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NCI Drug Dictionary

NCI Drug Dictionary

  

lapatinib ditosylate  Patient Information
The ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Lapatinib
US brand name:Tykerb
Code names:GSK572016
GW2016
GW-572016