In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary

NCI Drug Dictionary

  

idronoxil 
A synthetic flavonoid derivative. Idronoxil activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:phenoxodiol
Code name:NV-06
Chemical structure:3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol