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NCI Drug Dictionary

  

pertuzumab  Patient Information
A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:2C4
2C4 antibody
monoclonal antibody 2C4
rhuMAb2C4
rhuMAb-2C4
US brand name:Perjeta
Abbreviation:MOAB 2C4