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NCI Drug Dictionary

NCI Drug Dictionary

  

liposomal paclitaxel 
A liposome-encapsulated formulation of paclitaxel, a taxoid compound extracted from the Pacific yew tree Taxus brevifolia, with antineoplastic property. Paclitaxel binds to tubulin and interferes with the assembly/disassembly dynamics of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis via inactivation of the apoptosis inhibitor, B-cell Leukemia 2 (Bcl-2) protein. Paclitaxel liposome formulation potentially enhances delivery of higher doses of paclitaxel to the target tissues and exhibits lower systemic toxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:LEP
liposome-encapsulated paclitaxel
paclitaxel liposome
US brand name:LEP-ETU
Abbreviation:PNU-93914