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NCI Drug Dictionary

NCI Drug Dictionary

  

OSI-7904L 
A liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:OSI-7904 liposomal
Code name:GS7904L