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NCI Drug Dictionary


bismuth Bi213 monoclonal antibody M195 
A radioimmunoconjugate consisting of murine monoclonal antibody (M195) and bismuth 213 (Bi213). Monoclonal antibody M195 binds to CD33, a surface antigen expressed by myelogenous leukemia cells. Bi213 is an isotope that emits short-ranged high-energy alpha particles. This radioimmunoconjugate selectively delivers alpha particle-mediated cytotoxicity to leukemic cells, thereby limiting the exposure of normal tissues to ionizing radiation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Abbreviation:Bi213 MOAB M195