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NCI Drug Dictionary

  

donepezil hydrochloride 
The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Donepezil
US brand name:Aricept
Abbreviation:DONEP