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NCI Drug Dictionary

  

valproic acid 
A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Valproate
Valproate Sodium
US brand name:Depakene
Foreign brand names:Alti-Valproic
Ergenyl
Novo-Valproic
Abbreviation:VA
Chemical structures:2-Propylpentanoic Acid
2-Propylvaleric Acid
Di-n-propylacetic Acid