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NCI Drug Dictionary

NCI Drug Dictionary

  

urokinase-derived peptide A6 
An octapeptide (amino acids 136-143) derived from the proteolytic enzyme urokinase plasminogen activator (uPA), with potential antineoplastic activity. A6 is derived from the nonreceptor-binding domain and connecting region of urokinase. Administration of A6 inhibits the interaction of uPA with its receptor uPAR, and may inhibit endothelial cell motility and tumor cell invasion. uPA and uPAR promote extracellular matrix degradation and growth factor activation and correlate positively with angiogenesis, cancer cell invasion and metastasis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Abbreviation:A6