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NCI Drug Dictionary

NCI Drug Dictionary

  

cilengitide 
A cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Abbreviation:EMD 121974
Code name:EMD 121974
Chemical structure:cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl)