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NCI Drug Dictionary

  

lutetium Lu 177 monoclonal antibody J591 
A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against the extracellular domain of prostate-specific membrane antigen linked to a beta-emitting radioisotope (lutetium-177). This radioimmunoconjugate binds to tumor cells that express the extracellular domain of prostate-specific membrane antigen, delivering beta particle radiation selectively to tumor cells expressing this antigen and so limiting the exposure of normal tissues to ionizing radiation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Abbreviation:Lu 177 MOAB J591