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NCI Drug Dictionary

NCI Drug Dictionary

  

PEG-interferon alfa-2a 
A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2a protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2a, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:pegylated interferon alfa-2a
US brand name:PEGASYS
Abbreviation:PEG-IFNA2a