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NCI Drug Dictionary

  

tretinoin 
A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:all-trans retinoic acid
all-trans vitamin A acid
beta-retinoic acid
retinoic acid
TRA
trans retinoic acid
trans vitamin A acid
tretinoinum
Vitamin A Acid
US brand names:Aberel
Aknoten
Avita
Renova
Retin-A
Retin-A MICRO
Vesanoid
Foreign brand names:Airol
Cordes Vas
Dermairol
Epi-Aberel
Eudyna
Retisol-A
Stieva-A
Stieva-A Forte
Vitinoin
Abbreviation:ATRA
Acronyms:ATRA
TRA
Code name:Ro 5488
Chemical structure:(All-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid