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NCI Drug Dictionary

NCI Drug Dictionary

  

valdecoxib 
A sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Bextra
Code name:SC 65872
Chemical structure:4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide