NCI Drug Dictionary
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An immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||DM1-conjugated monoclonal antibody MLN591 |
maytansinoid -1 conjugated with MLN591 monoclonal antibody