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NCI Drug Dictionary

NCI Drug Dictionary

  

sodium dichloroacetate 
The sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion inhibits pyruvate dehydrogenase kinase, resulting in the inhibition of glycolysis and a decrease in lactate production. This agent may stimulate apoptosis in cancer cells by restoring normal mitochondrial-induced apoptotic signaling. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Abbreviation:DCA