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NCI Drug Dictionary


A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Zyflo
Chemical structures:(+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea