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NCI Drug Dictionary

  

amrubicin hydrochloride 
The hydrochloride salt of a third-generation synthetic 9-amino-anthracycline with antineoplastic activity. Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of DNA replication, and RNA and protein synthesis, followed by cell growth inhibition and cell death. This agent has demonstrated a higher level of anti-tumor activity than conventional anthracycline drugs without exhibiting any indication of the cumulative cardiac toxicity common to this class of compounds. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Amirubicin Hydrochloride
Foreign brand name:Calsed
Abbreviation:AMR
Chemical structures:(+)-(7S,9S)-9-acetyl-9-amino-7-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]- 6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
5,12-naphthacenedione, 9-acetyl-9-amino-7-[(2-deoxy-β-D-erythro- pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-, (7S,9S)-