serine/threonine protein kinase. Also called protein kinase B.

Alagille syndrome    listen   (a-luh-JEEL SIN-drome)
A rare disorder in which there are defects in the small tubes that carry bile (fluid that helps digest fat) out of the liver. These small tubes may be narrow or have an abnormal shape, or there may be fewer of them than normal. This can cause bile to build up in the liver, which may lead to cirrhosis (scarring of the liver) and liver damage. Alagille syndrome can also affect other parts of the body, including the heart, kidneys, blood vessels, eyes, face, and spine. It usually occurs in infants and children and may be inherited.

alanine aminopeptidase    listen   (A-luh-neen uh-MEE-noh-PEP-tih-days)
An enzyme that is normally found in healthy kidneys. It may be found at high levels in the urine when there are kidney problems. It is used as a biomarker to detect damage to the kidneys caused by drugs and other agents. It may also be used to diagnose certain kidney and liver disorders. Also called AAP.

alanine transferase    listen   (A-luh-neen TRANZ-feh-rays)
An enzyme found in the liver and other tissues. A high level of alanine transferase released into the blood may be a sign of liver damage, cancer, or other diseases. Also called serum glutamate pyruvate transaminase and SGPT.

alanosine    listen   (uh-LAN-oh-seen)
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antimetabolites. Also called SDX-102.

albinism    listen   (AL-bih-NIH-zum)
A group of genetic conditions marked by little or none of the pigment melanin in the skin, hair, and/or eyes. People with albinism may have vision problems and white or yellow hair; reddish, violet, blue or brown eyes; and pale skin.

albumin    listen   (al-BYOO-min)
A type of protein found in blood, egg white, milk, and other substances.

ALCAR    listen   (ALL-kar)
A form of the natural substance carnitine that is being studied as a way to prevent tissue damage caused by chemotherapy. Carnitine is made in muscle and liver tissue and is found in certain foods, such as meat, poultry, fish, and some dairy products. It is used by many cells in the body to make energy from fat. Also called acetyl-L-carnitine and acetyl-L-carnitine hydrochloride.

ALCL      
An aggressive (fast-growing) type of non-Hodgkin lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver. Also called anaplastic large cell lymphoma.

alcohol    listen   (AL-kuh-hol)
A chemical substance found in drinks such as beer, wine, and liquor. It is also found in some medicines, mouthwashes, household products, and essential oils (scented liquid taken from certain plants). It is made by a chemical process called fermentation that uses sugars and yeast. There are different types of alcohol. The type used to make alcoholic drinks is called ethyl alcohol (ethanol). Drinking regular or large amounts of alcohol may increase the risk of certain types of cancer, such as cancer of the mouth, throat, esophagus, breast, liver, colon, and rectum.

alcohol ablation    listen   (AL-kuh-hol a-BLAY-shun)
An injection of ethanol (alcohol) through the skin directly into a tumor to kill cancer cells. Ultrasound or a CT scan is used to guide the needle into the tumor. Also called ethanol ablation, PEI, and percutaneous ethanol injection.

alcohol dependence    listen   (AL-kuh-hol dee-PEN-dents)
A chronic disease in which a person craves drinks that contain alcohol and is unable to control his or her drinking. A person with this disease also needs to drink greater amounts to get the same effect and has withdrawal symptoms after stopping alcohol use. Alcohol dependence affects physical and mental health, and can cause problems with family, friends, and work. Regular heavy alcohol intake increases the risk of several types of cancer. Also called alcoholism.

alcoholism    listen   (AL-kuh-HAW-LIH-zum)
A chronic disease in which a person craves drinks that contain alcohol and is unable to control his or her drinking. A person with this disease also needs to drink greater amounts to get the same effect and has withdrawal symptoms after stopping alcohol use. Alcoholism affects physical and mental health, and can cause problems with family, friends, and work. Regular heavy alcohol intake increases the risk of several types of cancer. Also called alcohol dependence.

Aldara    listen   (al-DAR-uh)
A drug used to treat early basal cell skin cancer and certain other skin conditions. It is being studied in the treatment of other types of cancer. Aldara is a type of biological response modifier. Also called imiquimod.

aldehyde    listen   (AL-deh-hide)
A type of chemical substance made from alcohol. Aldehydes are found in essential oils (scented liquid taken from plants).

aldesleukin    listen   (AL-des-LOO-kin)
A drug used to treat some types of cancer. It is a form of interleukin-2, a cytokine made by leukocytes (white blood cells), that is made in the laboratory. Aldesleukin increases the activity and growth of white blood cells called T lymphocytes and B lymphocytes. It is a type of biological response modifier. Also called Proleukin and recombinant human interleukin-2.

aldosterone    listen   (al-DOS-teh-rone)
A steroid hormone made by the adrenal cortex (the outer layer of the adrenal gland). It helps control the balance of water and salts in the kidney by keeping sodium in and releasing potassium from the body. Too much aldosterone can cause high blood pressure and a build-up of fluid in body tissues. Aldosterone is a type of mineralocorticoid hormone.

Aldrich syndrome    listen   (ALL-drich SIN-drome)
An inherited immune disorder that occurs in young boys. It causes eczema (a type of skin inflammation), a decrease in the number of platelets (blood cells that help prevent bleeding), and frequent bacterial infections. People with Aldrich syndrome are at increased risk of developing leukemia and lymphoma. Also called Wiskott-Aldrich syndrome.

alefacept    listen   (uh-LEH-fuh-sept)
A drug that is used to treat certain skin conditions and is being studied in the treatment of cutaneous (skin-related) T-cell cancer and T-cell non-Hodgkin lymphoma. Alefacept is made by combining part of an antibody with a protein that blocks the growth some types of T cells. It is a type of fusion protein and a type of immunosuppressant. Also called Amevive.

alemtuzumab    listen   (A-lem-TOO-zoo-mab)
A drug used to treat B-cell chronic lymphocytic leukemia. It is also being studied in the treatment of other types of cancer. Alemtuzumab binds to a protein called CD52, which is found on some types of immune cells and cancer cells. This may help the immune system kill cancer cells. Alemtuzumab is a type of monoclonal antibody. Also called Campath.

alendronate sodium    listen   (uh-LEN-droh-nayt SOH-dee-um)
A drug used to treat certain bone conditions, such as osteoporosis and Paget disease of the bone. It is also being studied in the treatment of hypercalcemia (high levels of calcium in the blood) and bone pain caused by cancer. Alendronate sodium slows the breakdown of bone and prevents the loss of calcium. It is a type of bisphosphonate. Also called Fosamax.

ALH      
A benign (not cancer) condition in which there are more cells than normal in the breast lobules and the cells look abnormal under a microscope. Having ALH increases the risk of breast cancer. Also called atypical lobular breast hyperplasia and atypical lobular hyperplasia.

Alimta    listen   (uh-LIM-tuh)
A drug used alone or with another drug to treat certain types of non-small cell lung cancer and malignant pleural mesothelioma. It is being studied in the treatment of other types of cancer. Alimta blocks DNA synthesis and may kill cancer cells. It is a type of folate antagonist. Also called LY231514 and pemetrexed disodium.

ALK gene    listen   (… jeen)
A gene that makes a protein called anaplastic lymphoma kinase (ALK), which may be involved in cell growth. Mutated (changed) forms of the ALK gene and protein have been found in some types of cancer, including neuroblastoma, non-small cell lung cancer, and anaplastic large cell lymphoma. These changes may increase the growth of cancer cells. Checking for changes in the ALK gene in tumor tissue may help to plan cancer treatment. Also called anaplastic lymphoma kinase gene.

alkali    listen   (AL-kuh-ly)
A chemical that can dissolve in water, combine with acids to form salts, and make acids less acidic. Alkalis have a bitter taste and turn certain dyes blue. Some alkalis can help the body work the way it should. An example of an alkali is sodium hydroxide.

alkalinity    listen   (AL-kuh-lih-nih-tee)
Refers to the amount of alkali. An alkali is a chemical that can dissolve in water, combine with acids to form salts, and make acids less acidic.

alkalinization    listen   (AL-kuh-LIH-nih-ZAY-shun)
A process that lowers the amount of acid in a solution. In medicine, an alkali, such as sodium bicarbonate, may be given to patients to lower high levels of acid in the blood or urine that can be caused by certain medicines or conditions.

alkaloid    listen   (AL-kuh-loyd)
A member of a large group of substances found in plants and in some fungi. Alkaloids contain nitrogen and can be made in the laboratory. Nicotine, caffeine, codeine, and vincristine are alkaloids. Some alkaloids, such as vincristine, are used to treat cancer.

Alkeran    listen   (al-KEH-run)
A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents. Also called melphalan.

alkylating agent    listen   (AL-kuh-LAY-ting AY-jent)
A type of drug that is used in the treatment of cancer. It interferes with the cell's DNA and inhibits cancer cell growth.

ALL      
An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow. Also called acute lymphoblastic leukemia and acute lymphocytic leukemia.

all-trans retinoic acid    listen   (all-tranz REH-tih-NOH-ik A-sid)
A nutrient that the body needs in small amounts to function and stay healthy. All-trans retinoic acid is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of all-trans retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). All-trans retinoic acid is being studied in the prevention and treatment of other types of cancer. Also called ATRA, retinoic acid, tretinoin, and vitamin A acid.

Allegra    listen   (uh-LEH-gruh)
A drug used to treat certain allergy symptoms. It blocks a chemical released during an allergic response that causes itching, sneezing, runny nose, wheezing, and watery eyes. It is a type of antihistamine. Also called fexofenadine.

allergen    listen   (A-ler-jen)
A substance that causes an allergic response. Examples include pollen, molds, and certain foods.

allergic response    listen   (uh-LER-jik reh-SPONTS)
A hypersensitive immune reaction to a substance that normally is harmless or would not cause an immune response in most people. An allergic response may cause harmful symptoms such as itching or inflammation or tissue injury.

allogeneic    listen   (A-loh-jeh-NAY-ik)
Taken from different individuals of the same species. Also called allogenic.

allogeneic bone marrow transplantation    listen   (A-loh-jeh-NAY-ik bone MAYR-oh tranz-plan-TAY-shun)
A procedure in which a person receives stem cells (cells from which all blood cells develop) from a genetically similar, but not identical, donor.

allogeneic stem cell transplantation    listen   (A-loh-jeh-NAY-ik stem sel tranz-plan-TAY-shun)
A procedure in which a person receives blood-forming stem cells (cells from which all blood cells develop) from a genetically similar, but not identical, donor. This is often a sister or brother, but could be an unrelated donor.

allogenic    listen   (A-loh-JEH-nik)
Taken from different individuals of the same species. Also called allogeneic.

allograft    listen   (A-loh-graft)
The transplant of an organ, tissue, or cells from one individual to another individual of the same species who is not an identical twin.

allopathic medicine    listen   (A-loh-PA-thik MEH-dih-sin)
A system in which medical doctors and other healthcare professionals (such as nurses, pharmacists, and therapists) treat symptoms and diseases using drugs, radiation, or surgery. Also called biomedicine, conventional medicine, mainstream medicine, orthodox medicine, and Western medicine.

allopurinol    listen   (a-loh-PYOOR-rih-nol)
A drug that lowers high levels of uric acid (a byproduct of metabolism) in the blood caused by some cancer treatments.

Allovectin-7    listen   (A-loh-VEK-tin ...)
A substance that is being studied as a gene therapy agent in the treatment of cancer. It increases the ability of the immune system to recognize cancer cells and kill them.

aloe-emodin    listen   (A-loh-EH-muh-din)
A substance found in certain plants, including aloe vera. It belongs to a family of compounds called anthraquinones, which have shown anti-inflammatory and anticancer effects.

alopecia    listen   (A-loh-PEE-shuh)
The lack or loss of hair from areas of the body where hair is usually found. Alopecia can be a side effect of some cancer treatments.

Aloxi    listen   (uh-LOK-see)
A drug used to prevent nausea and vomiting caused by chemotherapy. It is also used to prevent nausea and vomiting after surgery. Aloxi blocks the action of the chemical serotonin in the brain, which may help lessen nausea and vomiting. It is a type of serotonin receptor antagonist and a type of antiemetic. Also called palonosetron hydrochloride.

alpha emitter radiation therapy       (AL-fuh ee-MIH-ter RAY-dee-AY-shun THAYR-uh-pee)
Therapy that uses a radioactive substance that gives off a type of high-energy radiation called an alpha-particle to kill cancer cells. The radioactive substance is injected into a vein, travels through the blood, and collects in certain tissues in the body, such as areas of bone with cancer. This type of radiation may cause less damage to nearby healthy tissue. Alpha emitter radiation therapy is used to treat prostate cancer that has spread to the bone, and it is being studied in the treatment of other types of cancer.

alpha hydroxyl acid    listen   (AL-fuh hy-DROK-sil A-sid)
One of a group of substances that are found in several types of fruit and in milk. They are used in skin care products to reduce wrinkles and soften the skin. Examples of alpha hydroxyl acids are glycolic acid, lactic acid, and citric acid. Also called AHA and fruit acid.

alpha-adrenergic antagonist    listen   (AL-fuh-A-dreh-NER-jik an-TA-guh-nist)
A substance that relaxes muscle tissue in blood vessels and in the prostate gland, which improves the flow of urine and blood. Alpha-adrenergic antagonists are used to treat the symptoms of many conditions, such as benign prostatic hyperplasia (BPH), high blood pressure, and some blood circulation problems. Also called alpha-blocker.

alpha-blocker    listen   (AL-fuh-BLAH-ker)
A substance that relaxes muscle tissue in blood vessels and in the prostate gland, which improves the flow of urine and blood. Alpha-blockers are used to treat the symptoms of many conditions, such as benign prostatic hyperplasia (BPH), high blood pressure, and some blood circulation problems. Also called alpha-adrenergic antagonist.

alpha-fetoprotein    listen   (AL-fuh-FEE-toh-PROH-teen)
A protein normally produced by a fetus. Alpha-fetoprotein levels are usually undetectable in the blood of healthy adult men or women (who are not pregnant). An elevated level of alpha-fetoprotein suggests the presence of either a primary liver cancer or germ cell tumor. Also called AFP.

alpha-lipoic acid    listen   (AL-fuh-lih-POH-ik A-sid)
A substance that is being studied for its ability to protect normal cells from the side effects of chemotherapy and prevent peripheral neuropathy (numbness, tingling, burning, and weakness in the hands or feet). Alpha-lipoic acid is made by the body and can be found in foods such as organ meats, spinach, broccoli, peas, brussel sprouts, and rice bran. It can also be made in the laboratory. Alpha-lipoic acid is a type of antioxidant and chemoprotective agent.

alpha-tocopherol    listen   (AL-fuh-toh-KAH-feh-rol)
A nutrient that the body needs in small amounts to stay healthy and work the way it should. It is fat-soluble (can dissolve in fats and oils) and is found in seeds, nuts, leafy green vegetables, and vegetable oils. Alpha-tocopherol boosts the immune system and helps keep blood clots from forming. It also helps prevent cell damage caused by free radicals (highly reactive chemicals). Alpha-tocopherol is being studied in the prevention and treatment of some types of cancer. It is a type of antioxidant. Also called vitamin E.

alprazolam    listen   (al-PRAY-zoh-lam)
A drug used to treat anxiety disorders and panic attacks. It is being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine. Also called Xanax.

alprostadil    listen   (al-PROS-tuh-dil)
A drug that is used to treat impotence (inability to have an erection) and is being studied in the treatment of sexual problems in men who have had surgery for prostate cancer. It is a type of vasodilator. Also called PGE1 and prostaglandin E1.

ALTENS    listen  
A procedure in which mild electric currents are applied to certain acupuncture points (spots on the body where an acupuncture needle may be inserted to control pain and other symptoms) on the skin. It is being studied in the treatment of dry mouth caused by radiation therapy for cancer. Also called acupuncture-like transcutaneous electrical nerve stimulation.

Alteplase    listen   (AL-teh-plays)
A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent. Also called Activase, r-tPA, and recombinant tissue plasminogen activator.

alteration    listen   (all-teh-RAY-shun)
A change resulting in something that is different from the original.

alternative medicine    listen   (all-TER-nuh-tiv MEH-dih-sin)
Treatments that are used instead of standard treatments. Standard treatments are based on the results of scientific research and are currently accepted and widely used. Less research has been done for most types of alternative medicine. Alternative medicine may include special diets, megadose vitamins, herbal preparations, special teas, and magnet therapy. For example, a special diet may be used instead of anticancer drugs as a treatment for cancer.

altretamine    listen   (al-TREH-tuh-meen)
An anticancer drug that belongs to the family of drugs called alkylating agents.

alum    listen   (A-lum)
A chemical substance that contains aluminum sulfate and a second chemical, usually potassium sulfate. It is used to shrink tissues, to stop bleeding, and to boost the immune response to a vaccine.

aluminum    listen   (uh-LOO-mih-num)
A metallic element that is found combined with other elements in the earth’s crust. It is also found in small amounts in soil, water, and many foods. It is used in medicine and dentistry and in many products such as foil, cans, pots and pans, airplanes, siding, and roofs. High levels of aluminum in the body can be harmful.

ALVAC-CEA vaccine    listen   (… vak-SEEN)
A cancer vaccine made with a form of the canarypox virus that does not cause disease in people. It is being studied in the treatment of some kinds of cancer. The virus is changed in the laboratory to make a protein called carcinoembryonic antigen (CEA), which is a tumor marker. ALVAC-CEA vaccine may help the immune system find and kill cancer cells that make CEA.

alveolar rhabdomyosarcoma    listen   (al-VEE-oh-ler RAB-doh-MY-oh-sar-KOH-muh)
A soft tissue tumor that is most common in older children and teenagers. It begins in embryonic muscle cells (cells that develop into muscles in the body). It can occur at many places in the body, but usually occurs in the trunk, arms, or legs. Also called ARMS.

alveolar soft part sarcoma    listen   (al-VEE-oh-ler … sar-KOH-muh)
A soft tissue tumor that is most common in older children and teenagers. It begins in the soft supporting tissue that connects and surrounds the organs and other tissues. Alveolar soft part sarcoma usually occurs in the legs, but can also occur in the arms, hands, head, or neck. It can cause the growth of new blood vessels that help the tumor grow and spread. Also called ASPS.

alveoli    listen   (al-VEE-oh-ly)
Tiny air sacs at the end of the bronchioles (tiny branches of air tubes) in the lungs. The alveoli are where the lungs and the bloodstream exchange carbon dioxide and oxygen. Carbon dioxide in the blood passes into the lungs through the alveoli. Oxygen in the lungs passes through the alveoli into the blood.

alvocidib    listen   (al-VOH-sih-dib)
A substance being studied in the treatment of several types of cancer. It stops cells from dividing and may kill cancer cells. It is a type of cyclin-dependent kinase (CDK) inhibitor. Also called flavopiridol and HMR 1275.

Alzheimer dementia    listen   (ALTS-hy-mer deh-MEN-shuh)
A brain disorder that usually starts in late middle age or old age and gets worse over time. Symptoms include loss of memory, confusion, difficulty thinking, and changes in language, behavior, and personality. Also called Alzheimer disease.

Alzheimer disease    listen   (ALTS-hy-mer dih-ZEEZ)
A brain disorder that usually starts in late middle age or old age and gets worse over time. Symptoms include loss of memory, confusion, difficulty thinking, and changes in language, behavior, and personality. Also called Alzheimer dementia.

Amanita phalloides    listen   (a-muh-NY-tuh fuh-LOY-deez)
A type of poisonous mushroom that has harmful effects on the kidneys and liver. It is responsible for most fatal cases of mushroom poisoning. Also called death cap.

amantadine hydrochloride    listen   (uh-MAN-tuh-deen HY-droh-KLOR-ide)
A drug used to treat infections caused by the influenza A virus. It blocks the ability of the virus to infect cells and to make more virus particles. It is also used to treat the symptoms of Parkinson disease. Amantidine hydrochloride is a type of antiviral agent.

amatuximab    listen   (A-muh-TUK-sih-mab)
A substance being studied in the treatment of mesothelioma. Amatuximab binds to a protein called mesothelin, which is found on some cancer cells. Amatuximab may help the immune system kill cancer cells. It is a type of monoclonal antibody. Also called anti-mesothelin monoclonal antibody MORAb-009 and MORAb-009.

Ambien    listen   (AM-bee-un)
A drug used to treat insomnia (inability to sleep), and anxiety. It is a type of imidazopyridine (sedative hypnotic). Also called zolpidem.

AMD      
A condition in which there is a slow breakdown of cells in the center of the retina (the light-sensitive layers of nerve tissue at the back of the eye). This blocks vision in the center of the eye and can cause problems with activities such as reading and driving. AMD is most often seen in people who are over the age of 50. Also called age-related macular degeneration, ARMD, and macular degeneration.

AMD 3100      
A drug used before autologous stem cell transplantation in patients with non-Hodgkin lymphoma or multiple myeloma. AMD 3100 is given together with granulocyte-colony stimulating factor (G-CSF) to help move stem cells from the bone marrow to the blood. The stem cells can then be collected, stored, and given back to the patient. AMD 3100 is a type of chemokine receptor antagonist. Also called Mozobil and plerixafor.

amelanotic melanoma    listen   (AY-meh-luh-NAH-tik MEH-luh-NOH-muh)
A type of skin cancer in which the cells do not make the pigment melanin. Skin lesions are often irregular and may be pink, red, or have light brown, tan, or gray at the edges.

amethopterin    listen   (A-meh-THOP-teh-rin)
A drug used to treat some types of cancer, rheumatoid arthritis, and severe skin conditions, such as psoriasis. Amethopterin stops cells from making DNA and may kill cancer cells. It is a type of antimetabolite. Also called methotrexate, MTX, and Rheumatrex.

Amevive    listen   (A-meh-veev)
A drug that is used to treat certain skin conditions and is being studied in the treatment of cutaneous (skin-related) T-cell cancer and T-cell non-Hodgkin lymphoma. Amevive is made by combining part of an antibody with a protein that blocks the growth some types of T cells. It is a type of fusion protein and a type of immunosuppressant. Also called alefacept.

AMG 102      
A substance being studied in the treatment of cancer. It binds to a protein called hepatocyte growth factor (HGF), which may cause cancer cells to grow. Blocking this may cause cancer cells to die. AMG 102 is a type of monoclonal antibody. Also called anti-HGF monoclonal antibody AMG 102.

AMG 162      
A drug used to prevent or treat certain bone problems. Under the brand name Xgeva, it is used to prevent broken bones and other bone problems caused by solid tumors that have spread to bone. It is also used in certain patients to treat giant cell tumor of the bone that cannot be removed by surgery. Under the brand name Prolia, it is used to treat osteoporosis (a decrease in bone mass and density) in postmenopausal women who have a high risk of breaking bones. AMG 162 is also being studied in the treatment of other conditions and types of cancer. It binds to a protein called RANKL, which keeps RANKL from binding to another protein called RANK on the surface of certain bone cells, including bone cancer cells. This may help keep bone from breaking down and cancer cells from growing. AMG 162 is a type of monoclonal antibody. Also called denosumab, Prolia, and Xgeva.

AMG 531      
A drug used to treat patients with immune thrombocytopenic purpura (ITP) who do not get better with other forms of treatment. In ITP, platelets (cells that cause blood clots to form) are destroyed by the immune system. AMG 531 is being studied as a way to treat low platelet counts caused by chemotherapy. It binds to the thrombopoietin receptor and causes the bone marrow to make more platelets. AMG 531 is also being studied in the treatment of myelodysplastic syndromes (a group of diseases in which the bone marrow does not make enough healthy blood cells). It is a type of thrombopoietin agonist. Also called Nplate and romiplostim.

AMG 706      
A substance that is being studied in the treatment of some types of cancer. It belongs to the families of drugs called angiogenesis inhibitors and protein kinase inhibitors.

amifostine    listen   (A-mih-FOS-teen)
A drug used as a chemoprotective drug to control some of the side effects of chemotherapy and radiation therapy.

amikacin    listen   (A-mih-KAY-sin)
An antibiotic drug used to treat infection. It belongs to the family of drugs called aminoglycoside antibiotics.

amino acid    listen   (uh-MEE-noh A-sid)
One of several molecules that join together to form proteins. There are 20 common amino acids found in proteins.

amino acid sequence    listen   (uh-MEE-noh A-sid SEE-kwents)
The arrangement of amino acids in a protein. Proteins can be made from 20 different kinds of amino acids, and the structure and function of each protein are determined by the kinds of amino acids used to make it and how they are arranged.

aminobenzoic acid    listen   (uh-MEE-noh-ben-ZOH-ik-A-sid)
A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Bacteria that live in the intestines need aminobenzoic acid to survive. Aminobenzoic acid is found in grains and foods from animals. It is being studied as a radiosensitizer (a substance that makes tumor cells more sensitive to radiation therapy) and in the treatment of certain skin disorders. Also called PABA and para-aminobenzoic acid.

aminocamptothecin    listen   (uh-MEE-noh-KAMP-toh-THEH-kin)
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.

aminoglutethimide    listen   (uh-MEE-noh-gloo-TETH-ih-mide)
An anticancer drug that belongs to the family of drugs called nonsteroidal aromatase inhibitors. Aminoglutethimide is used to decrease the production of sex hormones (estrogen in women or testosterone in men) and suppress the growth of tumors that need sex hormones to grow.

aminoglycoside antibiotic    listen   (uh-MEE-noh-GLY-koh-side AN-tee-by-AH-tik)
A substance that works against many types of bacteria and includes streptomycin, gentamicin, and neomycin. An aminoglycoside antibiotic is used to treat bacterial infections.

aminolevulinic acid    listen   (uh-MEE-noh-LEH-vyoo-LIH-nik A-sid)
The active ingredient in a drug used to treat actinic keratosis (a skin condition that may become cancer). The drug is also being studied in the treatment of squamous cell and basal cell skin cancers and other types of cancer. When aminolevulinic acid is taken up by cells, including cancer cells, and then exposed to certain types of light, it becomes active and kills the cells. It is a type of photosensitizing agent.

aminolevulinic acid hydrochloride    listen   (uh-MEE-noh-LEH-vyoo-LIH-nik A-sid HY-droh-KLOR-ide)
A drug used to treat actinic keratosis (a skin condition that may become cancer). The drug is also being studied in the treatment of squamous cell and basal cell skin cancers and other types of cancer. When aminolevulinic acid hydrochloride is taken up by cells, including cancer cells, and then exposed to certain types of light, it becomes active and kills the cells. It is a type of photosensitizing agent. Also called Levulan and Levulan Kerastick.

aminopterin    listen   (a-mih-NOP-teh-rin)
An anticancer drug that belongs to the family of drugs called antimetabolites.

amiodarone hydrochloride    listen   (A-mee-OH-duh-rone HY-droh-KLOR-ide)
A drug used to treat certain types of abnormal heart rhythms that have not gotten better with other drugs. Amiodarone hydrochloride affects the electrical activity of the heart. It is a type of antiarrhythmic agent. Also called Corderone.

amitriptyline    listen   (A-mih-TRIP-tih-LEEN)
A drug that is used to treat depression and may be given to treat anxiety, sleep disorders, and pain. It is also being studied in an oral or gel form in the treatment of nerve pain caused by chemotherapy. Amitriptyline is a type of tricyclic antidepressant. Also called amitriptyline hydrochloride.

amitriptyline hydrochloride    listen   (A-mih-TRIP-tih-LEEN HY-droh-KLOR-ide)
A drug that is used to treat depression and may be given to treat anxiety, sleep disorders, and pain. It is also being studied in an oral or gel form in the treatment of nerve pain caused by chemotherapy. Amitriptyline hydrochloride is a type of tricyclic antidepressant. Also called amitriptyline.

AML      
An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. Also called acute myeloblastic leukemia, acute myelogenous leukemia, acute myeloid leukemia, acute nonlymphocytic leukemia, and ANLL.

ammonia    listen   (uh-MOH-nyuh)
A gas made of nitrogen and hydrogen. It has a strong odor and can irritate the skin, eyes, nose, throat, and lungs. Ammonia is made by bacteria and decaying plants and animals and is found in water, soil, and air. Ammonia is also made by the body when proteins break down. In the laboratory, ammonia can be changed to a liquid and used in medicines, fertilizers, household cleaning liquids, and other products. It is also added to cigarettes to increase the effect of nicotine on the body.

ammonium tetrathiomolybdate    listen   (uh-MOH-nee-um TEH-truh-THY-oh-muh-LIB-dayt)
A substance being studied in the treatment of many types of cancer. Ammonium tetrathiomolybdate removes extra copper from the body. Removing the copper may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. Ammonium tetrathiomolybdate is a type of chelating agent and a type of antiangiogenesis agent.

amonafide    listen   (ay-MOH-nah-fide)
A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.

amoxicillin    listen   (uh-MOK-sih-SIH-lin)
A drug used to treat some bacterial infections. Amoxicillin is a form of penicillin that is made in the laboratory. It kills certain types of bacteria. It is a type of antibiotic.

amoxicillin-clavulanate potassium    listen   (uh-MOK-sih-SIH-lin-kla-vyoo-LA-nayt puh-TA-see-um)
A drug used to treat bacterial infections. Adding the chemical clavulanate potassium to the antibiotic amoxicillin increases the amount of time the antibiotic stays active in the body. Amoxicillin-clavulanate potassium is a type of combination antibiotic. Also called Augmentin.

amphotericin B    listen   (AM-fuh-TAYR-ih-sin ...)
A drug used in the treatment of infections caused by fungi. It is a type of antifungal.

Amplimexon    listen   (AM-plih-MEK-son)
A substance that is being studied in the treatment of some types of cancer, including pancreatic, lung, breast, prostate, melanoma, and multiple myeloma. It belongs to the family of drugs called cyanoaziridine derivatives. Also called imexon.

ampulla    listen   (am-PUH-luh)
A sac-like enlargement of a canal or duct.

ampulla of Vater    listen   (am-PUH-luh ... VAH-ter)
An enlargement of the ducts from the liver and pancreas at the point where they enter the small intestine.

ampulla of Vater cancer    listen   (am-PUH-luh ... VAH-ter KAN-ser)
Cancer that forms in the ampulla of Vater (an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine). Symptoms include jaundice, abdominal pain, nausea, vomiting, and weight loss. Also called ampullary cancer.

ampullary cancer    listen   (AM-puh-LAYR-ee KAN-ser)
Cancer that forms in the ampulla of Vater (an enlargement of the ducts from the liver and pancreas where they join and enter the small intestine). Symptoms include jaundice, abdominal pain, nausea, vomiting, and weight loss. Also called ampulla of Vater cancer.

amputation    listen   (am-pyoo-TAY-shun)
The removal by surgery of a limb (arm or leg) or other body part because of injury or disease, such as diabetes or cancer.

amrubicin    listen   (am-ROO-bih-sin)
A substance being studied in the treatment of lung cancer. It is a type of anthracycline analog.

amsacrine    listen   (AM-suh-kreen)
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.

amuvatinib    listen   (AM-yoo-VA-tih-nib)
A substance being studied in the treatment of some types of cancer. It may block certain proteins involved in cancer cell growth and DNA repair. Blocking these proteins may make cancer cells more sensitive to anticancer drugs and radiation therapy. Amuvatinib is a type of tyrosine kinase inhibitor. Also called MP470.

amygdalin    listen   (uh-MIG-duh-lin)
A substance found in the pits of many fruits such as apricots and papayas, and in other foods. It has been tried in some countries as a treatment for cancer, but it has not been shown to work in clinical studies. Amygdalin is not approved for use in the United States. Also called laetrile.

amylase    listen   (A-mih-lays)
An enzyme that helps the body digest starches.

amyloidosis    listen   (A-muh-loy-DOH-sis)
A group of diseases in which protein builds up in certain organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause), secondary (caused by another disease, including some types of cancer, such as multiple myeloma), or hereditary (passed down from parents to children). Many organs are affected by amyloidosis. The organs affected may depend on whether the amyloidosis is the primary, secondary, or hereditary form.

anabolic steroid    listen   (A-nuh-BAH-lik STAYR-oyd)
A type of steroid that is used in medicine to repair body tissues and to increase appetite and the growth of muscles. Anabolic steroids are made in the laboratory from testosterone (a male hormone).

anagrelide    listen   (an-AG-re-lide)
A drug that is used to decrease the number of platelets in the blood in order to prevent blood clotting.

anakinra    listen   (A-nuh-KIN-ruh)
A substance that is used to treat rheumatoid arthritis, and is being studied in the treatment of cancer. Anakinra blocks the action of interleukin 1 (IL-1). It is a type of interleukin receptor antagonist. Also called Kinaret.

anal    listen   (AY-nul)
Having to do with the anus. The anus is the opening of the rectum (last part of the large intestine) to the outside of the body.

anal cancer    listen   (AY-nul KAN-ser)
Cancer that forms in tissues of the anus. The anus is the opening of the rectum (last part of the large intestine) to the outside of the body.

anal Pap smear    listen   (AY-nul … smeer)
A procedure in which cells are scraped from the lining of the anus (the opening of the rectum to the outside of the body) and looked at under a microscope. It is used to find cancer and changes in cells that may lead to cancer. An anal Pap smear can also show conditions that are not cancer, such as infection or inflammation. Also called anal Pap test.

anal Pap test    listen   (AY-nul …)
A procedure in which cells are scraped from the lining of the anus (the opening of the rectum to the outside of the body) and looked at under a microscope. It is used to find cancer and changes in cells that may lead to cancer. An anal Pap test can also show conditions that are not cancer, such as infection or inflammation. Also called anal Pap smear.

analgesia    listen   (A-nul-JEE-zhee-uh)
Pain relief.

analgesic    listen   (A-nul-JEE-zik)
A drug that reduces pain. Analgesics include aspirin, acetaminophen, and ibuprofen.

analog    listen   (A-nuh-log)
In chemistry, a substance that is similar, but not identical, to another.

analysis    listen   (uh-NA-lih-sis)
A process in which anything complex is separated into simple or less complex parts.

anaphylactic shock    listen   (A-nuh-fih-LAK-tik shok)
A severe and sometimes life-threatening immune system reaction to an antigen that a person has been previously exposed to. The reaction may include itchy skin, edema, collapsed blood vessels, fainting, difficulty in breathing, and death.

anaplastic    listen   (A-nuh-PLAS-tik)
A term used to describe cancer cells that divide rapidly and have little or no resemblance to normal cells.

anaplastic large cell lymphoma    listen   (A-nuh-PLAS-tik larj sel lim-FOH-muh)
An aggressive (fast-growing) type of non-Hodgkin lymphoma that is usually of the T-cell type. The cancer cells express a marker called CD30 or Ki-1 on the surface, and may appear in the lymph nodes, skin, bones, soft tissues, lungs, or liver. Also called ALCL.

anaplastic lymphoma kinase gene    listen   (A-nuh-PLAS-tik lim-FOH-muh KY-nays jeen)
A gene that makes a protein called anaplastic lymphoma kinase (ALK), which may be involved in cell growth. Mutated (changed) forms of the ALK gene and protein have been found in some types of cancer, including neuroblastoma, non-small cell lung cancer, and anaplastic large cell lymphoma. These changes may increase the growth of cancer cells. Checking for changes in the anaplastic lymphoma kinase gene in tumor tissue may help to plan cancer treatment. Also called ALK gene.

anaplastic lymphoma receptor tyrosine kinase    listen   (A-nuh-PLAS-tik lim-FOH-muh reh-SEP-ter TY-ruh-seen KY-nays)
A protein that is found on the outside of cells that sends signals into the cells. These signals help control cell growth and division. It is made by the anaplastic lymphoma kinase (ALK) gene, which may be changed in some types of cancer, such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. These changes in the ALK gene can cause the cancer cells to grow and spread.

anaplastic thyroid cancer    listen   (A-nuh-PLAS-tik THY-royd KAN-ser)
A rare, aggressive type of thyroid cancer in which the malignant (cancer) cells look very different from normal thyroid cells.

anastomosis    listen   (uh-NAS-toh-MOH-sis)
A procedure to connect healthy sections of tubular structures in the body after the diseased portion has been surgically removed.

anastrozole    listen   (an-AS-troh-zole)
An anticancer drug that is used to decrease estrogen production and suppress the growth of tumors that need estrogen to grow. It is a type of nonsteroidal aromatase inhibitor.

anatomic    listen   (A-nuh-TAH-mik)
Having to do with anatomy (the study of the structure of a plant or animal).

anatomist    listen   (uh-NA-tuh-mist)
A person who specializes in anatomy (the study of the structures of animals or plants).

anatomy    listen   (uh-NA-toh-mee)
The study of the structure of a plant or animal.

ANC      
A measure of the number of neutrophils in the blood. Neutrophils are a type of white blood cell. They help the body fight infection. An ANC may be used to check for infection, inflammation, leukemia, and other conditions. The lower a person's ANC is, the higher the risk is of getting an infection. Having an ANC of less than 500 means there is a high risk of getting an infection. Cancer treatment, such as chemotherapy, may reduce the ANC. Also called absolute neutrophil count.

ancestim    listen   (an-SES-tim)
A substance that causes blood stem cells (cells from which other types of cells develop) to change into different types of blood cells and increases the number and actions of these cells in the blood. It is being studied in the treatment of myelodysplasia. Ancestim is a type of recombinant stem cell growth factor. Also called r-metHuSCF, recombinant human methionyl stem cell factor, and Stemgen.

ancillary test    listen   (AN-sih-LAYR-ree …)
In a clinical trial, a medical test on a patient that is not a part of the original study design.

androblastoma    listen   (AN-droh-blas-TOH-muh)
A rare type of ovarian tumor in which the tumor cells secrete a male sex hormone. This may cause virilization (the appearance of male physical characteristics in females). Also called arrhenoblastoma and Sertoli-Leydig cell tumor of the ovary.

androgen    listen   (AN-droh-jen)
A type of hormone that promotes the development and maintenance of male sex characteristics.

androgen ablation    listen   (AN-droh-jen a-BLAY-shun)
Treatment to suppress or block the production or action of male hormones. This is done by having the testicles removed, by taking female sex hormones, or by taking drugs called antiandrogens. Also called androgen deprivation and androgen suppression.

androgen deprivation    listen   (AN-droh-jen DEH-prih-VAY-shun)
Treatment to suppress or block the production or action of male hormones. This is done by having the testicles removed, by taking female sex hormones, or by taking drugs called antiandrogens. Also called androgen ablation and androgen suppression.

androgen receptor    listen   (AN-droh-jen reh-SEP-ter)
A protein that binds male hormones called androgens. Androgen receptors are found inside the cells of male reproductive tissue, some other types of tissue, and some cancer cells. In prostate cancer, androgens bind to androgen receptors inside the cancer cells, which causes the cancer cells to grow. Also called AR.

androgen receptor positive    listen   (AN-droh-jen reh-SEP-ter PAH-zih-tiv)
Describes cells that have a protein that binds to androgens (male hormones). Cancer cells that are androgen receptor positive may need androgens to grow. These cells may stop growing or die when they are treated with substances that block the binding and actions of androgen hormones. Also called AR+.

androgen suppression    listen   (AN-droh-jen suh-PREH-shun)
Treatment to suppress or block the production or action of male hormones. This is done by having the testicles removed, by taking female sex hormones, or by taking drugs called antiandrogens. Also called androgen ablation and androgen deprivation.

androgen-independent    listen   (AN-droh-jen...)
Describes the ability of tumor cells to grow in the absence of androgens (hormones that promote the development and maintenance of male sex characteristics). Many early prostate cancers require androgens for growth, but advanced prostate cancers are often androgen-independent.

androstanolone    listen   (AN-droh-STAN-uh-lone)
A hormone made from testosterone in the prostate, testes, and certain other tissues. It is needed to develop and maintain male sex characteristics, such as facial hair, deep voice, and muscle growth. High amounts of androstanolone may increase the growth of prostate cancer and make it harder to treat. Also called DHT and dihydrotestosterone.

anecdotal report    listen   (A-nek-DOH-tul reh-PORT)
An incomplete description of the medical and treatment history of one or more patients. Anecdotal reports may be published in places other than peer-reviewed, scientific journals.

anemia    listen   (uh-NEE-mee-uh)
A condition in which the number of red blood cells is below normal.

anesthesia    listen   (A-nes-THEE-zhuh)
A loss of feeling or awareness caused by drugs or other substances. Anesthesia keeps patients from feeling pain during surgery or other procedures. Local anesthesia is a loss of feeling in one small area of the body. Regional anesthesia is a loss of feeling in a part of the body, such as an arm or leg. General anesthesia is a loss of feeling and a complete loss of awareness that feels like a very deep sleep.

anesthesiologist    listen   (A-nes-THEE-zee-AH-loh-jist)
A doctor who specializes in giving drugs or other agents to prevent or relieve pain during surgery or other procedures being done in the hospital.

anesthetic    listen   (A-nes-THEH-tik)
A drug or other substance that causes a loss of feeling or awareness. Local anesthetics cause a loss of feeling in one small area of the body. Regional anesthetics cause a loss of feeling in a part of the body, such as an arm or leg. General anesthetics cause a loss of feeling and a complete loss of awareness that feels like a very deep sleep.

anetholtrithione    listen   (A-neh-thol-try-THY-one)
A substance that is being studied in the treatment of cancer.

angelica root    listen   (an-JEH-lih-kuh root)
The root of any of a group of herbs called Angelica. It has been used in some cultures to treat certain medical problems, including gastrointestinal problems such as loss of appetite, feelings of fullness, and gas.

Angiocept    listen   (AN-jee-oh-sept)
A substance being studied in the treatment of cancer. Angiocept may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor and a type of antiangiogenesis agent. Also called CT-322 and VEGFR-2 inhibitor CT-322.

angiogenesis    listen   (AN-jee-oh-JEH-neh-sis)
Blood vessel formation. Tumor angiogenesis is the growth of new blood vessels that tumors need to grow. This process is caused by the release of chemicals by the tumor and by host cells near the tumor.

angiogenesis inhibitor    listen   (AN-jee-oh-JEH-neh-sis in-HIH-bih-ter)
A drug or substance that keeps new blood vessels from forming. In cancer treatment, angiogenesis inhibitors may prevent the growth of new blood vessels that tumors need to grow. Also called antiangiogenesis agent.

angiogram    listen   (AN-jee-oh-gram)
An x-ray or computer image (CT scan or MRI) of the blood vessels and blood flow in the body. A dye may be injected through a catheter (small tube) into an artery or vein to make the blood vessels easier to see. An angiogram may be used to check for an aneurysm (a bulge in a blood vessel wall), blockages in arteries, blood clots, or other problems, such as a tumor.

angiography    listen   (an-jee-AH-gruh-fee)
A procedure to x-ray blood vessels. The blood vessels can be seen because of an injection of a dye that shows up in the x-ray.

angioimmunoblastic T-cell lymphoma    listen   (AN-jee-oh-IH-myoo-noh-BLAS-tik T-sel lim-FOH-muh)
An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma marked by enlarged lymph nodes and hypergammaglobulinemia (increased antibodies in the blood). Other symptoms may include a skin rash, fever, weight loss, or night sweats.

angiomyolipoma    listen   (AN-jee-oh-MY-oh-lih-POH-muh)
A benign (noncancer) tumor of fat and muscle tissue that usually is found in the kidney. Angiomyolipomas rarely cause symptoms, but may bleed or grow large enough to be painful or cause kidney failure. They are common in patients with tuberous sclerosis (a genetic disorder in which benign tumors grow in the kidneys, brain, eyes, heart, lungs, and skin, causing seizures, mental problems, and skin lesions).

angioplasty    listen   (AN-jee-oh-PLAS-tee)
A procedure to enlarge the opening in a blood vessel that has become narrowed or blocked by plaque (a buildup of fat and cholesterol on the inner wall of the blood vessel). Examples of angioplasty are balloon angioplasty and laser angioplasty.

angiosarcoma    listen   (AN-jee-oh-sar-KOH-muh)
A type of cancer that begins in the cells that line blood vessels or lymph vessels. Cancer that begins in blood vessels is called hemangiosarcoma. Cancer that begins in lymph vessels is called lymphangiosarcoma.

angiostatin    listen   (AN-jee-oh-STA-tin)
A protein normally made by the body. It can also be made in the laboratory, and is being studied in the treatment of cancer. Angiostatin may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.

angiotensin-converting enzyme inhibitor    listen   (AN-jee-oh-TEN-sin-kun-VER-ting EN-zime in-HIH-bih-ter)
A drug that is used to lower blood pressure. An angiotensin-converting enzyme inhibitor is a type of antihypertensive agent. Also called ACE inhibitor.

Angiozyme    listen   (AN-jee-oh-zime)
A substance being studied in the treatment of cancer. Angiozyme is a special type of RNA made in the laboratory. It stops a protein called vascular endothelial growth factor receptor (VEGFR) from being made. This may prevent the growth of new blood vessels that tumors need to grow. It is a type of angiogenesis inhibitor and a type of ribozyme. Also called RPI.4610.

anhydrovinblastine    listen   (an-HY-droh-vin-BLAS-teen)
An anticancer drug that belongs to the family of drugs called mitotic inhibitors.

anidulafungin    listen   (uh-NIH-dyoo-luh-FUN-jin)
A drug that is used to treat infections caused by fungi. It belongs to the family of drugs called antifungals.

animal model    listen   (A-nih-mul MAH-dul)
An animal with a disease either the same as or like a disease in humans. Animal models are used to study the development and progression of diseases and to test new treatments before they are given to humans. Animals with transplanted human cancers or other tissues are called xenograft models.

animal study    listen   (A-nih-mul STUH-dee)
A laboratory experiment using animals to study the development and progression of diseases. Animal studies also test how safe and effective new treatments are before they are tested in people.

animal-assisted therapy    listen   (A-nih-mul-uh-SIS-ted THAYR-uh-pee)
A type of therapy that uses dogs or other pets to improve the physical and mental health of patients with certain acute or chronic diseases. It is being studied as a way to relieve distress in cancer patients undergoing treatment for pain. Also called pet-facilitated therapy.

aniridia    listen   (A-nih-RIH-dee-uh)
A disorder in which a person is born without part or all of the iris (colored tissue at the front of the eyeball). Aniridia usually affects both eyes and causes other eye problems, including being sensitive to light and loss of vision.

ANLL      
An aggressive (fast-growing) disease in which too many myeloblasts (immature white blood cells that are not lymphoblasts) are found in the bone marrow and blood. Also called acute myeloblastic leukemia, acute myelogenous leukemia, acute myeloid leukemia, acute nonlymphocytic leukemia, and AML.

annamycin    listen   (A-nuh-MY-sin)
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anthracycline antibiotics.

anorexia    listen   (a-nuh-REK-see-uh)
An abnormal loss of the appetite for food. Anorexia can be caused by cancer, AIDS, a mental disorder (i.e., anorexia nervosa), or other diseases.

anorexia nervosa    listen   (a-nuh-REK-see-uh ner-VOH-suh)
An eating disorder marked by an intense fear of gaining weight, a refusal to maintain a healthy weight, and a distorted body image. People with anorexia nervosa have an abnormal loss of appetite for food, try to avoid eating, and eat as little as possible.

ANS      
The part of the nervous system that controls muscles of internal organs (such as the heart, blood vessels, lungs, stomach, and intestines) and glands (such as salivary glands and sweat glands). One part of the ANS helps the body rest, relax, and digest food and another part helps a person fight or take flight in an emergency. Also called autonomic nervous system and involuntary nervous system.

ansamycin    listen   (AN-suh-MY-sin)
An anticancer drug that belongs to the family of drugs called antineoplastic antibiotics.

antagonist    listen   (an-TA-guh-nist)
In medicine, a substance that stops the action or effect of another substance. For example, a drug that blocks the stimulating effect of estrogen on a tumor cell is called an estrogen receptor antagonist.

antenatal    listen   (AN-tee-NAY-tul)
Having to do with the time a female is pregnant, before birth occurs. Also called prenatal.

anterior    listen   (an-TEER-ee-er)
In human anatomy, has to do with the front of a structure, or a structure found toward the front of the body.

anterior mediastinotomy    listen   (an-TEER-ee-er MEE-dee-A-stih-NAH-toh-mee)
A procedure in which a tube is inserted into the chest to view the tissues and organs in the area between the lungs and between the breastbone and heart. The tube is inserted through an incision next to the breastbone. This procedure is usually used to get a tissue sample from the lymph nodes on the left side of the chest. Also called Chamberlain procedure.

anterior mediastinum    listen   (an-TEER-ee-er MEE-dee-uh-STY-num)
The area in the front part of the chest between the lungs. Also called prevascular space.

anterior pelvic exenteration    listen   (an-TEER-ee-er PEL-vik eg-ZEN-teh-RAY-shun)
Surgery to remove the urethra, lower part of the ureters, uterus, cervix, vagina, and bladder.

anterior urethral cancer    listen   (an-TEER-ee-er yoo-REE-thrul KAN-ser)
A disease in which malignant (cancer) cells are found in the part of the urethra (the tube through which urine leaves the body) that is closest to the outside of the body.

anthracenedione    listen   (AN-thruh-seen-DY-one)
An anticancer drug that belongs to the family of drugs called anticancer antibiotics.

anthracycline    listen   (AN-thruh-SY-klin)
A type of antibiotic that comes from certain types of Streptomyces bacteria. Anthracyclines are used to treat many types of cancer. Anthracyclines damage the DNA in cancer cells, causing them to die. Daunorubicin, doxorubicin, and epirubicin are anthracyclines.

anthraquinone    listen   (AN-thruh-kwih-NONE)
A type of anticancer drug.

anti-CCR2 monoclonal antibody MLN1202    listen   (AN-tee … MAH-noh-KLOH-nul AN-tee-BAH-dee …)
A substance being studied as a treatment for atherosclerosis (a build-up of fat in the arteries). It is also being studied in the treatment of cancers that spread to the bone. Anti-CCR2 monoclonal antibody MLN1202 binds to a protein called CCR2, which is found on the surface of certain bone cells, white blood cells, and cancer cells. Anti-CCR2 monoclonal antibody MLN1202 blocks the action of a substance that is involved in keeping healthy bone mass. It may help keep the cancer cells from spreading to and growing in the bone. It is a type of monoclonal antibody. Also called MLN1202.

anti-CD19 immunotoxin    listen   (AN-tee … IH-myoo-noh-TOK-sin)
A monoclonal antibody linked to a toxic substance. It is being studied in the treatment of some types of B-cell cancer. Anti-CD19 immunotoxin is made in the laboratory. It binds to CD19, a protein on the surface of normal B cells and B-cell tumors, and kills the cells.

anti-CD22 immunotoxin    listen   (AN-tee … IH-myoo-noh-TOK-sin)
A monoclonal antibody linked to a toxic substance. It is being studied in the treatment of some types of B-cell cancer. Anti-CD22 immunotoxin is made in the laboratory. It binds to CD22, a protein on the surface of normal B cells and B-cell tumors, and kills the cells.

anti-CD22 immunotoxin CAT-8015    listen   (AN-tee … IH-myoo-noh-TOK-sin …)
A monoclonal antibody linked to a toxic substance. It is being studied in the treatment of some types of B-cell cancer. Anti-CD22 immunotoxin CAT-8015 is made in the laboratory. It binds to CD22, a protein on the surface of normal B cells and B-cell tumors, and kills the cells. Also called CAT-8015.

anti-CD45 monoclonal antibody    listen   (AN-tee … MAH-noh-KLOH-nul AN-tee-BAH-dee)
A substance being studied in the treatment of some types of leukemia and lymphoma. Anti-CD45 monoclonal antibody binds to a protein called CD45, which is found on most types of blood cells and some types of leukemia and lymphoma cells. Anti-CD45 monoclonal antibody may help the immune system kill cancer cells. It is a type of monoclonal antibody.

anti-CEA antibody    listen   (AN-tee ... AN-tee-BAH-dee)
An antibody against carcinoembryonic antigen (CEA), a protein present on certain types of cancer cells.

anti-EpCAM-Pseudomonas-exotoxin fusion protein    listen   (AN-tee ... SOO-doh-MOH-nus-EK-soh-TOK-sin FYOO-zhun PROH-teen)
A substance being studied in the treatment of certain types of head and neck cancer. Anti-EpCAM-Pseudomonas-exotoxin fusion protein is made by linking a monoclonal antibody fragment to a toxic protein that may kill cancer cells. It binds to EpCAM (a protein on the surface of epithelial cells and some types of cancer cells). Also called Proxinium and VB4-845.

anti-HGF monoclonal antibody AMG 102    listen   (AN-tee … MAH-noh-KLOH-nul AN-tee-BAH-dee ...)
A substance being studied in the treatment of cancer. It binds to a protein called hepatocyte growth factor (HGF), which may cause cancer cells to grow. Blocking this may cause cancer cells to die. Anti-HGF monoclonal antibody AMG 102 is a type of monoclonal antibody. Also called AMG 102.

anti-idiotype vaccine    listen   (AN-tee-IH-dee-oh-TIPE vak-SEEN)
A vaccine made of antibodies that see other antibodies as the antigen and bind to it. Anti-idiotype vaccines can stimulate the body to produce antibodies against tumor cells.

anti-IGF1R recombinant monoclonal antibody MK-0646    listen   (AN-tee … ree-KOM-bih-nunt MAH-noh-KLOH-nul AN-tee-BAH-dee …)
A substance being studied in the treatment of many types of cancer. Anti-IGF1R recombinant monoclonal antibody MK-0646 binds to a protein called insulin-like growth factor receptor (IGFR) on the surface of cells. This may prevent the cells from growing when IGF is present. It may also kill cancer cells. Anti-IGF1R recombinant monoclonal antibody MK-0646 is a type of monoclonal antibody. Also called MK-0646.

anti-IL-6 chimeric monoclonal antibody    listen   (AN-tee ... ky-MEER-ik MAH-noh-KLOH-nul AN-tee-BAH-dee)
A drug used to treat a rare condition called Castleman disease in patients who do not have HIV or human herpesvirus 8. It is also being studied in the treatment of multiple myeloma. Anti-IL-6 chimeric monoclonal antibody binds to a protein called interleukin-6 (IL-6), which is made by some white blood cells and other cells in the body. Anti-IL-6 chimeric monoclonal antibody may help reduce inflammation and stop the growth of cancer cells or abnormal blood cells. It is a type of monoclonal antibody. Also called cCLB8, CNTO 328, siltuximab, and Sylvant.

anti-inflammatory    listen   (AN-tee-in-FLA-muh-TOR-ee)
Having to do with reducing inflammation.

anti-mesothelin monoclonal antibody MORAb-009    listen   (AN-tee-MEH-zoh-THEE-lin MAH-noh-KLOH-nul AN-tee-BAH-dee…)
A substance being studied in the treatment of mesothelioma. Anti-mesothelin monoclonal antibody MORAb-009 binds to a protein called mesothelin, which is found on some cancer cells. Anti-mesothelin monoclonal antibody MORAb-009 may help the immune system kill cancer cells. It is a type of monoclonal antibody. Also called amatuximab and MORAb-009.

anti-PDGFR alpha monoclonal antibody IMC-3G3    listen   (AN-tee … AL-fuh MAH-noh-KLOH-nul AN-tee-BAH-dee …)
A substance being studied in the treatment of glioblastoma (a type of brain tumor) that has come back. It binds to receptors for a protein called platelet-derived growth factor (PDGF). This keeps PDGF from binding to the cells. This may stop the growth of cancer cells and blood vessels that have the receptors for PDGF. It is a type of monoclonal antibody. Also called anti-platelet-derived growth factor receptor alpha monoclonal antibody IMC-3G3 and IMC-3G3.

anti-platelet-derived growth factor receptor alpha monoclonal antibody IMC-3G3    listen   (AN-tee-PLAYT-let-deh-RIVED grothe FAK-ter reh-SEP-ter AL-fuh MAH-noh-KLOH-nul AN-tee-BAH-dee …)
A substance being studied in the treatment of glioblastoma (a type of brain tumor) that has come back. It binds to receptors for a protein called platelet-derived growth factor (PDGF). This keeps PDGF from binding to the cells. This may stop the growth of cancer cells and blood vessels that have the receptors for PDGF. It is a type of monoclonal antibody. Also called anti-PDGFR alpha monoclonal antibody IMC-3G3 and IMC-3G3.

anti-TGF-beta monoclonal antibody GC1008    listen   (AN-tee ... BAY-tuh MAH-noh-KLOH-nul AN-tee-BAH-dee ...)
A substance being studied in the treatment of breast cancer that has spread to other parts of the body. It is also being studied in the treatment of other cancers and conditions. Anti-TGF-beta monoclonal antibody GC1008 binds to a protein called transforming growth factor-beta (TGF-beta), which is found on some cancer cells. Anti-TGF-beta monoclonal antibody GC1008 may help keep cancer cells from growing and prevent the growth of new blood vessels that tumors need to grow. It is a type of monoclonal antibody and a type of antiangiogenesis agent. Also called fresolimumab and GC1008.

anti-TRAIL R1-mAb    listen   (AN-tee ...)
A substance being studied in the treatment of some types of cancer. It binds to a protein called TRAIL R1 on the surface of some tumor cells. This may kill the tumor cells. Anti-TRAIL R1-mAb is a type of monoclonal antibody. Also called HGS-ETR1 and mapatumumab.

anti-TRAIL R2 mAb HGS-ETR2    listen   (AN-tee ...)
A substance being studied in the treatment of some types of cancer. It binds to a protein called TRAIL-R2 on the surface of some tumor cells, which may kill the tumor cells. Anti-TRAIL R2 mAb HGS-ETR2 is a type of monoclonal antibody. Also called HGS-ETR2 and lexatumumab.

anti-VEGFR monoclonal antibody    listen   (AN-tee … MAH-noh-KLOH-nul AN-tee-BAH-dee)
A monoclonal antibody being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-VEGFR monoclonal antibodies bind to receptors for vascular endothelial growth factor (VEGF) and keeps VEGF from binding to them. This may stop the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.

anti-VEGFR-2 fully human monoclonal antibody IMC-1121B    listen   (AN-tee … ful-ee HYOO-mun MAH-noh-KLOH-nul AN-tee-BAH-dee …)
A drug used to treat cancer of the stomach or gastroesophageal junction (area where the esophagus connects to the stomach) that is advanced or has spread to other parts of the body. It is used in patients whose cancer has gotten worse after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Anti-VEGFR-2 fully human monoclonal antibody IMC-1121B binds to receptors for a protein called vascular endothelial growth factor (VEGF), which may be found on some types of cancer cells. This may prevent the growth of new blood vessels that tumors need to grow. Anti-VEGFR-2 fully human monoclonal antibody IMC-1121B is a type of antiangiogenesis agent and a type of monoclonal antibody. Also called Cyramza, IMC-1121B, and ramucirumab.

antiandrogen    listen   (AN-tee-AN-droh-jen)
A substance that keeps androgens (male hormones) from binding to proteins called androgen receptors, which can be found in prostate cells and cells of some other tissues. Treatment with antiandrogens may stop prostate cancer cells from growing. Examples of antiandrogens used to treat prostate cancer are flutamide, bicalutamide, enzalutamide, and nilutamide.

antiandrogen therapy    listen   (AN-tee-AN-droh-jen THAYR-uh-pee)
Treatment with drugs used to block production or interfere with the action of male sex hormones.

antiangiogenesis    listen   (AN-tee-AN-jee-oh-JEH-neh-sis)
Prevention of the growth of new blood vessels.

antiangiogenesis agent    listen   (AN-tee-AN-jee-oh-JEH-neh-sis AY-jent)
A drug or substance that keeps new blood vessels from forming. In cancer treatment, antiangiogenesis agents may prevent the growth of new blood vessels that tumors need to grow. Also called angiogenesis inhibitor.

antiangiogenic    listen   (AN-tee-AN-jee-oh-JEH-nik)
Having to do with reducing the growth of new blood vessels.

antianxiety agent    listen   (AN-tee-ang-ZY-eh-tee AY-jent)
A drug used to treat symptoms of anxiety, such as feelings of fear, dread, uneasiness, and muscle tightness, that may occur as a reaction to stress. Most antianxiety agents block the action of certain chemicals in the nervous system. Also called anxiolytic and anxiolytic agent.

antiapoptotic    listen   (AN-tee-A-pop-TAH-tik)
Something that prevents apoptosis. Apoptosis is a type of cell death in which a series of molecular steps in a cell leads to its death.

antibacterial    listen   (AN-tee-bak-TEER-ee-ul)
A substance that kills bacteria or stops them from growing and causing disease.

antibiotic    listen   (AN-tee-by-AH-tik)
A drug used to treat infections caused by bacteria and other microorganisms.

antibody    listen   (AN-tee-BAH-dee)
A protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). Each antibody can bind to only one specific antigen. The purpose of this binding is to help destroy the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen. An antibody is a type of immunoglobulin.

antibody therapy    listen   (AN-tee-BAH-dee THAYR-uh-pee)
Treatment with an antibody, a substance that can directly kill specific tumor cells or stimulate the immune system to kill tumor cells.

antibody-dependent cell-mediated cytotoxicity    listen   (AN-tee-BAH-dee-deh-PEN-dent sel-MEE-dee-AY-ted SY-toh-tok-SIH-sih-tee)
A type of immune reaction in which a target cell or microbe is coated with antibodies and killed by certain types of white blood cells. The white blood cells bind to the antibodies and release substances that kill the target cells or microbes. Also called ADCC and antibody-dependent cellular cytotoxicity.

antibody-dependent cellular cytotoxicity    listen   (AN-tee-BAH-dee-deh-PEN-dent SEL-yoo-ler SY-toh-tok-SIH-sih-tee)
A type of immune reaction in which a target cell or microbe is coated with antibodies and killed by certain types of white blood cells. The white blood cells bind to the antibodies and release substances that kill the target cells or microbes. Also called ADCC and antibody-dependent cell-mediated cytotoxicity.

anticachexia    listen   (AN-tee-kuh-KEK-see-uh)
Describes a drug or effect that works against cachexia (loss of body weight and muscle mass).

anticancer antibiotic    listen   (AN-tee-KAN-ser AN-tee-by-AH-tik)
A type of anticancer drug that blocks cell growth by interfering with DNA, the genetic material in cells. Also called antineoplastic antibiotic and antitumor antibiotic.

anticancer therapy    listen   (AN-tee-KAN-ser THAYR-uh-pee)
Treatment to stop or prevent cancer.

anticarcinogenic    listen   (AN-tee-KAR-sih-noh-JEH-nik)
Having to do with preventing or delaying the development of cancer.

anticoagulant    listen   (AN-tee-koh-A-gyuh-lunt)
A substance that is used to prevent and treat blood clots in blood vessels and the heart. Also called blood thinner.

anticonvulsant    listen   (AN-tee-kun-VUL-sunt)
A drug or other substance used to prevent or stop seizures or convulsions. Also called antiepileptic.

antidepressant    listen   (AN-tee-dee-PREH-sunt)
A drug used to treat depression.

antidiarrheal    listen   (AN-tee-dy-uh-REE-ul)
A substance used to treat diarrhea (frequent and watery bowel movements).

antiemetic    listen   (AN-tee-eh-MEH-tik)
A drug that prevents or reduces nausea and vomiting.

antiepileptic    listen   (AN-tee-EH-pih-LEP-tik)
A drug or other substance used to prevent or stop seizures or convulsions. Also called anticonvulsant.

antiestrogen    listen   (AN-tee-ES-truh-jin)
A substance that keeps cells from making or using estrogen (a hormone that plays a role in female sex characteristics, the menstrual cycle, and pregnancy). Antiestrogens may stop some cancer cells from growing and are used to prevent and treat breast cancer. They are also being studied in the treatment of other types of cancer. An antiestrogen is a type of hormone antagonist. Also called estrogen blocker.

antifolate    listen   (AN-tee-FOH-layt)
A type of drug that stops cells from using folic acid to make DNA and may kill cancer cells. Certain antifolates are used to treat some types of cancer and inflammatory conditions, such as rheumatoid arthritis. Also called folate antagonist and folic acid antagonist.

antifungal    listen   (AN-tee-FUN-gul)
A drug that treats infections caused by fungi.

antigen    listen   (AN-tih-jen)
Any substance that causes the body to make an immune response against that substance. Antigens include toxins, chemicals, bacteria, viruses, or other substances that come from outside the body. Body tissues and cells, including cancer cells, also have antigens on them that can cause an immune response. These antigens can also be used as markers in laboratory tests to identify those tissues or cells.

antigen-presenting cell    listen   (AN-tih-jen-preh-ZEN-ting sel)
A type of immune cell that boosts immune responses by showing antigens on its surface to other cells of the immune system. An antigen-presenting cell is a type of phagocyte. Also called APC.

antigen-presenting cell vaccine    listen   (AN-tih-jen-preh-ZEN-ting sel vak-SEEN)
A vaccine made of antigens and antigen-presenting cells (APCs). APCs boost an immune response by presenting antigens on their surfaces to other cells of the immune system. Also called APC vaccine.

antiglobulin test    listen   (AN-tee-GLAH-byoo-lin ...)
A laboratory test to identify antibodies that can bind to the surface of red blood cells or platelets and destroy them. This test is used to diagnose certain blood disorders in which patients make antibodies to their own red blood cells or platelets. It is also used to determine blood type. Also called Coombs test.

antihistamine    listen   (AN-tee-HIS-tuh-meen)
A type of drug that blocks the action of histamines, which can cause fever, itching, sneezing, a runny nose, and watery eyes. Antihistamines are used to prevent fevers in patients receiving blood transfusions and to treat allergies, coughs, and colds.

antihormone therapy    listen   (AN-tee-HOR-mone THAYR-uh-pee)
Treatment with drugs, surgery, or radiation in order to block the production or action of a hormone. Antihormone therapy may be used in cancer treatment because certain hormones are able to stimulate the growth of some types of tumors.

antilymphocyte globulin    listen   (AN-tee-LIM-foh-site GLAH-byoo-lin)
Serum from blood that contains antibodies that bind to human T cells. Antilymphocyte globulin is given to a patient before a stem cell transplant to kill T cells and lower the risk of graft-versus-host disease (GVHD). It is also used to treat GVHD and after a kidney transplant to help keep the body from rejecting the kidney. Also called antithymocyte globulin.

antimetabolite    listen   (AN-tee-meh-TA-boh-lite)
A drug that is very similar to natural chemicals in a normal biochemical reaction in cells but different enough to interfere with the normal division and functions of cells.

antimicrobial    listen   (AN-tee-my-KROH-bee-ul)
A substance that kills microorganisms such as bacteria or mold, or stops them from growing and causing disease.

antimicrotubule agent    listen   (AN-tee-MY-kroh-TOO-byool AY-jent)
A type of drug that blocks cell growth by stopping mitosis (cell division). Antimicrotubule agents interfere with microtubules (cellular structures that help move chromosomes during mitosis). They are used to treat cancer.

antimitotic agent    listen   (AN-tee-my-TAH-tik AY-jent)
A type of drug that blocks cell growth by stopping mitosis (cell division). They are used to treat cancer. Also called mitotic inhibitor.

antineoplastic    listen   (AN-tee-NEE-oh-PLAS-tik)
Blocking the formation of neoplasms (growths that may become cancer).

antineoplastic antibiotic    listen   (AN-tee-NEE-oh-PLAS-tik AN-tee-by-AH-tik)
A type of anticancer drug that blocks cell growth by interfering with DNA, the genetic material in cells. Also called anticancer antibiotic and antitumor antibiotic.

antineoplaston    listen   (AN-tee-NEE-oh-PLAS-ton)
A substance isolated from normal human blood and urine that is being tested as a type of treatment for some tumors and AIDS.

antioncogene    listen   (AN-tee-ON-koh-jeen)
A type of gene that makes a protein called a tumor suppressor protein that helps control cell growth. Mutations (changes in DNA) in antioncogenes may lead to cancer. Also called tumor suppressor gene.

antioxidant    listen   (AN-tee-OK-sih-dent)
A substance that protects cells from the damage caused by free radicals (unstable molecules made by the process of oxidation during normal metabolism). Free radicals may play a part in cancer, heart disease, stroke, and other diseases of aging. Antioxidants include beta-carotene, lycopene, vitamins A, C, and E, and other natural and manufactured substances.

antiparasitic    listen   (AN-tee-PAYR-uh-SIH-tik)
A drug used to treat infections caused by bacteria and parasites. It is also used in the treatment of some cancers.

antiprogestin    listen   (AN-tee-proh-JES-tin)
A substance that prevents cells from making or using progesterone (a hormone that plays a role in the menstrual cycle and pregnancy). Antiprogestins may stop some cancer cells from growing and they are being studied in the treatment of breast cancer. An antiprogestin is a type of hormone antagonist.

antipsychotic    listen   (AN-tee-sy-KAH-tik)
A type of drug used to treat symptoms of psychosis. These include hallucinations (sights, sounds, smells, tastes, or touches that a person believes to be real but are not real), delusions (false beliefs), and dementia (loss of the ability to think, remember, learn, make decisions, and solve problems). Most antipsychotics block the action of certain chemicals in the nervous system. Also called antipsychotic agent and neuroleptic agent.

antipsychotic agent    listen   (AN-tee-sy-KAH-tik AY-jent)
A type of drug used to treat symptoms of psychosis. These include hallucinations (sights, sounds, smells, tastes, or touches that a person believes to be real but are not real), delusions (false beliefs), and dementia (loss of the ability to think, remember, learn, make decisions, and solve problems). Most antipsychotic agents block the action of certain chemicals in the nervous system. Also called antipsychotic and neuroleptic agent.

antiretroviral therapy    listen   (AN-tee-REH-troh-VY-rul THAYR-uh-pee)
Treatment with drugs that inhibit the ability of the human immunodeficiency virus (HIV) or other types of retroviruses to multiply in the body.

antisense agent    listen   (AN-tee-sents AY-jent)
Small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the ability of the RNA to make a protein or work in other ways. Antisense agents may be used to block the production of proteins needed for cell growth. They are being studied in the treatment of several types of cancer. Also called antisense oligonucleotide.

antisense c-fos    listen   (AN-tee-sents ...)
A substance that has been studied in the treatment of cancer and is being studied in the treatment of rheumatoid arthritis and certain skin conditions. It blocks the production of a protein called c-fos, which helps control cell growth. This may kill cancer cells that need c-fos to grow. It is a type of antisense oligonucleotide. Also called c-fos antisense oligonucleotide.

antisense DNA    listen   (AN-tee-sents …)
Small pieces of DNA that can bind to specific molecules of RNA and block the cell’s ability to use the RNA to make a protein or work in other ways. Antisense DNA may be used to block the production of proteins needed for cell growth. It is being studied in the treatment of many types of cancer.

antisense oligonucleotide    listen   (AN-tee-sents AH-lih-goh-NOO-klee-oh-tide)
Small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the ability of the RNA to make a protein or work in other ways. Antisense oligonucleotides may be used to block the production of proteins needed for cell growth. They are being studied in the treatment of several types of cancer. Also called antisense agent.

antisense oligonucleotide therapy    listen   (AN-tee-sents AH-lih-goh-NOO-klee-oh-tide THAYR-uh-pee)
Treatment with antisense oligonucleotides. These are small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the cell’s ability to use the RNA to make a protein or work in other ways. Antisense oligonucleotides are being studied in the treatment of many types of cancer. Also called antisense therapy.

antisense RNA    listen   (AN-tee-sents …)
Small pieces of RNA that can bind to specific molecules of RNA and block the cell’s ability to use the RNA to make a protein or work in other ways. Antisense RNA may be used to block the production of proteins needed for cell growth. It is being studied in the treatment of many types of cancer.

antisense therapy    listen   (AN-tee-sents THAYR-uh-pee)
Treatment with antisense oligonucleotides. These are small pieces of DNA or RNA that can bind to specific molecules of RNA. This blocks the cell’s ability to use the RNA to make a protein or work in other ways. Antisense oligonucleotides are being studied in the treatment of many types of cancer. Also called antisense oligonucleotide therapy.

antisocial    listen   (AN-tee-SOH-shul)
Describes behavior that ignores the rights of others and the practices and laws of society.

antithymocyte globulin    listen   (AN-tee-THY-moh-site GLAH-byoo-lin)
Serum from blood that contains antibodies that bind to human T cells. Antithymocyte globulin is given to a patient before a stem cell transplant to kill T cells and lower the risk of graft-versus-host disease (GVHD). It is also used to treat GVHD and after a kidney transplant to help keep the body from rejecting the kidney. Also called antilymphocyte globulin.

antituberculosis    listen   (AN-tee-too-BER-kyoo-LOH-sis)
Describes a drug or effect that works against tuberculosis (a contagious bacterial infection that usually affects the lungs).

antitumor    listen   (AN-tee-TOO-mer)
Having to do with stopping abnormal cell growth.

antitumor antibiotic    listen   (AN-tee-TOO-mer AN-tee-by-AH-tik)
A type of anticancer drug that blocks cell growth by interfering with DNA, the genetic material in cells. Also called anticancer antibiotic and antineoplastic antibiotic.

antiviral    listen   (AN-tee-VY-rul)
A drug used to treat infections caused by viruses.

anus    listen   (AY-nus)
The opening of the rectum to the outside of the body.

anxiety    listen   (ang-ZY-eh-tee)
Feelings of fear, dread, and uneasiness that may occur as a reaction to stress. A person with anxiety may sweat, feel restless and tense, and have a rapid heart beat. Extreme anxiety that happens often over time may be a sign of an anxiety disorder.

anxiolysis    listen   (ANG-zee-AH-lih-sis)
A level of sedation in which a person is very relaxed and may be awake. The person is able to answer questions and follow instructions. Anxiolysis is caused by special drugs and is used to help relieve anxiety during certain medical or surgical procedures. Also called minimal sedation.

anxiolytic    listen   (ANG-zee-oh-LIH-tik)
A drug used to treat symptoms of anxiety, such as feelings of fear, dread, uneasiness, and muscle tightness, that may occur as a reaction to stress. Most anxiolytics block the action of certain chemicals in the nervous system. Also called antianxiety agent and anxiolytic agent.

anxiolytic agent    listen   (ANG-zee-oh-LIH-tik AY-jent)
A drug used to treat symptoms of anxiety, such as feelings of fear, dread, uneasiness, and muscle tightness, that may occur as a reaction to stress. Most anxiolytic agents block the action of certain chemicals in the nervous system. Also called antianxiety agent and anxiolytic.

Anzemet    listen   (AN-zeh-met)
A drug used to prevent nausea and vomiting caused by chemotherapy. It is also used to prevent nausea and vomiting after surgery. Anzemet blocks the action of the chemical serotonin, which binds to certain nerves and may trigger nausea and vomiting. Blocking serotonin may help lessen nausea and vomiting. It is a type of serotonin receptor antagonist and a type of antiemetic. Also called dolasetron mesylate.

aorta    listen   (ay-OR-tuh)
The largest artery in the body. It carries oxygen-rich blood away from the heart to vessels that reach the rest of the body.

aortocoronary bypass    listen   (ay-OR-toh-KOR-uh-NAYR-ee BY-pass)
Surgery in which a healthy blood vessel taken from another part of the body is used to make a new path for blood around a blocked artery leading to the heart. This restores the flow of oxygen and nutrients to the heart. Also called CAB and coronary artery bypass.

AP23573      
A substance being studied in the treatment of soft tissue and bone cancers. It is also being studied in the treatment of other solid tumors and hematologic cancer. AP23573 stops cells from dividing and may cause cancer cells to die. It is a type of mTOR inhibitor. Also called ridaforolimus.

AP5346      
A substance being studied in the treatment of head and neck cancer. It may kill cancer cells by carrying an anticancer drug into the tumor. It is a type of platinum compound.

APC      
A type of immune cell that boosts immune responses by showing antigens on its surface to other cells of the immune system. An APC is a type of phagocyte. Also called antigen-presenting cell.

APC vaccine    listen   (… vak-SEEN)
A vaccine made of antigens and antigen-presenting cells (APCs). APCs boost an immune response by presenting antigens on their surfaces to other cells of the immune system. Also called antigen-presenting cell vaccine.

APC8015      
A drug used to treat prostate cancer that has spread. It is made from immune system cells collected from a patient with prostate cancer. The cells are treated with a protein that is made by combining a protein found on prostate cancer cells with a growth factor. When the cells are injected back into the patient, they may stimulate T cells to kill prostate cancer cells. APC8015 is a type of vaccine and a type of cellular adoptive immunotherapy. Also called Provenge and sipuleucel-T.

APC8015F      
A vaccine made from immune system cells taken from a patient with prostate cancer and frozen for future use. The cells are treated in the laboratory with a growth factor attached to a protein called prostatic-acid phosphatase (PAP), which is found on prostate cancer cells. When APC8015F is injected into the patient, it may cause T cells (a type of white blood cell) to kill tumor cells that have PAP on them.

apheresis    listen   (a-feh-REE-sis)
A procedure in which blood is collected, part of the blood such as platelets or white blood cells is taken out, and the rest of the blood is returned to the donor. Also called pheresis.

Apidra    listen   (uh-PEE-druh)
A drug used to control the amount of sugar in the blood of patients with diabetes mellitus. It is a form of the hormone insulin that is made in the laboratory. Apidra gets into the blood faster than insulin when it is injected under the skin before or shortly after a meal. It is a type of therapeutic insulin. Also called insulin glulisine.

APL      
An aggressive (fast-growing) type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by an exchange of parts of chromosomes 15 and 17. Also called acute promyelocytic leukemia and promyelocytic leukemia.

aplastic anemia    listen   (AY-PLAS-tik uh-NEE-mee-uh)
A condition in which the bone marrow is unable to produce blood cells.

aplidine    listen   (AP-lih-deen)
A substance that is being studied in the treatment of cancer. It is obtained from a marine organism.

APN      
A registered nurse who has additional education and training in how to diagnose and treat disease. APNs are licensed at the state level and certified by national nursing organizations. In cancer care, an APN may manage the primary care of patients and their families, based on a practice agreement with a doctor. Also called advanced practice nurse, NP, and nurse practitioner.

Apo-2L    listen   (AY-poh …)
A cell protein that can attach to certain molecules in some cancer cells and may kill the cells. Apo-2L is being studied in the treatment of cancer. Also called TNF-related apoptosis-inducing ligand, TRAIL, and tumor necrosis factor-related apoptosis-inducing ligand.

apocrine gland    listen   (A-poh-krin ...)
A type of gland that is found in the skin, breast, eyelid, and ear. Apocrine glands in the breast secrete fat droplets into breast milk and those in the ear help form earwax. Apocrine glands in the skin and eyelid are sweat glands. Most apocrine glands in the skin are in the armpits, the groin, and the area around the nipples of the breast. Apocrine glands in the skin are scent glands, and their secretions usually have an odor. Another type of gland (eccrine gland or simple sweat gland) produces most sweat.

apolizumab    listen   (a-puh-LIZ-yoo-mab)
A substance being studied in the treatment of hematologic (blood) cancers. Apolizumab binds to a protein called ID10, which is found on the surface of some types of immune cells and cancer cells. It may help the immune system kill cancer cells. It is a type of monoclonal antibody.

apoptosis    listen   (A-pop-TOH-sis)
A type of cell death in which a series of molecular steps in a cell lead to its death. This is one method the body uses to get rid of unneeded or abnormal cells. The process of apoptosis may be blocked in cancer cells. Also called programmed cell death.

appendage    listen   (uh-PEN-dij)
In medicine, a body part (such as an arm or leg) that is attached to the main part of the body.

appendectomy    listen   (A-pen-DEK-toh-mee)
Surgery to remove the appendix (small finger-shaped pouch at the end of the first part of the large intestine).

appendix    listen   (uh-PEN-dix)
A small, fingerlike pouch that sticks out from the cecum (the first part of the large intestine near the end of the small intestine).

appetite    listen   (A-peh-tite)
A desire to satisfy a physical or mental need, such as for food, sex, or adventure.

aprepitant    listen   (uh-PREH-pih-tunt)
A drug used together with other drugs to prevent and control the nausea and vomiting caused by cancer treatment. It is also used to treat nausea and vomiting after surgery. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist. Also called Emend.

Aptivus    listen   (AP-tih-vus)
A drug used with another drug, ritonavir, to treat patients who are infected with HIV (the virus that causes AIDS) and have been treated with other anti-HIV drugs. Aptivus blocks the HIV virus from making copies of itself. It is a type of anti-HIV agent and a type of protease inhibitor. Also called tipranavir sodium.

aqueous    listen   (A-kwee-us)
Having to do with water.

AR      
A protein that binds male hormones called androgens. ARs are found inside the cells of male reproductive tissue, some other types of tissue, and some cancer cells. In prostate cancer, androgens bind to ARs inside the cancer cells, which causes the cancer cells to grow. Also called androgen receptor.

AR+    listen  
Describes cells that have a protein that binds to androgens (male hormones). Cancer cells that are AR+ may need androgens to grow. These cells may stop growing or die when they are treated with substances that block the binding and actions of androgen hormones. Also called androgen receptor positive.

arctigenin    listen   (ARK-tih-JEH-nin)
A substance found in certain plants, including burdock. It has shown antiviral and anticancer effects. Arctigenin belongs to a group of substances called lignans.

arctiin    listen   (ARK-tine)
A substance found in certain plants, including burdock. It has shown anticancer effects. Arctiin belongs to a group of substances called lignans.

Aredia    listen   (uh-REH-dee-uh)
A drug used to treat hypercalcemia (high blood levels of calcium) caused by certain types of cancer. It is also used with other anticancer drugs to treat multiple myeloma and breast cancer that has spread to bone. It is also used to treat Paget disease of the bone. Aredia may help keep bone from breaking down and prevent the loss of calcium from the bones. It is a type of bisphosphonate. Also called pamidronate disodium.

areola    listen   (ayr-EE-oh-luh)
The area of dark-colored skin on the breast that surrounds the nipple.

arginine    listen   (AR-jih-neen)
One of the twenty common amino acids (building blocks of proteins). Arginine is being studied as a nutritional supplement in the treatment and prevention of cancer and other conditions. Also called L-arginine.

arginine butyrate    listen   (AR-jih-neen BYOO-tuh-rayt)
A substance that is being studied in the treatment of cancer.

argon beam coagulator ablation    listen   (AR-gon beem coh-A-gyuh-LAY-ter a-BLAY-shun)
A procedure that destroys tissue with an electrical current passed through a stream of argon gas to the tissue. It is used to treat endometriosis and other conditions, and to stop blood loss during surgery.

Arixtra    listen   (uh-RIK-struh)
A drug used to prevent blood clots from forming inside blood vessels in the leg. It is being studied in the prevention of blood clots in some cancer patients, including women having surgery for cancer of the reproductive tract. It is a type of anticoagulant. Also called fondaparinux and fondaparinux sodium.

ARMD      
A condition in which there is a slow breakdown of cells in the center of the retina (the light-sensitive layers of nerve tissue at the back of the eye). This blocks vision in the center of the eye and can cause problems with activities such as reading and driving. ARMD is most often seen in people who are over the age of 50. Also called age-related macular degeneration, AMD, and macular degeneration.

armodafinil    listen   (ar-moh-DA-fih-nil)
A drug that is used to treat certain sleep disorders, such as narcolepsy. It makes patients feel more alert and awake. It is also being studied in the treatment of insomnia and fatigue in patients treated for cancer. Armodafinil acts in a part of the brain that controls sleep and wakefulness. It is a type of wakefulness-promoting agent. Also called Nuvigil.

ARMS      
A soft tissue tumor that is most common in older children and teenagers. It begins in embryonic muscle cells (cells that develop into muscles in the body). It can occur at many places in the body, but usually occurs in the trunk, arms, or legs. Also called alveolar rhabdomyosarcoma.

Aromasin    listen   (uh-ROH-muh-sin)
A drug used to treat advanced breast cancer and to prevent recurrent breast cancer in postmenopausal women who have already been treated with tamoxifen. It is also being studied in the treatment of other types of cancer. Aromasin causes a decrease in the amount of estrogen made by the body. It is a type of aromatase inhibitor. Also called exemestane.

aromatase inhibitor    listen   (uh-ROH-muh-tays in-HIH-bih-ter)
A drug that prevents the formation of estradiol, a female hormone, by interfering with an aromatase enzyme. Aromatase inhibitors are used as a type of hormone therapy for postmenopausal women who have hormone-dependent breast cancer.

aromatherapist    listen   (uh-ROH-muh-THAYR-uh-pist)
A person who practices a type of complementary medicine called aromatherapy. This therapy uses plant oils that give off strong, pleasant smells to promote relaxation and a sense of well-being. The plant oils are usually inhaled or put on the skin using wet cloths, baths, or massage.

aromatherapy    listen   (uh-ROH-muh-THAYR-uh-pee)
A type of complementary and alternative medicine that uses plant oils that give off strong pleasant aromas (smells) to promote relaxation, a sense of well-being, and healing.

aromatherapy infusion    listen   (uh-ROH-muh-THAYR-uh-pee in-FYOO-zhun)
The process of heating (without boiling) a mixture of water and an essential oil (scented liquid taken from a plant) to release a pleasant aroma. Aromatherapy infusion may also refer to the process of heating an herb in liquid to release the essential oils. Inhaled oxygen scented by aromatherapy infusion is being studied as a complementary therapy (used in addition to standard treatments) to relieve pain and shorten recovery time in patients undergoing colonoscopy.

aromatherapy massage    listen   (uh-ROH-muh-THAYR-uh-pee muh-SAZH)
A type of complementary and alternative medicine that uses rubbing and kneading of the skin with plant oils that give off strong, pleasant aromas (smells) to promote relaxation, a sense of well-being, and healing.

aromatic    listen   (AYR-oh-MA-tik)
Having an odor, which often is pleasant or spicy.

arousal    listen   (uh-ROW-zul)
The state of being alert and ready to respond, or waking from sleep.

Arranon    listen   (AYR-rah-non)
A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites. Also called 506U78 and nelarabine.

arrhenoblastoma    listen   (uh-REE-noh-blas-TOH-muh)
A rare type of ovarian tumor in which the tumor cells secrete a male sex hormone. This may cause virilization (the appearance of male physical characteristics in females). Also called androblastoma and Sertoli-Leydig cell tumor of the ovary.

arsenic    listen   (ARS-nik)
A poisonous chemical used to kill weeds and pests. Also used in cancer therapy.

arsenic trioxide    listen   (AR-seh-nik try-OK-side)
A drug used to treat acute promyelocytic leukemia (APL) that has not gotten better or that has come back after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Also called Trisenox.

art therapy    listen   (… THAYR-uh-pee)
Treatment that uses the making of art and the response to art to improve one’s physical, mental, and emotional well-being. Art therapy is sometimes used together with psychotherapy (talk therapy).

arterial embolization    listen   (ar-TEER-ee-ul EM-boh-lih-ZAY-shun)
A procedure in which the blood supply to a tumor or an abnormal area of tissue is blocked. During arterial embolization, a small incision (cut) is made in the inner thigh and a catheter (thin, flexible tube) is inserted and guided into an artery near the tumor or abnormal tissue. Once the catheter is in place, small particles made of tiny gelatin sponges or beads are injected. This blocks the artery and stops the flow of blood to the tumor or abnormal area of tissue. Arterial embolization is used to treat some types of liver cancer, kidney cancer, and neuroendocrine tumors. It may also be used to treat uterine fibroids, aneurysms, and other conditions. Also called TAE and transarterial embolization.

arteriogram    listen   (ar-TEER-ee-oh-gram)
An x-ray of arteries. The person receives an injection of a dye that outlines the vessels on the x-ray.

arteriography    listen   (ar-TEER-ee-AH-gruh-fee)
A procedure to x-ray arteries. The arteries can be seen because of an injection of a dye that outlines the vessels on the x-ray.

artery    listen   (AR-tuh-ree)
A blood vessel that carries blood from the heart to tissues and organs in the body.

arthralgia    listen   (ar-THRAL-juh)
Joint pain.

arthritis    listen   (ar-THRY-tis)
A disease that causes inflammation and pain in the joints.

artificial pacemaker    listen   (AR-tih-FIH-shul PAYS-may-ker)
An electronic device that is implanted in the body to monitor heart rate and rhythm. It gives the heart electrical stimulation when it does not beat normally. It runs on batteries and has long, thin wires that connect it to the heart. Also called cardiac pacemaker and pacemaker.

Arzerra    listen   (ar-ZAYR-uh)
A drug used to treat chronic lymphocytic leukemia (CLL) that has not gotten better with other anticancer drugs. It is also used with chlorambucil in patients who have not already been treated and cannot receive certain anticancer drugs. It is also being studied in the treatment of other types of cancer. Arzerra binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of leukemia and lymphoma cells. This may help the immune system kill cancer cells. Arzerra is a type of monoclonal antibody. Also called HuMax-CD20 and ofatumumab.

arzoxifene hydrochloride    listen   (ar-ZOK-sih-feen HY-droh-KLOR-ide)
A substance being studied in the treatment of osteoporosis and breast cancer. Arzoxifene hydrochloride is made in the laboratory and binds to estrogen receptors in the body. It is a type of selective estrogen receptor modulator (SERM). Also called LY353381 hydrochloride.

asbestos    listen   (as-BES-tus)
A group of minerals that take the form of tiny fibers. Asbestos has been used as insulation against heat and fire in buildings. Loose asbestos fibers breathed into the lungs can cause several serious diseases, including lung cancer and malignant mesothelioma (cancer found in the lining of the lungs, chest, or abdomen). Asbestos that is swallowed may cause cancer of the gastrointestinal tract.

asbestosis    listen   (as-bes-TOH-sis)
A lung disease caused by breathing in particles of asbestos (a group of minerals that take the form of tiny fibers). Symptoms include coughing, trouble breathing, and chest pain caused by scarring and permanent damage to lung tissue. Asbestosis increases the risk of lung cancer and malignant mesothelioma (cancer found in the lining of the lungs, chest, or abdomen).

ASC-H      
A finding of abnormal cells in a Pap test. It means there are abnormal squamous cells in the tissue that lines the outer part of the cervix. ASC-H may be a sign of a high-grade squamous intraepithelial lesion (HSIL), which may become cervical cancer if untreated. More testing may be needed. Also called atypical squamous cells, cannot exclude a high-grade lesion.

ascites    listen   (uh-SY-teez)
Abnormal buildup of fluid in the abdomen that may cause swelling. In late-stage cancer, tumor cells may be found in the fluid in the abdomen. Ascites also occurs in patients with liver disease.

ascorbic acid    listen   (uh-SKOR-bik A-sid)
A nutrient that the body needs in small amounts to function and stay healthy. Ascorbic acid helps fight infections, heal wounds, and keep tissues healthy. It is an antioxidant that helps prevent cell damage caused by free radicals (highly reactive chemicals). Ascorbic acid is found in all fruits and vegetables, especially citrus fruits, strawberries, cantaloupe, green peppers, tomatoes, broccoli, leafy greens, and potatoes. It is water-soluble (can dissolve in water) and must be taken in every day. Ascorbic acid is being studied in the prevention and treatment of some types of cancer. Also called vitamin C.

ASCUS    listen  
A finding of abnormal cells in the tissue that lines the outer part of the cervix. ASCUS is the most common abnormal finding in a Pap test. It may be a sign of infection with certain types of human papillomavirus (HPV). It may also be a sign of a benign (not cancer) growth, such as a cyst or polyp or, in menopausal women, of low hormone levels. More testing, such as an HPV test, may be needed. Also called atypical squamous cells of undetermined significance.

aseptic necrosis    listen   (ay-SEP-tik neh-KROH-sis)
A condition in which there is a loss of blood flow to bone tissue, which causes the bone to die. It is most common in the hips, knees, shoulders, and ankles. It may be caused by long-term use of steroid medicines, alcohol abuse, joint injuries, and certain diseases, such as cancer and arthritis. It may also occur at some point in time after cancer treatment that included methotrexate, bisphosphonates, or corticosteroids. Also called avascular necrosis, ischemic necrosis, and osteonecrosis.

Ashkenazi Jews    listen   (ASH-keh-NAH-zee jooz)
One of two major ancestral groups of Jewish individuals. The ancestors of Ashkenazi Jews lived in Central and Eastern Europe (e.g., Germany, Poland, Russia). The other group is called Sephardic Jews and includes those whose ancestors lived in North Africa, the Middle East, and Spain. Most Jews living in the United States are of Ashkenazi descent.

asparaginase    listen   (as-PAYR-uh-jih-NAYS)
A drug that is used to treat acute lymphoblastic leukemia (ALL) and is being studied in the treatment of some other types of cancer. It is an enzyme taken from the bacterium Escherichia coli (E. coli). It breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow. Also called Elspar and L-asparaginase.

asparaginase Erwinia chrysanthemi    listen   (as-PAYR-uh-jih-NAYS er-WIH-nee-uh krih-SAN-theh-my)
A drug used with other anticancer drugs to treat acute lymphoblastic leukemia (ALL). It is an enzyme that comes from the Erwinia chrysanthemi bacterium. It is used in patients who cannot take a similar drug that comes from the E. coli bacterium. It is also being studied in the treatment of other types of cancer. It breaks down the amino acid asparagine and may block the growth of cancer cells that need asparagine to grow. It may also kill cancer cells. Also called Erwinaze.

aspartate transaminase    listen   (as-PAR-tayt tranz-A-mih-nays)
An enzyme found in the liver, heart, and other tissues. A high level of aspartate transaminase released into the blood may be a sign of liver or heart damage, cancer, or other diseases. Also called serum glutamic-oxaloacetic transaminase and SGOT.

aspergillosis    listen   (AS-per-jih-LOH-sis)
An infectious fungal disease that occurs most often in the skin, ears, nasal sinuses, and lungs of people with suppressed immune systems.

Aspergillus    listen   (AS-per-JIH-lus)
Fungi commonly found in soil. Certain types of Aspergillus may cause disease, especially in people who have suppressed immune systems.

aspirate      
Aspirate (pronounced AS-pih-rit) refers to fluid, tissue, or other substance that is withdrawn from a body cavity, cyst, or tumor. Aspirate (pronounced AS-pih-rayt) refers to the act of withdrawing the fluid, tissue, or other substance through a needle. It also refers to the accidental breathing in of food or fluid into the lungs. This can cause serious problems, such as pneumonia and other lung problems.

aspiration    listen   (AS-pih-RAY-shun)
Removal of fluid or tissue through a needle. Also, the accidental breathing in of food or fluid into the lungs.

aspirin    listen   (AS-pih-rin)
A drug that reduces pain, fever, inflammation, and blood clotting. Aspirin belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is also being studied in cancer prevention.

ASPS      
A soft tissue tumor that is most common in older children and teenagers. It begins in the soft supporting tissue that connects and surrounds the organs and other tissues. ASPS usually occurs in the legs, but can also occur in the arms, hands, head, or neck. It can cause the growth of new blood vessels that help the tumor grow and spread. Also called alveolar soft part sarcoma.

assay    listen   (A-say)
A laboratory test to find and measure the amount of a specific substance.

assent process    listen   (uh-SENT PRAH-ses)
A process that is required by law in which children or adolescents are given easy-to-understand information about a clinical trial to help them decide if they want to take part in the trial. The patient is given a chance to ask questions about what will happen during the trial, why it’s being done, and what they will be asked to do. Formal consent to enter the trial comes from the parent or guardian.

assessment    listen   (uh-SES-ment)
In healthcare, a process used to learn about a patient’s condition. This may include a complete medical history, medical tests, a physical exam, a test of learning skills, tests to find out if the patient is able to carry out the tasks of daily living, a mental health evaluation, and a review of social support and community resources available to the patient.

assistive device    listen   (uh-SIS-tiv dee-VISE)
A tool that helps a person with a disability to do a certain task. Examples are a cane, wheelchair, scooter, walker, hearing aid, or special bed.

assistive technology    listen   (uh-SIS-tiv tek-NAH-loh-jee)
Any device or technology that helps a disabled person. Examples are special grips for holding utensils, computer screen monitors to help a person with low vision read more easily, computers controlled by talking, telephones that make the sound louder, and lifters to help a person rise out of a chair.

asthenia    listen   (as-THEE-nee-uh)
Weakness; lack of energy and strength.

asthma    listen   (AZ-muh)
A chronic disease in which the bronchial airways in the lungs become narrowed and swollen, making it difficult to breathe. Symptoms include wheezing, coughing, tightness in the chest, shortness of breath, and rapid breathing. An asthma attack may be brought on by pet hair, dust, smoke, pollen, mold, exercise, cold air, or stress.

astrocyte    listen   (AS-troh-site)
A large, star-shaped cell that holds nerve cells in place and helps them develop and work the way they should. An astrocyte is a type of glial cell.

astrocytoma    listen   (AS-troh-sy-TOH-muh)
A tumor that begins in the brain or spinal cord in small, star-shaped cells called astrocytes.

asymmetry    listen   (ay-SIH-meh-tree)
Lack or absence of balanced proportions between parts of a thing.

asymptomatic    listen   (AY-sim-toh-MA-tik)
Having no signs or symptoms of disease.

asymptomatic inflammatory prostatitis    listen   (AY-sim-toh-MA-tik in-FLA-muh-TOR-ee PROS-tuh-TY-tis)
Inflammation of the prostate gland where the only symptom is the presence of white blood cells in the prostate fluid.

AT/RT      
An aggressive cancer of the central nervous system, kidney, or liver that occurs in very young children. Also called ATT/RHT and atypical teratoid/rhabdoid tumor.

AT7519M      
A substance being studied in the treatment of some types of cancer. AT7519M blocks enzymes needed for cells to divide. It is a type of cyclin-dependent kinase inhibitor. Also called CDK inhibitor AT7519M.

AT9283      
A substance being studied in the treatment of some types of cancer. It blocks enzymes (Aurora kinases) involved in cell division and may kill cancer cells. AT9283 is a type of serine/threonine protein kinase inhibitor. Also called Aurora kinase inhibitor AT9283.

atamestane    listen   (uh-TA-meh-stayn)
A substance that is being studied in the treatment of cancer. Atamestane blocks the production of the hormone estrogen in the body. It belongs to the family of drugs called antiestrogens.

ataxia    listen   (uh-TAK-see-uh)
Loss of muscle coordination.

ataxia-telangiectasia    listen   (uh-TAK-see-uh-teh-LAN-jee-ek-TAY-zhuh)
A rare, inherited, progressive, degenerative disease of childhood that causes loss of muscle control, a weakened immune system, and an increased risk of cancer.

ataxic gait    listen   (uh-TAK-sik gayt)
Awkward, uncoordinated walking.

atelectasis    listen   (A-teh-LEK-tuh-sis)
Failure of the lung to expand (inflate) completely. This may be caused by a blocked airway, a tumor, general anesthesia, pneumonia or other lung infections, lung disease, or long-term bedrest with shallow breathing. Sometimes called a collapsed lung.

athymic nude mouse    listen   (ay-THY-mik nood ...)
A type of laboratory mouse that is hairless, lacks a normal thymus gland, and has a defective immune system because of a genetic mutation. Athymic nude mice are often used in cancer research because they do not reject tumor cells, from mice or other species.

atiprimod    listen   (uh-TIH-prih-mod)
A substance being studied in the treatment of certain multiple myelomas and other advanced cancers. Atiprimod may block the growth of tumors and may prevent the growth of new blood vessels that tumors need to grow. Atiprimod is a type of signal transduction inhibitor and a type of antiangiogenesis agent. Also called azaspirane and SK&F106615.

ATLL      
An aggressive (fast-growing) type of T-cell non-Hodgkin lymphoma caused by the human T-cell leukemia virus type 1 (HTLV-1). It is marked by bone and skin lesions, high calcium levels, and enlarged lymph nodes, spleen, and liver. Also called adult T-cell leukemia/lymphoma.

ATN-161      
A substance being studied in the treatment of some types of cancer. ATN-161 may prevent the spread of tumor cells and may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.

ATN-224      
A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. ATN-224 also blocks enzymes that cells need to divide and grow, and it may kill cancer cells. It is a type of antiangiogenesis agent and a type of superoxide dismutase inhibitor. Also called SOD1 inhibitor ATN-224.

atom    listen   (A-tum)
The smallest part of a substance that cannot be broken down chemically. Each atom has a nucleus (center) made up of protons (positive particles) and neutrons (particles with no charge). Electrons (negative particles) move around the nucleus. Atoms of different elements contain different numbers of protons, neutrons, and electrons.

atorvastatin    listen   (uh-TOR-vuh-STA-tin)
The active ingredient in a drug used to lower the amount of cholesterol in the blood and to prevent stroke, heart attack, and angina (chest pain). It is also being studied in the prevention and treatment of some types of cancer and other conditions. Atorvastatin blocks an enzyme that helps make cholesterol in the body. It also causes an increase in the breakdown of cholesterol. It is a type of HMG-CoA reductase inhibitor and a type of statin.

atorvastatin calcium    listen   (uh-TOR-vuh-STA-tin KAL-see-um)
A drug used to lower the amount of cholesterol in the blood and to prevent stroke, heart attack, and angina (chest pain). It is also being studied in the prevention and treatment of some types of cancer and other conditions. Atorvastatin calcium blocks an enzyme that helps make cholesterol in the body. It also causes an increase in the breakdown of cholesterol. It is a type of HMG-CoA reductase inhibitor and a type of statin. Also called Lipitor.

ATP      
A substance present in all living cells that provides energy for many metabolic processes and is involved in making RNA. ATP made in the laboratory is being studied in patients with advanced solid tumors to see if it can decrease weight loss and improve muscle strength. Also called adenosine triphosphate.

ATRA    listen  
A nutrient that the body needs in small amounts to function and stay healthy. ATRA is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of ATRA made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). ATRA is being studied in the prevention and treatment of other types of cancer. Also called all-trans retinoic acid, retinoic acid, tretinoin, and vitamin A acid.

atrasentan    listen   (A-truh-SEN-tan)
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called endothelin-1 protein receptor antagonists.

atropine sulfate    listen   (A-troh-peen SUL-fayt)
A drug used to block nerve stimulation of muscles and glands and relax smooth muscles. It is also used to increase heart rate, reduce secretions, and treat the effects of certain poisons. It is a type of antimuscarinic agent and a type of tropane alkaloid.

atropine suppression test    listen   (A-troh-peen suh-PREH-shun …)
A test used to help find out if secretion of pancreatic polypeptide (a protein released by the pancreas) is normal or caused by a tumor. A drug called atropine sulfate is injected into the patient’s vein and level of pancreatic polypeptide in the blood is measured. If there is a tumor, the injection will not change the level of pancreatic polypeptide. If there is no tumor, the level of pancreatic polypeptide will drop.

ATT/RHT      
An aggressive cancer of the central nervous system, kidney, or liver that occurs in very young children. Also called AT/RT and atypical teratoid/rhabdoid tumor.

attenuated    listen   (uh-TEN-yoo-way-ted)
Weakened or thinned. Attenuated strains of disease-causing bacteria and viruses are often used as vaccines. The weakened strains are used as vaccines because they stimulate a protective immune response while causing no disease or only mild disease in the person receiving the vaccine.

atypia    listen   (ay-TIH-pee-uh)
State of being not typical or normal. In medicine, atypia is an abnormality in cells in tissue.

atypical ductal breast hyperplasia    listen   (AY-TIH-pih-kul DUK-tul brest HY-per-PLAY-zhuh)
A benign (not cancer) condition in which there are more cells than normal in the lining of breast ducts and the cells look abnormal under a microscope. Having atypical ductal breast hyperplasia increases the risk of breast cancer. Also called ADH and atypical ductal hyperplasia.

atypical ductal hyperplasia    listen   (AY-TIH-pih-kul DUK-tul HY-per-PLAY-zhuh)
A benign (not cancer) condition in which there are more cells than normal in the lining of breast ducts and the cells look abnormal under a microscope. Having atypical ductal hyperplasia increases the risk of breast cancer. Also called ADH and atypical ductal breast hyperplasia.

atypical glandular cells    listen   (AY-TIH-pih-kul GLAN-juh-ler sels)
A finding of abnormal cells in a Pap test. The glandular cells come from the inner part of the cervix or the lining of the uterus. This finding may be a sign of cancer or other serious condition, and more testing may be needed. Also called AGC.

atypical glandular cells of undetermined significance    listen   (AY-TIH-pih-kul GLAN-juh-ler sels … UN-deh-TER-mind sig-NIH-fih-kunts)
A term that has been used to describe abnormal cells that come from glands in the walls of the cervix (the lower, narrow end of the uterus). These abnormal cells are found in a small number of Pap smears (a procedure used to detect cervical cancer) and may be a sign of more serious lesions or cancer. The term used now is atypical glandular cells. Also called AGUS and atypical glandular cells of uncertain significance.

atypical glandular cells of uncertain significance    listen   (AY-TIH-pih-kul GLAN-juh-ler sels … UN-ser-tun sig-NIH-fih-kunts)
A term that has been used to describe abnormal cells that come from glands in the walls of the cervix (the lower, narrow end of the uterus). These abnormal cells are found in a small number of Pap smears (a procedure used to detect cervical cancer) and may be a sign of more serious lesions or cancer. The term used now is atypical glandular cells. Also called AGUS and atypical glandular cells of undetermined significance.

atypical hyperplasia    listen   (AY-TIH-pih-kul HY-per-PLAY-zhuh)
A benign (not cancer) condition in which cells look abnormal under a microscope and are increased in number.

atypical lobular breast hyperplasia    listen   (AY-TIH-pih-kul LAH-byoo-ler brest HY-per-PLAY-zhuh)
A benign (not cancer) condition in which there are more cells than normal in the breast lobules and the cells look abnormal under a microscope. Having atypical lobular breast hyperplasia increases the risk of breast cancer. Also called ALH and atypical lobular hyperplasia.

atypical lobular hyperplasia    listen   (AY-TIH-pih-kul LAH-byoo-ler HY-per-PLAY-zhuh)
A benign (not cancer) condition in which there are more cells than normal in the breast lobules and the cells look abnormal under a microscope. Having atypical lobular hyperplasia increases the risk of breast cancer. Also called ALH and atypical lobular breast hyperplasia.

atypical mole    listen   (ay-TIH-pih-kul mole)
A type of nevus (mole) that looks different from a common mole. An atypical mole is often larger with borders that are not easy to see. Its color is usually uneven and can range from pink to dark brown. Parts of the mole may be raised above the skin surface. An atypical mole may develop into malignant melanoma (a type of skin cancer). Also called dysplastic nevus.

atypical squamous cells of undetermined significance    listen   (AY-TIH-pih-kul SKWAY-mus sels … UN-deh-TER-mind sig-NIH-fih-kunts)
A finding of abnormal cells in the tissue that lines the outer part of the cervix. Atypical squamous cells of undetermined significance is the most common abnormal finding in a Pap test. It may be a sign of infection with certain types of human papillomavirus (HPV). It may also be a sign of a benign (not cancer) growth, such as a cyst or polyp or, in menopausal women, of low hormone levels. More testing, such as an HPV test, may be needed. Also called ASCUS.

atypical squamous cells, cannot exclude a high-grade lesion    listen   (AY-TIH-pih-kul SKWAY-mus sels, KA-not ek-SKLOOD … hy-grayd LEE-zhun)
A finding of abnormal cells in a Pap test. It means there are abnormal squamous cells in the tissue that lines the outer part of the cervix. Atypical squamous cells, cannot exclude a high-grade lesion may be a sign of a high-grade squamous intraepithelial lesion (HSIL), which may become cervical cancer if untreated. More testing may be needed. Also called ASC-H.

atypical teratoid/rhabdoid tumor    listen   (AY-TIH-pih-kul TAYR-uh-toyd/RAB-doyd TOO-mer)
An aggressive cancer of the central nervous system, kidney, or liver that occurs in very young children. Also called AT/RT and ATT/RHT.

auditory    listen   (AW-duh-TOR-ee)
Having to do with the ear and the sense of hearing.

auditory brain stem response test    listen   (AW-duh-TOR-ee brayn stem reh-SPONTS …)
A test used to detect some types of hearing loss, such as hearing loss caused by injury or tumors that affect nerves involved in hearing. Electrodes are placed on the head and certain tones or clicking sounds are made. The electrodes measure nerve signals in the brain when it reacts to the sounds. Also called ABR test, BAER test, and brain stem auditory evoked response test.

Augmentin    listen   (awg-MEN-tin)
A drug used to treat bacterial infections. Adding the chemical clavulanate potassium to the antibiotic amoxicillin increases the amount of time the antibiotic stays active in the body. Augmentin is a type of combination antibiotic. Also called amoxicillin-clavulanate potassium.

augmerosen    listen   (awg-MEH-roh-sen)
A substance being studied in the treatment of cancer. It may kill cancer cells by blocking the production of a protein that makes cancer cells live longer and by making them more sensitive to anticancer drugs. It is a type of antisense oligodeoxyribonucleotide. Also called bcl-2 antisense oligodeoxynucleotide G3139, Genasense, and oblimersen sodium.

auricular    listen   (aw-RIH-kyoo-ler)
Having to do with the ear.

Aurimmune    listen   (AW-rih-MYOON)
A substance being studied in the treatment of some types of cancer. Aurimmune is made in the laboratory by binding a cancer-killing protein called tumor necrosis factor (TNF) to the surface of very tiny particles of gold. These TNF-gold particles may kill cancer cells without harming healthy tissue. Also called colloidal gold-bound tumor necrosis factor and TNF-bound colloidal gold.

Aurora B/C kinase inhibitor GSK1070916A    listen   (uh-ROR-uh … KY-nays in-HIH-bih-ter …)
A substance being studied in the treatment of some types of cancer. It blocks certain enzymes (Aurora kinases) involved in cell division and may kill cancer cells. It is a type of serine/threonine protein kinase inhibitor. Also called GSK1070916A.

Aurora kinase inhibitor AT9283    listen   (uh-ROR-uh KY-nays in-HIH-bih-ter...)
A substance being studied in the treatment of some types of cancer. It blocks enzymes (Aurora kinases) involved in cell division and may kill cancer cells. Aurora kinase inhibitor AT9283 is a type of serine/threonine protein kinase inhibitor. Also called AT9283.

aurotherapy    listen   (AW-roh-THAYR-uh-pee)
A procedure that uses gold salts (a salt form of the metal element gold) to treat diseases, such as rheumatoid arthritis. The gold salts stop cells from releasing chemicals that can harm tissues. Also called chrysotherapy and gold therapy.

autoantibody    listen   (AW-toh-AN-tee-BAH-dee)
An antibody made against substances formed by a person’s own body. Autoantibodies can directly destroy cells that have the substances on them or can make it easier for other white blood cells to destroy them. Some autoimmune diseases are caused by autoantibodies.

autoclave    listen   (AW-toh-KLAYV)
A device that uses steam under high pressure to sterilize medical and laboratory supplies and equipment.

autoclave-resistant factor    listen   (AW-toh-klayv-reh-ZIH-stunt FAK-ter)
A substance found in soybeans that may slow down or stop the spread of cancer. This substance does not break down in an autoclave (a device that uses steam under high pressure to sterilize medical and laboratory supplies and equipment).

autoimmune disease    listen   (AW-toh-ih-MYOON dih-ZEEZ)
A condition in which the body recognizes its own tissues as foreign and directs an immune response against them.

autoimmune enteropathy    listen   (AW-toh-ih-MYOON en-teh-RAH-puh-thee)
A rare disease in which certain cells in the intestine are destroyed by a patient’s immune system. It causes severe, chronic, diarrhea and usually occurs in children.

autoimmune hemolytic anemia    listen   (AW-toh-ih-MYOON hee-moh-LIH-tik uh-NEE-mee-uh)
A condition in which the body’s immune system stops red blood cells from forming or causes them to clump together. Autoimmune hemolytic anemia can occur in patients who have chronic lymphocytic leukemia (CLL). Also called immune complex hemolytic anemia and immunohemolytic anemia.

autoimmune thyroiditis    listen   (AW-toh-ih-MYOON thy-roy-DY-tis)
An autoimmune condition of the thyroid gland (a gland located beneath the larynx). It is caused by the formation of antibodies that attack the thyroid gland and it usually causes hypothyroidism (too little thyroid hormone). Symptoms include fatigue, weight gain, constipation, dry skin, depression, and the inability to exercise. It is more common in females and can run in families. Also called Hashimoto disease and Hashimoto thyroiditis.

autologous    listen   (aw-TAH-luh-gus)
Taken from an individual's own tissues, cells, or DNA.

autologous bone marrow    listen   (aw-TAH-luh-gus bone MAYR-oh)
In transplantation, refers to a person's own bone marrow. Bone marrow is the soft, sponge-like tissue in the center of most large bones that produces white blood cells, red blood cells, and platelets.

autologous bone marrow transplantation    listen   (aw-TAH-luh-gus bone MAYR-oh tranz-plan-TAY-shun)
A procedure in which bone marrow is removed from a person, stored, and then given back to the person after intensive treatment.

autologous expanded mesenchymal stem cells OTI-010    listen   (aw-TAH-luh-gus … meh-ZEN-kih-mul …)
A product that is made of special stem cells taken from a patient’s bone marrow and grown in the laboratory. After a patient’s bone marrow is destroyed by treatment with whole body irradiation or chemotherapy, these cells are injected back into the patient to help rebuild bone marrow. Autologous expanded mesenchymal stem cells OTI-010 has been studied in the prevention of graft-versus-host disease during stem cell transplant in patients receiving treatment for cancer. Autologous expanded mesenchymal stem cells OTI-010 is used in cellular therapy. Also called Stromagen.

autologous lymphocyte    listen   (aw-TAH-luh-gus LIM-foh-site)
In transplantation, refers to a person’s own white blood cells. Lymphocytes have a number of roles in the immune system, including the production of antibodies and other substances that fight infections and other diseases.

autologous stem cell transplantation    listen   (aw-TAH-luh-gus ... tranz-plan-TAY-shun)
A procedure in which blood-forming stem cells (cells from which all blood cells develop) are removed, stored, and later given back to the same person.

autologous tumor cell    listen   (aw-TAH-luh-gus TOO-mer sel)
A cancer cell from an individual's own tumor.

autonomic nervous system    listen   (AW-toh-NAH-mik NER-vus SIS-tem)
The part of the nervous system that controls muscles of internal organs (such as the heart, blood vessels, lungs, stomach, and intestines) and glands (such as salivary glands and sweat glands). One part of the autonomic nervous system helps the body rest, relax, and digest food and another part helps a person fight or take flight in an emergency. Also called ANS and involuntary nervous system.

autophagy    listen   (aw-TAH-fuh-jee)
A normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

Avage    listen   (AY-vazh)
A drug used on the skin to treat several skin conditions. It is also being studied in the treatment of basal cell skin cancer and basal cell nevus syndrome. Avage is related to vitamin A and is made in the laboratory. It turns on a gene that may help stop the growth of skin cancer cells. Avage is a type of synthetic retinoid. Also called tazarotene and Tazorac.

Avandia    listen   (uh-VAN-dee-uh)
A drug that helps control the amount of glucose (sugar) in the blood and is being studied in the prevention and treatment of some types of cancer. Avandia stops cells from growing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of thiazolidinedione and a type of antiangiogenesis agent. Also called rosiglitazone maleate.

avascular necrosis    listen   (ay-VAS-kyoo-ler neh-KROH-sis)
A condition in which there is a loss of blood flow to bone tissue, which causes the bone to die. It is most common in the hips, knees, shoulders, and ankles. It may be caused by long-term use of steroid medicines, alcohol abuse, joint injuries, and certain diseases, such as cancer and arthritis. It may also occur at some point in time after cancer treatment that included methotrexate, bisphosphonates, or corticosteroids. Also called aseptic necrosis, ischemic necrosis, and osteonecrosis.

Avastin    listen   (uh-VAS-tin)
A drug used to treat glioblastoma (a type of brain cancer) and certain types of colorectal cancer, lung cancer, and kidney cancer. It is also being studied in the treatment of other types of cancer. Avastin binds to a protein called vascular endothelial growth factor (VEGF). This may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent and a type of monoclonal antibody. Also called bevacizumab.

Avelox    listen   (A-veh-lox)
A drug used to treat bacterial infections. It is a type of fluoroquinolone. Also called moxifloxacin and moxifloxacin hydrochloride.

Aventyl    listen   (A-ven-til)
A drug used to treat depression. It may also be used to treat panic or anxiety disorders and certain types of pain, and to help people quit smoking. Aventyl increases the levels of norepinephrine and other natural chemicals in the brain. This helps improve mood and may reduce a person’s craving for nicotine. It is a type of tricyclic antidepressant. Also called nortriptyline and Pamelor.

Avita    listen   (uh-VEE-tuh)
A topical preparation of tretinoin that is used to treat acne. Tretinoin is a form of vitamin A.

AVN944      
A substance being studied in the treatment of cancer. It blocks cells from making DNA and RNA and may kill cancer cells. It is a type of inosine monophosphate dehydrogenase (IMPDH) inhibitor.

Avodart    listen   (A-vuh-dart)
A drug used to treat symptoms of an enlarged prostate gland. It is being studied in the treatment of male hair loss and prostate cancer. Avodart blocks enzymes the body needs to make male sex hormones. It is a type of 5-alpha reductase inhibitor. Also called dutasteride and GG745.

avoidance    listen   (uh-VOY-dunts)
The act of staying away from people, places, and thoughts that may cause anxiety, pain, or unpleasant feelings. Some types of cancer-related avoidance include refusing to accept a cancer diagnosis or get treatment, and using alcohol or other drugs to forget about having cancer.

axilla    listen   (ak-SIH-luh)
The underarm or armpit.

axillary    listen   (AK-sih-LAYR-ee)
Pertaining to the armpit area, including the lymph nodes that are located there.

axillary dissection    listen   (AK-sih-LAYR-ee dy-SEK-shun)
Surgery to remove lymph nodes found in the armpit region. Also called axillary lymph node dissection.

axillary lymph node    listen   (AK-sih-LAYR-ee limf node)
A lymph node in the armpit region that drains lymph from the breast and nearby areas.

axillary lymph node dissection    listen   (AK-sih-LAYR-ee limf node dy-SEK-shun)
Surgery to remove lymph nodes found in the armpit region. Also called axillary dissection.

axitinib    listen   (AK-sih-TIH-nib)
A drug used to treat advanced renal cell carcinoma (the most common type of kidney cancer). It is used in patients who have not gotten better with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Axitinib blocks the action of proteins called growth factor receptors and may prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent. Also called Inlyta.

Ayurveda    listen   (i-yer-VAY-duh)
A medical system from India that has been used for thousands of years. The goal is to cleanse the body and to restore balance to the body, mind, and spirit. It uses diet, herbal medicines, exercise, meditation, breathing, physical therapy, and other methods. It is a type of Complementary and Alternative Medicine (CAM) therapy. Also called Ayurvedic medicine.

Ayurvedic medicine    listen   (I-yer-VAY-dik MEH-dih-sin)
A medical system from India that has been used for thousands of years. The goal is to cleanse the body and to restore balance to the body, mind, and spirit. It uses diet, herbal medicines, exercise, meditation, breathing, physical therapy, and other methods. It is a type of Complementary and Alternative Medicine (CAM) therapy. Also called Ayurveda.

azacitidine    listen   (ay-zuh-SY-tih-deen)
A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called antimetabolites. Also called Mylosar and Vidaza.

azaspirane    listen   (AY-zuh-SPEER-ayn)
A substance being studied in the treatment of certain multiple myelomas and other advanced cancers. Azaspirane may block the growth of tumors and may prevent the growth of new blood vessels that tumors need to grow. Azaspirane is a type of signal transduction inhibitor and a type of antiangiogenesis agent. Also called atiprimod and SK&F106615.

azathioprine sodium    listen   (AY-zuh-THY-oh-preen SOH-dee-um)
A drug used to keep a patient from rejecting a transplanted kidney. It is also used in the treatment of rheumatoid arthritis that does not get better with other types of treatment. Azathioprine sodium blocks the growth of white blood cells and the synthesis of DNA, RNA, and protein. It is a type of immunosuppressant.

AZD0530      
A substance being studied in the treatment of some types of cancer. AZD0530 blocks enzymes needed for cancer growth. It is a type of tyrosine kinase inhibitor.

AZD2171      
A substance being studied in the treatment of some types of cancer. AZD2171 may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of antiangiogenesis agent and a type of vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Also called cediranib maleate and Recentin.

AZD2281      
A substance being studied in the treatment of breast, ovarian, and prostate cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. AZD2281 may cause cancer cells to die. It is a type of targeted therapy agent and a type of poly (ADP-ribose) polymerase inhibitor. Also called olaparib and PARP inhibitor AZD2281.

AZD6244      
A substance being studied in the treatment of several types of cancer. AZD6244 blocks proteins needed for cell growth and may kill cancer cells. It is a type of protein kinase inhibitor. Also called MEK inhibitor AZD6244 and selumetinib.

azoxymethane    listen   (ay-ZOK-see-MEH-thayn)
A substance that is used in cancer research to cause colon tumors in laboratory animals. This is done to test new diets, drugs, and procedures for use in cancer prevention and treatment.

AZQ      
An anticancer drug that is able to cross the blood-brain barrier and kill cancer cells in the central nervous system. Also called diaziquone.

AZT      
A drug that inhibits the human immunodeficiency virus (HIV) that causes AIDS. Also called zidovudine.

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