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NCI Drug Dictionary

NCI Drug Dictionary

  

I 131 monoclonal antibody CC49 
A radioimmunoconjugate of the humanized monoclonal antibody CC49 labeled with iodine I 131. Iodine I 131 monoclonal antibody CC49 delivers beta and gamma radiation-emitting I 131 radionuclide specifically to tumor cells that express tumor-associated glycoprotein (TAG)-72, allowing localization of TAG-72-expressing tumor cells with radioimaging devices in diagnostic applications or resulting in specific TAG-72-expressing tumor cell radiocytotoxicity in therapeutic applications. Monoclonal antibody CC49 binds to TAG-72, a pancarcinoma antigen, with high affinity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:I131 MOAB CC49
iodine I 131 monoclonal antibody CC49
Abbreviation:131I-MOAB CC49